Objective:To explore the effect of nursing intervention based on the theory of resourcefulness in young and middle-aged patients with myocardial infarction.Methods:From January to July 2021, convenience sampling was used to select 90 young and middle-aged patients with myocardial infarction in the Department of Cardiology, Wuxi Second People's Hospital as the research object. According to the random number table, the patients were divided into the intervention group and the control group, each with 45 cases. The control group conducted conventional nursing, and the intervention group carried out intervention based on the theory of resourcefulness on the basis of conventional nursing. The Chinese version of the Post-Traumatic Growth Inventory (C-PTGI) , the Chinese version of the Event-Related Rumination Inventory (C-ERRI) , and the Connor-Davidson Resilience Scale (CD-RISC) were used to evaluate the effect of the intervention.Results:After the intervention, the total scores of C-PTGI, CD-RISC and C-ERRI in the intervention group were higher than those in the control group, and the differences were statistically significant ( t=-7.799, -4.593, -4.433; P<0.01) . Conclusions:Nursing intervention based on the theory of resourcefulness can promote the post-traumatic growth of young and middle-aged patients with myocardial infarction, adjust the level of rumination, and improve the psychological resilience of patients, which can be popularized and applied in clinical practice.

Objective:To explore the effect of continuous nursing model based on family unit in long-term warfarin anticoagulation in elderly patients with mechanical heart valve replacement (MHVR) .Methods:From July 2018 to March 2021, 87 elderly patients who underwent MHVR in Wuxi Second People's Hospital and received long-term warfarin anticoagulation after surgery were selected by convenience sampling as the research subject. The patients were divided into the observation group ( n=46) and the control group ( n=41) by random number table method. The control group adopted the routine nursing model, and the observation group adopted the family unit-based continuous nursing model on this basis. The two groups of patients were compared in terms of 3 indicators, namely treatment compliance, treatment effectiveness, and treatment safety. Results:In terms of treatment compliance, the compliance rates of smoking and drinking cessation, diet control, compliance with medicines and regular review of patients in the observation group were better than those in the control group, and the differences were statistically significant ( P<0.05) . In terms of treatment effectiveness, the international normalized ratio (INR) compliance rate and the quality of life score of the observation group were higher than that of the control group with statistical differences ( P<0.05) . In terms of treatment safety, there was no significant difference in the incidence of bleeding events and thrombosis events between the two groups ( P>0.05) . Conclusions:The continuous nursing model based on family unit is effective and safe, and can improve the compliance of elderly patients with MHVR taking warfarin after surgery, and improve the INR compliance rate and quality of life of elderly patients.

OBJECTIVE：To inv estigate the effects of 4-hydroxy-2（3H）-benzoxazolone on inflammatory and apoptosis signaling pathways in non-alcoholic fatty liver disease （NAFLD）model rats. METHODS ：SD rats were divided into normal control group（10 rats）and modeling group （50 rats）. Normal control group was given basic diet ，and modeling group were given high-fat diet to induce NAFLD model. After modeling ，the rats were divided into normal control group ，model group ，silibinin group （26.25 mg/kg），and 4-hydroxy-2（3H）-benzoxazolone high-dose ，medium-dose and low-dose groups （100，50，25 mg/kg），with 8 rats in each group. Normal control group and modeling group were given 0.6％ CMC-Na intragastrically ，and other groups were given relevant medicine 10 mL/kg intragastrically ，once a day ，for consecutive 4 weeks. After last medication ，the serum levels of albumin（ALB），total protein （TP），globulin（GLB），ALB/GLB and free fatty acid （FFA）were detected ；TUNEL staining was used to observe the apoptosis of rat hepatocytes. Western blot assay was used to detect the protein expression and phosphorylation level of inflammatory signaling pathway related proteins [Toll-like receptor 4（TLR4），myeloid differentiation factor 88（MyD88）， nuclear factor-κB p65（NF-κB p65），NF-κB inhibitor protein（IκBα）] in liver tissue as well as the expression of apoptosis signaling pathway related proteins [B cell lymphoma 2（Bcl-2），Bax，caspase-3]. RESULTS ：Compared with model group ，serum levels of TP （except for low-dose group ），GLB and FFA ，the protein expression of TLR 4（except for low-dose group ），MyD88 （except for medium-dose group ）and caspase- 3，the phosphorylation levels of NF-κB p65 and IκBα protein were decreased significantly（P＜0.05 or P＜0.01）. The ratio of A LB/GLB in serum and the ratio of Bcl- 2/Bax in liver tissue were significantly increased（P＜0.05 or P＜0.01），and the phenomenon of hepatocyte apoptosis was improved. CONCLUSIONS ：4-hydroxy-2 （3H）-benzoxazolone can ameliorate NAFLD in rats ，and the mechanism may be associated with inhibiting the expression TLR 4/ MyD88/NF-κB signaling pathway-related proteins and apoptosis-related proteins in liver tissues.

