Objective To compare perinatal characteristics between single and twin pregnancies achieved through in vitro fertilization(IVF)versus those conceived naturally,and to evaluate their impact on pregnancy outcomes.Methods A total of 32901 women who delivered at Jinhua People's Hospital from January 2016 to December 2023 were enrolled.Participants were divided into four groups based on conception methods:IVF single pregnancy group(n=920),natural conception single pregnancy group(n=31 170),IVF twin pregnancy group(n=347),and natural conception twin pregnancy group(n=464).Multivariate Logistic regression analysis was employed to assess the effects of different conception methods on perinatal characteristics and pregnancy outcomes.Results Logistic regression analysis revealed that compared with the naturally conceived singleton group,advanced maternal age,gestational diabetes,hypothyroidism,preterm rupture of membranes,preterm birth,uterine atony,and hospitalization duration＞7d factors in IVF singleton group such as were associated with pregnancy outcomes(P＜0.05).Compared with naturally conceived twin group,IVF twin group showed correlations between intrahepatic cholestasis of pregnancy,preterm rupture of membranes,preterm birth,and pregnancy outcomes(P＜0.05).Conclusion IVF technology not only increases the proportion of twin pregnancies,but also significantly increases the risk of perinatal complications.Clinical management of IVF pregnancies requires closer monitoring and highly individualized perinatal care plans.

Objective To compare perinatal characteristics between single and twin pregnancies achieved through in vitro fertilization(IVF)versus those conceived naturally,and to evaluate their impact on pregnancy outcomes.Methods A total of 32901 women who delivered at Jinhua People's Hospital from January 2016 to December 2023 were enrolled.Participants were divided into four groups based on conception methods:IVF single pregnancy group(n=920),natural conception single pregnancy group(n=31 170),IVF twin pregnancy group(n=347),and natural conception twin pregnancy group(n=464).Multivariate Logistic regression analysis was employed to assess the effects of different conception methods on perinatal characteristics and pregnancy outcomes.Results Logistic regression analysis revealed that compared with the naturally conceived singleton group,advanced maternal age,gestational diabetes,hypothyroidism,preterm rupture of membranes,preterm birth,uterine atony,and hospitalization duration＞7d factors in IVF singleton group such as were associated with pregnancy outcomes(P＜0.05).Compared with naturally conceived twin group,IVF twin group showed correlations between intrahepatic cholestasis of pregnancy,preterm rupture of membranes,preterm birth,and pregnancy outcomes(P＜0.05).Conclusion IVF technology not only increases the proportion of twin pregnancies,but also significantly increases the risk of perinatal complications.Clinical management of IVF pregnancies requires closer monitoring and highly individualized perinatal care plans.

Objective To investigate the excretion probability,clinical characteristics of gallstones with small common bile duct stone.Methods The clinical data of 216 patients were analyzed retrospectively.The relevant clinical characteristics of small common bile duct stone's excretion were analyzed.x2 and Pearson correlation coefficient were used to analyze correlation between small common bile duct stone's excretion and relevant clinical characteristics,multiple logistic regression analysis was performed to identify these excretion related factors.Results Univariate analysis showed that patients of age less than 50 years,female sex,abdominal pain relieved and liver function recovered rapidly in 3 days of treatment,normal or slightly dilated diameter of common bile duct,single or multiple stones located in one place,stones completely located in the common bile duct or completely within the sphincter were more likely to be discharged.Multivariate analysis indicated that rapid relief of abdominal pain,rapid recovery of liver function,single or multiple stones located in one place were independently correlated with small common bile duct stone's excretion.Conclusion Small stones in common bile duct have a high probability of spontaneous removal in patients with gallstones and small common bile duct stone.