Objective To analyze the effect of ICD coding defects on disease grouping of Diagnosis-Intervention Packet(DIP)high-cost biased cases.Methods Data from the home page of medical record and the cost settlement of 342 DIP high-cost biased cases in a tertiary grade A general hospital from 2019 to 2021 were collected.The quali-ty control of ICD codes of DIP high-cost biased cases was performed.After the incorrect ICD codes were cor-rected,the cases were grouped again by DIP.The changes of disease grouping and score before and after the coding correction were analyzed by paired Wilcoxon signed-rank test.Results The defect rate of ICD coding with DIP high-cost biased cases was 19.30％,the defect rate of ICD coding for main diagnosis was 9.36％.The ratio of coding defects of tumor,respiratory system and cardiovascular disease accumulates to 57.53％.The defect rate of coding for operation was 7.93％.Among the 66 cases with ICD coding defects,35 cases with revised codes were regrouped,and the classification and score of DIP disease were changed.The DIP median score increased from 1 022 to 1 089,which was statistically significant(Z=-2.71,P=0.03).Conclusion The DIP high-cost biased cases had a high rate of ICD coding defects.The defect rate of ICD coding in the diagnosis of tumor,respiratory system and circulatory system was prominent.The hospital should make specific measures to improve the quality of ICD coding,provide the key support for the DIP disease grouping,and promote the hospital fine management and high-quality development.

Objective To analyze the effect of ICD coding defects on disease grouping of Diagnosis-Intervention Packet(DIP)high-cost biased cases.Methods Data from the home page of medical record and the cost settlement of 342 DIP high-cost biased cases in a tertiary grade A general hospital from 2019 to 2021 were collected.The quali-ty control of ICD codes of DIP high-cost biased cases was performed.After the incorrect ICD codes were cor-rected,the cases were grouped again by DIP.The changes of disease grouping and score before and after the coding correction were analyzed by paired Wilcoxon signed-rank test.Results The defect rate of ICD coding with DIP high-cost biased cases was 19.30％,the defect rate of ICD coding for main diagnosis was 9.36％.The ratio of coding defects of tumor,respiratory system and cardiovascular disease accumulates to 57.53％.The defect rate of coding for operation was 7.93％.Among the 66 cases with ICD coding defects,35 cases with revised codes were regrouped,and the classification and score of DIP disease were changed.The DIP median score increased from 1 022 to 1 089,which was statistically significant(Z=-2.71,P=0.03).Conclusion The DIP high-cost biased cases had a high rate of ICD coding defects.The defect rate of ICD coding in the diagnosis of tumor,respiratory system and circulatory system was prominent.The hospital should make specific measures to improve the quality of ICD coding,provide the key support for the DIP disease grouping,and promote the hospital fine management and high-quality development.

Objective To analyze the effect of ICD coding defects on disease grouping of Diagnosis-Intervention Packet(DIP)high-cost biased cases.Methods Data from the home page of medical record and the cost settlement of 342 DIP high-cost biased cases in a tertiary grade A general hospital from 2019 to 2021 were collected.The quali-ty control of ICD codes of DIP high-cost biased cases was performed.After the incorrect ICD codes were cor-rected,the cases were grouped again by DIP.The changes of disease grouping and score before and after the coding correction were analyzed by paired Wilcoxon signed-rank test.Results The defect rate of ICD coding with DIP high-cost biased cases was 19.30％,the defect rate of ICD coding for main diagnosis was 9.36％.The ratio of coding defects of tumor,respiratory system and cardiovascular disease accumulates to 57.53％.The defect rate of coding for operation was 7.93％.Among the 66 cases with ICD coding defects,35 cases with revised codes were regrouped,and the classification and score of DIP disease were changed.The DIP median score increased from 1 022 to 1 089,which was statistically significant(Z=-2.71,P=0.03).Conclusion The DIP high-cost biased cases had a high rate of ICD coding defects.The defect rate of ICD coding in the diagnosis of tumor,respiratory system and circulatory system was prominent.The hospital should make specific measures to improve the quality of ICD coding,provide the key support for the DIP disease grouping,and promote the hospital fine management and high-quality development.

Objective To analyze the effect of ICD coding defects on disease grouping of Diagnosis-Intervention Packet(DIP)high-cost biased cases.Methods Data from the home page of medical record and the cost settlement of 342 DIP high-cost biased cases in a tertiary grade A general hospital from 2019 to 2021 were collected.The quali-ty control of ICD codes of DIP high-cost biased cases was performed.After the incorrect ICD codes were cor-rected,the cases were grouped again by DIP.The changes of disease grouping and score before and after the coding correction were analyzed by paired Wilcoxon signed-rank test.Results The defect rate of ICD coding with DIP high-cost biased cases was 19.30％,the defect rate of ICD coding for main diagnosis was 9.36％.The ratio of coding defects of tumor,respiratory system and cardiovascular disease accumulates to 57.53％.The defect rate of coding for operation was 7.93％.Among the 66 cases with ICD coding defects,35 cases with revised codes were regrouped,and the classification and score of DIP disease were changed.The DIP median score increased from 1 022 to 1 089,which was statistically significant(Z=-2.71,P=0.03).Conclusion The DIP high-cost biased cases had a high rate of ICD coding defects.The defect rate of ICD coding in the diagnosis of tumor,respiratory system and circulatory system was prominent.The hospital should make specific measures to improve the quality of ICD coding,provide the key support for the DIP disease grouping,and promote the hospital fine management and high-quality development.