OBJECTIVE：To s tudy improvement effect and mech anism of ilicifoliosids alkaloid A （HBOA）on non-alcoholic fatty liver disease in rats. METHODS ：SD rats were randomly divided into blank control group ，model group ，Silybin capsule group（positive control ，26.25 mg/kg），HBOA high-dose ，medium-dose and low-dose groups （100，50，25 mg/kg），with 10 rats in each group. Except that blank control group fed normal feed ，the other groups were continuously fed with high-fat diet for 8 weeks to induce non-alcoholic fatty liver disease model. Form the 9th week ，blank control group and model group were given constant volume of 0.6％ CMC-Na solution ，and administration groups were given corresponding drugs by intragastric admini- stration，once a day ，for consecutive 4 weeks. The general information of rats were observed and the body weight increase ，organ （liver，kidney and spleen ）indexes were calculated ；the contents of AST ，ALT，TC，TG and NEFA in liver tissue were detected ， and SOD，GSH-Px activities and MDA content in the serum were also determined. The protein expression of PPARα in liver tissue was detected by immunohistochemistry. RESULTS ：Compared with blank control group ，the body mass increase and liver index of rats in model group were increased significantly （P＜0.01）；fat deposition could be observed in the liver ；the activities of SOD and GSH-Px in serum were reduced significantly ，and the contents of MDA ，the contents of AST ，ALT，TC，TG and NEFA in liver tissue were significantly increased ，and the protein expression of PPARα was decreased significantly（P＜0.01）. Compared with model group ，the body mass increase and liver index of the rats were decreased significantly in administration groups （P＜0.05 or P＜0.01），liver fat deposition was improved ，the activity of SOD and GSH-Px in serum （except for HBOA low-dose group ）were increased significantly while MDA content ，the contents of AST ，ALT，TC（except for HBOA low-dose group ），TG（except for HBOA low-dose group ） and NEFA in liver tissue were decreased significantl y，while protein expression of PPAR α 15177460685@163.com was increased significantly （P＜0.05 or P＜0.01）. Some of the above indexes of HBOA high-dose group were 电话：0771-5302433。E-mail：junlin898@126.com significantly better than HBOA medium- and low-dose group（P＜0.05）. CONCLUSIONS ：HBOA has a certain improvement effect on non-alcoholic fatty liver disease in rats caused by high-fat diet ，and its mechanism may be related to improving lipid metabolism disorders ，anti-oxidative stress and up-regulating the expression of PPARα.

Objective? To explore the relationship between compliance of analgesic drugs and self-management efficacy in patients with lung cancer, and to provide reference for formulating targeted interventions. Methods? A total of 287 cases of lung cancer patients in the Second Hospital of Wuxi Affiliated to Nanjing Medical University from January 2015 to December 2017 were recruited by convenience sampling method. General information questionnaire, Morisky Medication Adherece Scale and the Chinese version of Strategies Used by People to Promote Health (C-SUPPH) were applied to investigate the level of self-management efficacy and medication compliance status, so as to analyze the relationship between self-management efficacy and medication compliance. Results? The score of self-management efficacy of the 287 lung cancer patients was (91.58±28.06), and the score of medication compliance was (6.04±1.23). The correlation analysis showed that the positive attitude dimension, the stress reduction dimension and the making decisions dimension in C-SUPPH were all positively correlation with medication compliance (r=0.607, 0.497, 0.374; P＜ 0.01). Multivariate linear regression analysis showed that age, comorbidity and self-management efficacy were the influencing factors of medication compliance of analgesic drugs in patients with lung cancer (P＜0.01). Conclusions? The compliance of lung cancer patients with analgesics needs to be improved. Patient's medication compliance increases with the self-management efficacy. Therefore, health education can strengthen patient's self-management efficacy, so as to improve patient's medication compliance.

Objective? To investigate the effect of the cardiac rehabilitation program based Omaha system on patients after percutaneous coronary intervention (PCI). Methods? A convenient sampling method was used to select 127 patients from the Department of Cardiology of Wuxi Second People's Hospital from October 2017 to April 2018. According to the patient's hospitalization number, they were randomly divided into two groups, including 64 in the experimental group and 63 in the control group. During the intervention, 2 patients were lost in the experimental group and 1 patient was lost in the control group. There were 62 patients in each group to complete the study. Patients in the control group received routine care, while patients in the experimental group received cardiac rehabilitation based on the Omaha system. The effect of the intervention was measured by 6 min exercise test, secondary prevention knowledge and behavior questionnaire for post-PCI patients. Results? After the intervention, The 6-minute exercise distance was (439.28±67.94) m in the experimental group, and it was (315.62±45.18) m in the control group. The exercise endurance of the experimental group was higher than that of the control group, and the difference was statistically significant (t=11.934, P＜ 0.01). The secondary prevention knowledge and behavior scores of the experimental group were (87.21±12.46) and (84.27±14.58), which were higher than those of the control group (71.30±8.12) and (65.94±8.97). The differences were statistically significant (t=8.423, 8.431; P ＜0.01). Conclusions? Cardiac rehabilitation programs based Omaha system can improve exercise endurance and secondary prevention behaviors of patients after PCI and its application should be promoted.

