Objective:To analyze immune reconstitution and influencing factors in HIV infected men who have sex with men (MSM) with access to antiviral therapy (ART) in Guangxi Zhuang Autonomous Region (Guangxi) during 2005-2021.Methods:The data were collected from Chinese Disease Prevention and Control Information System. The study subjects were HIV infected MSM with access to the initial ART for ≥24 weeks in Guangxi from 2005 to 2021 and HIV RNA lower than the detection limit within 24 months. The proportion of infected MSM who had immune reconstitution after ART was calculated. Cox proportional hazard regression model was used to analyze the influencing factors of immune reconstitution. Software SPSS 24.0 was used for statistical analysis.Results:A total of 3 200 HIV infected MSM were enrolled, in whom 15.56 % (498/3 200) had no immune reconstitution, 14.78% (473/3 200) had moderate immune reconstitution, and the rate of complete immune reconstitution was 69.66% (2 229/3 200). The M ( Q1, Q3) of ART time for immune reconstitution was 12 (5, 27) months. Multivariate Cox proportional risk regression model analysis results showed that compared with those with initial ART at age ≥30 years, WHO clinical stage Ⅲ/Ⅳ illness, baseline BMI <18.50 kg/m 2 and baseline CD4 +T lymphocyte (CD4) counts <200 cells/μl, HIV infected MSM with initial ART at age <30 years, WHO clinical stageⅠ/Ⅱ illness, baseline BMI≥24.00 kg/m 2 and baseline CD4 counts ≥200 cells/μl were more likely to have complete immune reconstitution. Conclusions:In the HIV infected MSM in Guangxi, failures to achieve moderate and complete immune reconstitution were observed. Surveillance and ART regimen should be improved for key populations, such as those with older age and low baseline CD4 counts.

The ethical review work in hospitals has played an increasingly important role in protecting the rights and safety of subjects.However,in its practical process,there are inevitably a series of problems and difficulties,such as the need for a sound and perfect organizational structure of the ethical team,the need for detailed manage-ment system operation,and the need for standardized and innovative internal control supervision and assessment.It analyzes the practical issues of hospital ethical review and the optimisation strategies of ethical review are ex-plored based on institutional ethical perspectives to provide reference for improving the quality of ethical review in hospitals.

Objective　To understand the impact of early and timely treatment and initial antiviral treatment regimen on mortality and attrition of antiretroviral therapy. Methods A retrospective cohort study was conducted using download data on antiretroviral therapy for HIV-infected patients in Liuzhou City, Guangxi Province, from the database of the Basic Information System for AIDS Control and Prevention (BISAC) from 2010 to 2020. The Cox proportional risk regression model was used to analyze the influencing factors of mortality and attrition. Results A total of 15 713 infected patients were included, including 53.4% aged 18-<50 years, 69.4% male, 61.0% farmer, 75.1% CD4 count <350 cells /μL before initial antiviral treatment, the overall mortality rate was 4.30/100 person-years, and the overall attrition was 2.42/100 person-years. The results of Cox regression analysis showed that the influencing factors of mortality were pretreatment CD4 counts of 350-<500 cells/μL(AHR=0.72, 95%CI: 0.63-0.81) and ≥500 cells/μL (AHR= 0.64, 95%CI: 0.55-0.76); duration from diagnosis to initial antiviral treatment 91-180 days (AHR=1.25, 95%CI: 1.08-1.45), 181-365 days (AHR=1.26, 95%CI: 1.08-1.47), and ≥365 days (AHR=1.26, 95%CI: 1.11-1.44); initial antiviral treatment regimens of D4T+3TC+EFV/NVP (AHR=1.47, 95%CI: 1.32-1.63) and AZT/D4T/TDF+3TC+LPV/r (AHR=1.73, 95%CI: 1.50-1.99). Factors affecting attrition were pretreatment CD4 counts of 350-499 cells/μL (AHR=1.32, 95%CI: 1.16-1.50) and ≥500 cells/μL (AHR=1.28, 95%CI: 1.10-1.50); interval from HIV positivity confirmation to initial dosing ≥365 days (AHR=1.21, 95%CI: 1.04-1.40), initial antiviral treatment regimens of TDF+3TC+NVP (AHR=1.32, 95%CI: 1.13-1.55), AZT+3TC+EFV/NVP (AHR=1.43, 95%CI: 1.26-1.62) and AZT/D4T/TDF+3TC+LPV/r (AHR=1.33, 95CI%: 1.06-1.67). Conclusions　Early and timely treatment and the initial antiviral treatment regimen of TDF+3TC+EFV have good efficacy, but attention should be paid to the high risk of attrition of HIV-infected people with high CD4 count before treatment.

