Objective To explore the factors affecting the quality of psychological assistance hotline connections in Shaanxi Province, and to provide a basis for optimizing services. Methods A total of 149 calls with suicidal tendencies were included from January to March 2022, and data were collected by 31 trained assessors through standardized questionnaires (general information, suicide risk, emotional intensity, and wiring characteristics). Results The results showed that 56.38% of the callers were female, with age groups concentrated between ≤ 18 years old (29.53%) and 19-34 years old (43.62%). The call duration was mainly between 31 and 45 minutes (50.34%). Operators conducted a suicide risk assessment on the callers, with 38.9% having a comprehensive assessment, 38.9% having an incomplete assessment, and 22.1% having no assessment. The main mental disorders of the callers were depression (48.32%), anxiety (15.44%), and bipolar disorder (14.77%), with 25.50% having comorbidities of ≥ 2 disorders. Emotional scores were as follows: depression (4.11 ± 0.76), sadness (3.97 ± 1.03), and despair (3.78 ± 1.05). There were significant differences in depression, anger, despair, and sadness among the callers with different levels of danger (t=4.79, 3.35, 15.79, 4.24, all P<0.05). Women had higher levels of fear than men (t=3.10, P<0.01). The longer the call duration, the higher the level of despair (t=5.66, P<0.01). Multiple regression analysis showed that incomplete suicide risk assessment by operators (B=-2.36), general procedures for operators' connections (B=5.44), and technical factors (B=2.01) significantly affected the quality of psychological assistance hotlines (all P<0.05). Conclusion Callers with suicidal tendencies generally have serious mental and psychological problems and prominent negative emotions. Strengthening the suicide risk assessment ability of operators and standardizing processes and service attitudes are key to improving the quality of psychological assistance hotlines.

Aging is an inevitable, physiological process of the human body, leading to deterioration in bodily function and increased susceptibility to various diseases. Effective endogenous therapeutic strategies for anti-aging and related diseases remain limited. Exercise confers multifaceted benefits to physical health by augmenting osteogenic and myogenic processes, enhancing cardiovascular and nervous system function, and attenuating chronic inflammation. Angiogenesis and lymphangiogenesis play pivotal roles in anti-aging, tissue repair, and immune response modulation, underscoring their potential as therapeutic targets for age-related diseases. Modulating angiogenic and lymphangiogenic pathways may provide a promising strategy for mitigating vascular decline and immune system dysfunction associated with aging. Exercise-induced endogenous angiogenesis and lymphangiogenesis can exert beneficial effects on physiological function, thereby representing a potential therapeutic paradigm for combating age-related decline and diseases. This review offers a thorough summary of the present knowledge regarding angiogenesis and lymphangiogenesis induced by exercise, encompassing the underlying mechanisms and the effects in different organs. In addition, it explores the potential of physical activity as a non-pharmacological intervention for anti-aging strategies and disease management, offering novel insights into the intersection of physical activity, aging, and disease progression.
Humans ; Lymphangiogenesis/physiology* ; Aging/physiology* ; Exercise/physiology* ; Animals ; Neovascularization, Physiologic/physiology* ; Angiogenesis

Objective:To investigate the incidence of shoulder work-related musculoskeletal disorders (WMSDs) among occupational population in China, and to explore their intrinsic association with personal and work-related factors.Methods:In April 2024, 73497 valid questionnaires of the Chinese version of the Musculoskeletal Disorders Electronic Questionnaire were retrospectively analyzed from June 2018 to December 2023 in 22 provinces and 29 key industries in China, and the general information, occurrence of WMSDs and related risk factors of key occupational populations in different regions in China were collected. By using Chi-square test and confirmatory factor analysis, the relationship between shoulder fatigue and pain in key occupational groups and individual factors, work type, work posture and work organization was discussed, and the internal relationship was analyzed based on structural equation model.Results:Higher incidence of shoulder fatigue and pain were associated with female, lack of physical exercise, uncomfortable working posture and neck leaning forward ( P<0.05). Structural equation model analysis showed that work type, work posture and work organization were strongly correlated ( r=0.58, 0.55). Work organization and work type were strongly correlated with shoulder fatigue ( r=0.65) and moderately correlated with shoulder fatigue ( r=0.21). Shoulder fatigue was moderately associated with shoulder pain ( r=0.40). Individual factors, work type, work posture and shoulder fatigue could directly affect shoulder pain ( OR=0.07, -0.09, 0.17 and 0.40), and work type and work posture could also indirectly affect shoulder pain through shoulder fatigue ( OR=0.08, 0.03). Work organization only indirectly affected shoulder pain through shoulder fatigue ( OR=0.26) . Conclusion:The main influencing factor of shoulder pain is shoulder fatigue, followed by work posture and individual factors. Structural equation model can better reflect the complex relationship between work type, work posture and work organization and shoulder WMSDs. Improving work posture and work organization may be an effective way to control the influence of shoulder fatigue on shoulder pain.