Objective To analyze the effect of ICD coding defects on disease grouping of Diagnosis-Intervention Packet(DIP)high-cost biased cases.Methods Data from the home page of medical record and the cost settlement of 342 DIP high-cost biased cases in a tertiary grade A general hospital from 2019 to 2021 were collected.The quali-ty control of ICD codes of DIP high-cost biased cases was performed.After the incorrect ICD codes were cor-rected,the cases were grouped again by DIP.The changes of disease grouping and score before and after the coding correction were analyzed by paired Wilcoxon signed-rank test.Results The defect rate of ICD coding with DIP high-cost biased cases was 19.30％,the defect rate of ICD coding for main diagnosis was 9.36％.The ratio of coding defects of tumor,respiratory system and cardiovascular disease accumulates to 57.53％.The defect rate of coding for operation was 7.93％.Among the 66 cases with ICD coding defects,35 cases with revised codes were regrouped,and the classification and score of DIP disease were changed.The DIP median score increased from 1 022 to 1 089,which was statistically significant(Z=-2.71,P=0.03).Conclusion The DIP high-cost biased cases had a high rate of ICD coding defects.The defect rate of ICD coding in the diagnosis of tumor,respiratory system and circulatory system was prominent.The hospital should make specific measures to improve the quality of ICD coding,provide the key support for the DIP disease grouping,and promote the hospital fine management and high-quality development.

Objective To analyze the effect of ICD coding defects on disease grouping of Diagnosis-Intervention Packet(DIP)high-cost biased cases.Methods Data from the home page of medical record and the cost settlement of 342 DIP high-cost biased cases in a tertiary grade A general hospital from 2019 to 2021 were collected.The quali-ty control of ICD codes of DIP high-cost biased cases was performed.After the incorrect ICD codes were cor-rected,the cases were grouped again by DIP.The changes of disease grouping and score before and after the coding correction were analyzed by paired Wilcoxon signed-rank test.Results The defect rate of ICD coding with DIP high-cost biased cases was 19.30％,the defect rate of ICD coding for main diagnosis was 9.36％.The ratio of coding defects of tumor,respiratory system and cardiovascular disease accumulates to 57.53％.The defect rate of coding for operation was 7.93％.Among the 66 cases with ICD coding defects,35 cases with revised codes were regrouped,and the classification and score of DIP disease were changed.The DIP median score increased from 1 022 to 1 089,which was statistically significant(Z=-2.71,P=0.03).Conclusion The DIP high-cost biased cases had a high rate of ICD coding defects.The defect rate of ICD coding in the diagnosis of tumor,respiratory system and circulatory system was prominent.The hospital should make specific measures to improve the quality of ICD coding,provide the key support for the DIP disease grouping,and promote the hospital fine management and high-quality development.

Objective To analyze the effect of ICD coding defects on disease grouping of Diagnosis-Intervention Packet(DIP)high-cost biased cases.Methods Data from the home page of medical record and the cost settlement of 342 DIP high-cost biased cases in a tertiary grade A general hospital from 2019 to 2021 were collected.The quali-ty control of ICD codes of DIP high-cost biased cases was performed.After the incorrect ICD codes were cor-rected,the cases were grouped again by DIP.The changes of disease grouping and score before and after the coding correction were analyzed by paired Wilcoxon signed-rank test.Results The defect rate of ICD coding with DIP high-cost biased cases was 19.30％,the defect rate of ICD coding for main diagnosis was 9.36％.The ratio of coding defects of tumor,respiratory system and cardiovascular disease accumulates to 57.53％.The defect rate of coding for operation was 7.93％.Among the 66 cases with ICD coding defects,35 cases with revised codes were regrouped,and the classification and score of DIP disease were changed.The DIP median score increased from 1 022 to 1 089,which was statistically significant(Z=-2.71,P=0.03).Conclusion The DIP high-cost biased cases had a high rate of ICD coding defects.The defect rate of ICD coding in the diagnosis of tumor,respiratory system and circulatory system was prominent.The hospital should make specific measures to improve the quality of ICD coding,provide the key support for the DIP disease grouping,and promote the hospital fine management and high-quality development.