The ethical review work in hospitals has played an increasingly important role in protecting the rights and safety of subjects.However,in its practical process,there are inevitably a series of problems and difficulties,such as the need for a sound and perfect organizational structure of the ethical team,the need for detailed manage-ment system operation,and the need for standardized and innovative internal control supervision and assessment.It analyzes the practical issues of hospital ethical review and the optimisation strategies of ethical review are ex-plored based on institutional ethical perspectives to provide reference for improving the quality of ethical review in hospitals.

The ethical review work in hospitals has played an increasingly important role in protecting the rights and safety of subjects.However,in its practical process,there are inevitably a series of problems and difficulties,such as the need for a sound and perfect organizational structure of the ethical team,the need for detailed manage-ment system operation,and the need for standardized and innovative internal control supervision and assessment.It analyzes the practical issues of hospital ethical review and the optimisation strategies of ethical review are ex-plored based on institutional ethical perspectives to provide reference for improving the quality of ethical review in hospitals.

The ethical review work in hospitals has played an increasingly important role in protecting the rights and safety of subjects.However,in its practical process,there are inevitably a series of problems and difficulties,such as the need for a sound and perfect organizational structure of the ethical team,the need for detailed manage-ment system operation,and the need for standardized and innovative internal control supervision and assessment.It analyzes the practical issues of hospital ethical review and the optimisation strategies of ethical review are ex-plored based on institutional ethical perspectives to provide reference for improving the quality of ethical review in hospitals.

The ethical review work in hospitals has played an increasingly important role in protecting the rights and safety of subjects.However,in its practical process,there are inevitably a series of problems and difficulties,such as the need for a sound and perfect organizational structure of the ethical team,the need for detailed manage-ment system operation,and the need for standardized and innovative internal control supervision and assessment.It analyzes the practical issues of hospital ethical review and the optimisation strategies of ethical review are ex-plored based on institutional ethical perspectives to provide reference for improving the quality of ethical review in hospitals.

The ethical review work in hospitals has played an increasingly important role in protecting the rights and safety of subjects.However,in its practical process,there are inevitably a series of problems and difficulties,such as the need for a sound and perfect organizational structure of the ethical team,the need for detailed manage-ment system operation,and the need for standardized and innovative internal control supervision and assessment.It analyzes the practical issues of hospital ethical review and the optimisation strategies of ethical review are ex-plored based on institutional ethical perspectives to provide reference for improving the quality of ethical review in hospitals.

The ethical review work in hospitals has played an increasingly important role in protecting the rights and safety of subjects.However,in its practical process,there are inevitably a series of problems and difficulties,such as the need for a sound and perfect organizational structure of the ethical team,the need for detailed manage-ment system operation,and the need for standardized and innovative internal control supervision and assessment.It analyzes the practical issues of hospital ethical review and the optimisation strategies of ethical review are ex-plored based on institutional ethical perspectives to provide reference for improving the quality of ethical review in hospitals.

The ethical review work in hospitals has played an increasingly important role in protecting the rights and safety of subjects.However,in its practical process,there are inevitably a series of problems and difficulties,such as the need for a sound and perfect organizational structure of the ethical team,the need for detailed manage-ment system operation,and the need for standardized and innovative internal control supervision and assessment.It analyzes the practical issues of hospital ethical review and the optimisation strategies of ethical review are ex-plored based on institutional ethical perspectives to provide reference for improving the quality of ethical review in hospitals.