Objective:To explore the structural equation model to explore the levels of work-related musculoskeletal disorders (WMSDs) and various risk factors in the feet and ankle of China's occupational population, providing scientific basis for for preventing WMSDs in feet and ankles.Methods:Data of 73497 national occupational epidemiological cases were selected from June 2018 to December 2023 used the Chinese version of the Electronic Questionnaire on Musculoskeletal Disorders. The adverse ergonomic factors and their source classification standard and confirmatory factor analysis were used to investigate foot and ankle WMSDs and their related risk factors (including individual factors, work organization, work posture, work type, fatigue, etc.) in key occupational groups in China, and structural equation model hypothesis, fitting, verification, and path and intermediary effect analysis were carried out. The model fit evaluation indexes included Chi-square specific degrees of freedom ( χ2/ df), gauge fit index (NFI), Tucker Lewis index (TLI), goodness of Fit index (GFI), adjusted Goodness of Fit index (AGFI) and approximate root mean square error (RMSEA) . Results:A total of 73497 occupational workers were surveyed, with local muscle fatigue and WMSDs incidence rates in the feet and ankles being 17.17% and 12.06%, respectively. The fitting index of the adjusted structural equation model basically meets the standard (GFI=1, AGFI=1, RMESA=0.042, NFI=0.716, TLI=0.663). The top three factors affecting feet and ankle WMSDs are feet and ankle muscle fatigue, work type, and work organization, with standardized path coefficients of 0.221, 0.105, and 0.095, respectively. The top two factors affecting feet and ankle muscle fatigue are work organization and work type, with standardized path coefficients of 0.548 and 0.383, respectively. Feet and ankle muscle fatigue, work type, work organization, and work posture have a direct effect on feet and ankle WMSDs, with effect values of 0.221, 0.105, 0.095, and 0.077, respectively. The organization and type of work can also have indirect effects through feet and ankle muscle fatigue, with effect values of 0.121 and 0.084, respectively.Conclusion:Feet and ankle muscle fatigue has a direct impact on WMSDs, and plays a mediating role between ankle and ankle WMSDs caused by work organization and work type. Feet and ankle muscle fatigue is an important pathway leading to feet and ankle WMSDs. It is recommended that employers and managers detect job fatigue early and take corresponding prevention and intervention measures, which can play a key role in preventing feet and ankle WMSDs.

