Objective:This study aims to explore how urban medical groups can empower the scientific research development of primary hospitals through collaborative efforts, providing experience reference for the research construction of medical consortiums.Methods:Taking the Shenzhen Dapeng New District Medical and Health Group as an example, the study examined the impact of the group′s establishment on the research capabilities of primary hospitals in terms of research spirit, team and facilities. It summarized the group′s efforts to promote primary hospital research outcomes through various measures, including establishing funds, building mechanisms, setting up platforms and implementing stratified training.Results:The number of research projects approved by the group had significantly increased, with participation in national key research and development projects as sub-centers for cohort studies. The publication volume of SCI papers had continuously climbed. The integration of research and clinical practice had promoted the introduction of new technologies, significantly enhancing diagnostic and treatment capabilities and public satisfaction.Conclusions:Urban medical groups can address challenges such as the scarcity of research resources in primary hospitals through collaborative mechanisms, offering a replicable pathway for research capacity improvement. However, there is still room for improvement, including deepening the cultivation of scientific research talents and improving the support system to promote the sustainable development of primary hospital research.

Objective:This study aims to explore how urban medical groups can empower the scientific research development of primary hospitals through collaborative efforts, providing experience reference for the research construction of medical consortiums.Methods:Taking the Shenzhen Dapeng New District Medical and Health Group as an example, the study examined the impact of the group′s establishment on the research capabilities of primary hospitals in terms of research spirit, team and facilities. It summarized the group′s efforts to promote primary hospital research outcomes through various measures, including establishing funds, building mechanisms, setting up platforms and implementing stratified training.Results:The number of research projects approved by the group had significantly increased, with participation in national key research and development projects as sub-centers for cohort studies. The publication volume of SCI papers had continuously climbed. The integration of research and clinical practice had promoted the introduction of new technologies, significantly enhancing diagnostic and treatment capabilities and public satisfaction.Conclusions:Urban medical groups can address challenges such as the scarcity of research resources in primary hospitals through collaborative mechanisms, offering a replicable pathway for research capacity improvement. However, there is still room for improvement, including deepening the cultivation of scientific research talents and improving the support system to promote the sustainable development of primary hospital research.

In recent years , there are increasing articles concerning Epstein-Barr virus associated lymphoproliferative disorder (EBV+LPD), and the name of EBV +LPD is used widely.However,the meaning of EBV+LPD used is not the same , which triggered confusion of the understanding and obstacles of the communication.In order to solve this problem.Literature was reviewed with combination of our cases to clarify the concept of EBV +LPD and to expound our understanding about it .In general, it is currently accepted that EBV +LPD refers to a spectrum of lymphoid tissue diseases with EBV infection , including hyperplasia , borderline lesions , and neoplastic diseases .According to this concept , EBV+LPD should not include infectious mononucleosis ( IM ) and severe acute EBV infection ( EBV +hemophagocytic lymphohistiocytosis, fatal IM, fulminant IM, fulminant T-cell LPD), and should not include the explicitly named EBV+lymphomas ( such as extranodal NK/T cell lymphoma , aggressive NK cell leukemia , Burkitt lymphoma, and Hodgkin lymphoma , etc.) either.EBV +LPD should currently include: ( 1 ) EBV +B cell-LPD:lymphomatoid granulomatosis , EBV +immunodeficiency related LPD , chronic active EBV infection-B cell type, senile EBV +LPD, etc.(2) EBV +T/NK cell-LPD:CAEBV-T/NK cell type, hydroa vacciniforme, hypersensitivity of mosquito bite, etc.In addition, EBV+LPD is classified, based on the disease process , pathological and molecular data , as 3 grades:grade1, hyperplasia ( polymorphic lesions with polyclonal cells ); grade 2, borderline ( polymorphic lesions with clonality ); grade 3, neoplasm (monomorphic lesions with clonality).There are overlaps between EBV +LPD and typical hyperplasia, as well as EBV+LPD and typical lymphomas .However , the most important tasks are clinical vigilance , early identification of potential severe complications , and treating the patients in a timely manner to avoid serious complications , as well as the active treatment to save lives when the complications happened .