Adenoviruses are the main pathogens causing acute respiratory tract infection in infants and young children,and adenovirus types 3 and 7 infections often develop into severe pneumonia,which seriously threatens chil-dren's health and affects their quality of life.Exosomes are extracellular vesicles that possess a phospholipid bilayer struc-ture.Exosomes can be secreted and synthesized by various cells and can carry a variety of bioactive substances,such as nucleic acids and proteins.The occurrence and release of exosomes are closely related to the physiological functions of the body's cells.In recent years,studies have shown that exosomes released by patients with adenovirus infection play crucial roles in transmission and immune response activation against the virus.Therefore,in-depth research on exosomes and ade-noviruses provides new directions for the diagnosis,treatment,and clinical drug development of paediatric adenovirus pneumonia.

Adenoviruses are the main pathogens causing acute respiratory tract infection in infants and young children,and adenovirus types 3 and 7 infections often develop into severe pneumonia,which seriously threatens chil-dren's health and affects their quality of life.Exosomes are extracellular vesicles that possess a phospholipid bilayer struc-ture.Exosomes can be secreted and synthesized by various cells and can carry a variety of bioactive substances,such as nucleic acids and proteins.The occurrence and release of exosomes are closely related to the physiological functions of the body's cells.In recent years,studies have shown that exosomes released by patients with adenovirus infection play crucial roles in transmission and immune response activation against the virus.Therefore,in-depth research on exosomes and ade-noviruses provides new directions for the diagnosis,treatment,and clinical drug development of paediatric adenovirus pneumonia.