Objective:To explore the structural relationship between WMSDs in the upper limbs and various risk factors in the occupational population in China, based on a large sample epidemiological survey and structural equation analysis, and to establish a structural equation model, so as to lay a foundation for the prevention and control of such diseases.Methods:The Chinese version of the Musculoskeletal Disorders Electronic Questionnaire was used to conduct a nationwide survey on the prevalence of WMSDs in the upper extremity. Six factors related to WMSDs in the upper extremity were extracted by the classification standard of adverse ergonomic factors and their source and confirmatory factor analysis, including work organization, work type, upper extremity work posture, individual factors, upper extremity fatigue and upper extremity WMSDs. The structural equation analysis was carried out and the structural equation model was established.Results:The incidence of WMSDs and fatigue in the upper limbs was 24.44% and 43.76%, respectively. The adjusted structural equation model fitting indicators were generally up to the standard (GFI=1.000, AGFI=1.000, RMSEA=0.043, NFI=0.808, TLI=0.784) . The four exogenous latent variables of work organization, work type, upper limb work posture and individual factors were correlated. There was a strong positive correlation between job type and upper limb work posture ( r=0.865) , a moderate positive correlation between work organization and job type and upper limb work posture ( r=0.570, 0.490) , and a weak negative correlation between individual factors and the other three exogenous latent variables. Upper limb work posture and individual factors had direct effects on upper limb WMSDs, and the effect coefficients were 0.10 and 0.06, respectively. Upper limb fatigue played a mediating role between work organization, work type, upper limb work posture and upper limb WMSDs. The effect coefficient was 0.46, and the composition ratios of indirect effects were 100.0%, 100.0%, and 38.3%, respectively. The direct path effect of upper limb work posture, individual factors and upper limb WMSDs was weaker than the mediating path through upper limb fatigue. Conclusion:When carrying out the prevention and control of upper limbWMSDs, it is necessary to comprehensively consider the pathogenesis path of upper limb muscle fatigue and upper limb WMSDs caused by work organization, work type, and upper limb work posture, so as to provide theoretical reference for improving the prevention and control level of such diseases.

Objective:To investigate the expression and clinical relevance of MicroRNA(miRNA)-21 and miRNA-22 in urine exosomes of patients diagnosed with contrast-induced nephropathy(CIN).Methods:A total of 258 patients who underwent coronary intervention at our hospital's Department of Cardiology between July 2020 and July 2023 were retrospectively selected.These patients were divided into a CIN group( n=68)and a non-CIN group( n=190)based on the occurrence of contrast-induced nephropathy(CIN)post-coronary intervention.Clinical data from both groups were collected and compared, and levels of miRNA-21 and miRNA-22 in urinary exosomes were detected using polymerase chain reaction.Binary logistic regression was then utilized to analyze the risk factors associated with CIN.Furthermore, the diagnostic accuracy of urine exosomal miRNA-21 and miRNA-22 in detecting CIN was assessed through a receiver operating characteristic(ROC)curve. Results:Various risk factors were identified for contrast-induced nephropathy(CIN)in the study, including age(≥70 years old, 48.5%), diabetes(52.9%), myocardial infarction(11.8%), hypotension(17.7%), reduced glomerular filtration rate(GFR)[≤60 ml·min -1·1.73(m -1) 2, 32.4%], decreased left ventricular ejection fraction(LVEF)(≤0.45, 16.2%), high contrast agent dosage(>200 ml, 17.7%), elevated serum creatinine(Scr)levels 24 hours post-coronary intervention in the CIN group[(76.5±4.5)μmol/L], as well as higher levels of urine exosomal miRNA-21(0.9±0.2)and miRNA-22(5.9±1.1)between CIN group and non-CIN group[32.6%, 32.1%, 2.6%, 5.8%, 18.9%, 5.8%, 5.3%, (68.4±3.3)mol/L, (0.8±0.2), (3.1±0.90]( t=5.441, 9.266, 8.730, 8.671, 5.164, 6.927, 9.846, 8.707, 3.040, 11.233, all P<0.05).Logistic regression analysis showed that age ≥70 years( OR: 3.611, 95% CI: 1.235-10.561), diabetes( OR: 5.886, 95% CI: 1.601-21.641), myocardial infarction( OR: 3.600, 95% CI: 1.204-10.763), hypertension( OR: 6.672, 95% CI: 1.761-25.281), GFR≤60 ml·min -1·1.73(m -1) 2( OR: 3.413, 95% CI: 1.086-10.732), LVEF≤0.45( OR: 5.008, 95% CI: 1.380-18.178), dosage of contrast agent >200mL( OR: 3.389, 95% CI: 1.016-11.299), elevated Scr 24 hours after operation( OR: 0.597, 95% CI: 0.478-0.746)and high expression of miRNA-21( OR: 0.014, 95% CI: 0.001-0.292)and miRNA-22( OR: 0.017, 95% CI: 0.001-0.294)in urine exosomes were the risk factors for CIN(all P<0.05).The AUC of urinary exocrine miRNA-21 and miRNA-22 in the diagnosis of CIN were 0.694 and 0.950, respectively, and the AUC of combined diagnosis was 0.967. Conclusions:The expression levels of miRNA-21 and miRNA-22 in urinary exosomes of patients with contrast-induced nephropathy(CIN)are significantly elevated, indicating their potential clinical relevance in predicting CIN.Simultaneous assessment of both miRNAs can enhance the precision of CIN identification.

