Objective To investigate the clinical value of myocardial contrast echocardiography(MCE)quantitative analysis in diagnosing myocardial microcirculation disorders in coronary artery disease and evalua-ting outcomes after percutaneous coronary intervention(PCI).Methods Fifty patients diagnosed with severe stenosis of a single or more coronary arteries(stenosis rate of over 75%)through coronary CT angiography(CTA)or coronary angiography(CAG)from June 2022 to June 2024 were selected as the coronary heart dis-ease group.Thirty patients with coronary artery lesions complicated with myocardial infarction who under-went PCI treatment were selected as the post PCI group.Eighty patients with normal or only mild coronary artery stenosis(stenosis rate below 50%)were selected as the control group.All participants underwent MCE examination.Quantitative parameters,including peak intensity(A),upslope rate(β),time-to-peak(TTP),ar-ea under the curve(MCE-ACU),regional myocardial blood flow(MBF=A×β),and left ventricular ejection fraction(LVEF),were analyzed using ROI software in both normal and lesion-supplied myocardial regions.Receiver operating characteristic(ROC)was used to analyze the diagnostic value of various parameters of MCE for myocardial micro perfusion caused by coronary artery disease and myocardial perfusion after PCI.Re-sults Quantitative MCE parameters were significantly lower in the coronary heart disease group and post-PCI groups compared to the control group(P<0.05),with the post-PCI group showing the lowest values.Except for TTP,all parameters differed significantly between groups(P<0.05).Despite successful stent placement(TIMI grade 3 flow)in lesion vessels post-PCI,A,β,and MCE-ACU remained reduced in lesion-supplied re-gions compared to normal territories(P<0.05).The ROC curve showed that MCE parameters A,β,and MBF had independent diagnostic value for myocardial microcirculation disorders in coronary heart disease.The sensitivity and specificity of multi parameter combined diagnosis of myocardial microcirculation disorders in coronary heart disease were significantly improved,and MCE parameters were correlated with left ventricu-lar systolic function.Conclusion MCE quantitative analysis provides significant diagnostic value for myocardi-al microcirculation disorders in coronary artery disease patients and effectively evaluates PCI therapeutic effi-cacy and long-term prognosis.