Objective To explore the application effect of motivational interview combined with transtheoretical model in self-care of patients with coronary heart disease. Methods From August 2016 to April 2017, a total of 77 patients with coronary heart disease diagnosed in Wuxi Second Hospital Affiliated to Nanjing Medical University were selected by convenience sampling method, and randomly divided into control group (n=38) and observation group (n=39) by random number table. The two groups were given traditional health education and motivational interview combined with transtheoretical model health education. The self-efficacy, self-management ability, ejection fraction and regional wall motion abnormality (RWMA) were compared between the two groups before and after intervention. Results The scores of self-efficacy and self-management ability of patients with coronary heart disease in the observation group were (39.12±5.98) and (88.88±5.01) respectively, which were significantly higher than those in the control group (31.04±6.59) and (81.00±4.25). The differences were statistically significant (P＜0.01). The ejection fraction of the observation group was higher than that of the control group, and the number of RWMA cases in the control group was higher than that in the observation group. The difference was statistically significant (P＜0.05). Conclusions Using motivated interviews combined with cross-theoretical models in self-care of patients with coronary heart disease can effectively improve patients' self-efficacy and self-management ability,it is worthy of clinical promotion.

OBJECTIVETo investigate the effect and safety of acupuncture with regulating menstruation to promote pregnancy for diminished ovarian reverse (DOR).

METHODSAccording to prospective case series, 46 patients were observed and finally 40 cases were included. The acupoints were ① Baihui (GV 20), Shenting (GV 24), Guanyuan (CV 4) and bilateral Benshen (GB 13), Huangshu (KI 16), Dahe (KI 12), Luanchao (Extra), Zusanli (ST 36), Sanyinjiao (SP 6), Taixi (KI 3), Taichong (LR 3) and ② bilateral Shenshu (BL 23) and Ciliao (BL 32). The points in the two groups were used alternately. Acupuncture was given for 3 courses, 12 times as a course and 3 times a week. Before and after treatment, and 3 months after treatment, follicle-stimulating hormone (FSH), follicle-stimulating hormone/luteinizing hormone (FSH/LH), estradiol (E), antral follicle count (AFC) and TCM symptom score were observed. The safety was evaluated.

RESULTSCompared with before treatment, the levels of FSH, FSH/LH decreased, and the levels of Eand AFC increased after treatment and at follow-up (all<0.05). And the TCM symptom scores were significantly lower than those before treatment (both<0.05). The rate of pregnancy after treatment was 15% (6/40). There was no infection and organ injury.

CONCLUSIONAcupuncture with regulating menstruation to promote pregnancy can safely improve the ovarian reserve of patients with DOR.

Objective To explore the application value of the situation-background-assessment-recommendation(SBAR) communication mode in the patients with acute myocardial infarction (AMI).Methods Ninety-four cases of AMI patients who were hospitalized in the department of cardiology in Wuxi No.2 People's Hospital of Nanjing Medical University were included and were randomly divided into the conventional group and the SBAR group. There were 47 cases in each group. The patients in the conventional group were given the routine care; the patient in the SBAR group was given the SBAR communication mode. The nursing satisfaction and the incidence of adverse events in the 2 groups were compared.Results The nursing satisfaction in the SBAR group was 95.74%, which was significantly higher compared to the conventional group (70.21%,P<0.05). The total incidence of adverse events in the SBAR group was 4.25%; in the conventional group the incidence was 25.53%. The difference between the 2 group was significant (χ2=6.42,P<0.05).Conclusions The SBAR communication model can effectively improve the quality of the nurses' disease observation and the nursing satisfaction and reduce the incidence of clinical adverse events, which was worth clinical promotion.

Objective To compare the effects of fluid therapy by "measurement" water dispenser and routine fluid therapy on standard fluid therapy among patients with percutaneous coronary intervention (PCI) in coronary care unit (CCU). Methods A total of 204 patients with PCI were divided into observation group (n=102) and control group (n=102) by random number table. Patients in the observation group received drinking water plan according to regulatory requirements using the self-designed "measurement" water dispenser. Patients in the control group accepted nursing plan of routine drinking fluid therapy. This study compared the qualified rate of standardized drinking water, patient satisfaction, renal function and the incidence of contrast-induced nephropathy (CIN) three days after intervention between two groups. Results There were 102 (100.00%) qualified patients drinking water according to stipulations in the observation group, while there were 68 (66.67%) in the control group. The qualified rate of drinking water in the observation group was higher than that in the control group with a significant difference (χ2=38.4, P<0.01). There were two patients with contrast induced nephropathy in the observation group, and eight patients with contrast induced nephropathy in the control group (χ2=4.2,P=0.04). Conclusions The effect of fluid therapy by "measurement" water dispenser supplemented with diversified education is satisfactory among patients with PCI in CCU.