Objective:To investigate the expression and clinical relevance of MicroRNA(miRNA)-21 and miRNA-22 in urine exosomes of patients diagnosed with contrast-induced nephropathy(CIN).Methods:A total of 258 patients who underwent coronary intervention at our hospital's Department of Cardiology between July 2020 and July 2023 were retrospectively selected.These patients were divided into a CIN group( n=68)and a non-CIN group( n=190)based on the occurrence of contrast-induced nephropathy(CIN)post-coronary intervention.Clinical data from both groups were collected and compared, and levels of miRNA-21 and miRNA-22 in urinary exosomes were detected using polymerase chain reaction.Binary logistic regression was then utilized to analyze the risk factors associated with CIN.Furthermore, the diagnostic accuracy of urine exosomal miRNA-21 and miRNA-22 in detecting CIN was assessed through a receiver operating characteristic(ROC)curve. Results:Various risk factors were identified for contrast-induced nephropathy(CIN)in the study, including age(≥70 years old, 48.5%), diabetes(52.9%), myocardial infarction(11.8%), hypotension(17.7%), reduced glomerular filtration rate(GFR)[≤60 ml·min -1·1.73(m -1) 2, 32.4%], decreased left ventricular ejection fraction(LVEF)(≤0.45, 16.2%), high contrast agent dosage(>200 ml, 17.7%), elevated serum creatinine(Scr)levels 24 hours post-coronary intervention in the CIN group[(76.5±4.5)μmol/L], as well as higher levels of urine exosomal miRNA-21(0.9±0.2)and miRNA-22(5.9±1.1)between CIN group and non-CIN group[32.6%, 32.1%, 2.6%, 5.8%, 18.9%, 5.8%, 5.3%, (68.4±3.3)mol/L, (0.8±0.2), (3.1±0.90]( t=5.441, 9.266, 8.730, 8.671, 5.164, 6.927, 9.846, 8.707, 3.040, 11.233, all P<0.05).Logistic regression analysis showed that age ≥70 years( OR: 3.611, 95% CI: 1.235-10.561), diabetes( OR: 5.886, 95% CI: 1.601-21.641), myocardial infarction( OR: 3.600, 95% CI: 1.204-10.763), hypertension( OR: 6.672, 95% CI: 1.761-25.281), GFR≤60 ml·min -1·1.73(m -1) 2( OR: 3.413, 95% CI: 1.086-10.732), LVEF≤0.45( OR: 5.008, 95% CI: 1.380-18.178), dosage of contrast agent >200mL( OR: 3.389, 95% CI: 1.016-11.299), elevated Scr 24 hours after operation( OR: 0.597, 95% CI: 0.478-0.746)and high expression of miRNA-21( OR: 0.014, 95% CI: 0.001-0.292)and miRNA-22( OR: 0.017, 95% CI: 0.001-0.294)in urine exosomes were the risk factors for CIN(all P<0.05).The AUC of urinary exocrine miRNA-21 and miRNA-22 in the diagnosis of CIN were 0.694 and 0.950, respectively, and the AUC of combined diagnosis was 0.967. Conclusions:The expression levels of miRNA-21 and miRNA-22 in urinary exosomes of patients with contrast-induced nephropathy(CIN)are significantly elevated, indicating their potential clinical relevance in predicting CIN.Simultaneous assessment of both miRNAs can enhance the precision of CIN identification.