Objective To analyze the effect of ICD coding defects on disease grouping of Diagnosis-Intervention Packet(DIP)high-cost biased cases.Methods Data from the home page of medical record and the cost settlement of 342 DIP high-cost biased cases in a tertiary grade A general hospital from 2019 to 2021 were collected.The quali-ty control of ICD codes of DIP high-cost biased cases was performed.After the incorrect ICD codes were cor-rected,the cases were grouped again by DIP.The changes of disease grouping and score before and after the coding correction were analyzed by paired Wilcoxon signed-rank test.Results The defect rate of ICD coding with DIP high-cost biased cases was 19.30％,the defect rate of ICD coding for main diagnosis was 9.36％.The ratio of coding defects of tumor,respiratory system and cardiovascular disease accumulates to 57.53％.The defect rate of coding for operation was 7.93％.Among the 66 cases with ICD coding defects,35 cases with revised codes were regrouped,and the classification and score of DIP disease were changed.The DIP median score increased from 1 022 to 1 089,which was statistically significant(Z=-2.71,P=0.03).Conclusion The DIP high-cost biased cases had a high rate of ICD coding defects.The defect rate of ICD coding in the diagnosis of tumor,respiratory system and circulatory system was prominent.The hospital should make specific measures to improve the quality of ICD coding,provide the key support for the DIP disease grouping,and promote the hospital fine management and high-quality development.

Objective: To investigate the association between the whole blood riboflavin level and the occurrence, development and prognosis of esophageal squamous cell carcinoma (ESCC) in China. Methods: From March 2014 to September 2018, ESCC patients from three hospitals (the Affiliated Hospital of Medical College of Shantou University, Shantou Central Hospital in Southern Chaoshan area and First Affiliated Hospital of Zhengzhou University in Northern Taihang Mountain) were selected as a case group; non-esophageal patients who had a physical examination were selected as a control group. The case and control group were paired by age (±5 years) and a 1:1 ration. A total of 1 528 subjects were enrolled including 764 patients in the case group and 764 patients in the control group. About 3-5 ml venous blood samples were collected, and the erythrocyte glutathione reductase activity coefficient (GRAC) was measured to assess the whole blood riboflavin level. A multivariate conditional logistic regression model was used to analyze the association between the GRAC and the risk of ESCC. The association between the GRAC and the prognosis of ESCC was analyzed by using Cox proportional risk regression model based on 288 patients with complete survival data. They were divided into two groups, the high GRAC group (GRAC≥7.87) group and the low GRAC group (GRAC<7.87) according to the strongest correlation between the total survival time, survival outcome and GRAC (GRAC=7.87). Results: Among the 1 528 patients, 958 patients were from Southern Chaoshan area, including 479 patients in the case group with an average age about (59.90±9.34) years and 479 patients in the control group with an average age about (59.55±8.77) years. Other 570 patients were from Northern Taihang Mountain area, including 285 patients in the case group with an average age (58.39±5.19) years and 285 patients in the control group with an average age about (58.74±4.57) years. The multivariate conditional logistic regression showed that the OR (95%CI) of the GRAC and the risk of ESCC was 1.009 (0.998-1.019). The Cox proportional hazard regression model analysis showed that the HR (95%CI) of the high GRAC group was 1.712 (1.034-2.824) compared with the low GRAC group in the 50-70 years group. Conclusion The whole blood riboflavin level might not be associated with the occurrence of ESCC. The high whole blood riboflavin level would be more beneficial to the prognosis of ESCC patients aged 50-70 years.

OBJECTIVE： To observe the improvement effects of water extract of Glycyrrhiza uralensis on acute hepatic injury caused by triptolide and its effects on the levels of IL-10 and TNF-α in rats. METHODS： A total of 60 healthy male SD rats were randomized into blank control group， model group， positive control group （magnesium isoglycyrrhizinate） and G. uralensis water extract low-dose， middle-dose and high-dose groups. Blank control group and model group were given isochoric normal saline intragastrically； positive control group was given Magnesium isoglycyrrhizinate liquid intragastrically （13.5 mg/kg）； G. uralensis water extract low-dose， middle-dose and high-dose groups were given G. uralensis water extract intragastrically 1 mL （120， 240， 480 mg/kg， by the amount of extract）， qd， for consecutive 7 d. At 8th day of administration， model group， positive control group and G. uralensis water extract groups were given Triptolide liquid intragastrically （0.6 mg/kg） to establish acute liver injury model. HE staining was used to detect the pathological changes of liver tissue in rats. The activities of ALT and AST in serum were determined by enzyme coupling reaction. The protein expression of IL-10 and TNF-α in liver tissue were analyzed by Western blotting. RESULTS： Compared with blank control group， obvious pathological changes of liver tissue in rats were observed in model group； serum activities of ALT and AST， the protein expression level of TNF-α in liver tissue were increased significantly， while the protein expression level of IL-10 was decreased significantly （P＜0.01）. Compared with model group， pathological changes of liver tissue were relieved significantly. Except for the activity of AST in serum of rats in G. uralensis water extract low-dose group， the activities of ALT and AST in serum， the protein expression level of TNF-α in liver tissue were decreased significantly in G. uralensis groups， while the protein expression level of IL-10 in liver tissue was increased significantly （P＜0.05 or P＜0.01）. CONCLUSIONS： G. uralensis water extract can relieve triptolide-induced acute liver injury in rats， the mechanism of which may be associated with expression down-regulation of pro-inflammatory factor TNF-α and expression up-regulation of anti-inflammatory factor IL-10.