Objective:To investigate the incidence of shoulder work-related musculoskeletal disorders (WMSDs) among occupational population in China, and to explore their intrinsic association with personal and work-related factors.Methods:In April 2024, 73497 valid questionnaires of the Chinese version of the Musculoskeletal Disorders Electronic Questionnaire were retrospectively analyzed from June 2018 to December 2023 in 22 provinces and 29 key industries in China, and the general information, occurrence of WMSDs and related risk factors of key occupational populations in different regions in China were collected. By using Chi-square test and confirmatory factor analysis, the relationship between shoulder fatigue and pain in key occupational groups and individual factors, work type, work posture and work organization was discussed, and the internal relationship was analyzed based on structural equation model.Results:Higher incidence of shoulder fatigue and pain were associated with female, lack of physical exercise, uncomfortable working posture and neck leaning forward ( P<0.05). Structural equation model analysis showed that work type, work posture and work organization were strongly correlated ( r=0.58, 0.55). Work organization and work type were strongly correlated with shoulder fatigue ( r=0.65) and moderately correlated with shoulder fatigue ( r=0.21). Shoulder fatigue was moderately associated with shoulder pain ( r=0.40). Individual factors, work type, work posture and shoulder fatigue could directly affect shoulder pain ( OR=0.07, -0.09, 0.17 and 0.40), and work type and work posture could also indirectly affect shoulder pain through shoulder fatigue ( OR=0.08, 0.03). Work organization only indirectly affected shoulder pain through shoulder fatigue ( OR=0.26) . Conclusion:The main influencing factor of shoulder pain is shoulder fatigue, followed by work posture and individual factors. Structural equation model can better reflect the complex relationship between work type, work posture and work organization and shoulder WMSDs. Improving work posture and work organization may be an effective way to control the influence of shoulder fatigue on shoulder pain.

Objective:To explore the structural equation model to explore the levels of work-related musculoskeletal disorders (WMSDs) and various risk factors in the feet and ankle of China's occupational population, providing scientific basis for for preventing WMSDs in feet and ankles.Methods:Data of 73497 national occupational epidemiological cases were selected from June 2018 to December 2023 used the Chinese version of the Electronic Questionnaire on Musculoskeletal Disorders. The adverse ergonomic factors and their source classification standard and confirmatory factor analysis were used to investigate foot and ankle WMSDs and their related risk factors (including individual factors, work organization, work posture, work type, fatigue, etc.) in key occupational groups in China, and structural equation model hypothesis, fitting, verification, and path and intermediary effect analysis were carried out. The model fit evaluation indexes included Chi-square specific degrees of freedom ( χ2/ df), gauge fit index (NFI), Tucker Lewis index (TLI), goodness of Fit index (GFI), adjusted Goodness of Fit index (AGFI) and approximate root mean square error (RMSEA) . Results:A total of 73497 occupational workers were surveyed, with local muscle fatigue and WMSDs incidence rates in the feet and ankles being 17.17% and 12.06%, respectively. The fitting index of the adjusted structural equation model basically meets the standard (GFI=1, AGFI=1, RMESA=0.042, NFI=0.716, TLI=0.663). The top three factors affecting feet and ankle WMSDs are feet and ankle muscle fatigue, work type, and work organization, with standardized path coefficients of 0.221, 0.105, and 0.095, respectively. The top two factors affecting feet and ankle muscle fatigue are work organization and work type, with standardized path coefficients of 0.548 and 0.383, respectively. Feet and ankle muscle fatigue, work type, work organization, and work posture have a direct effect on feet and ankle WMSDs, with effect values of 0.221, 0.105, 0.095, and 0.077, respectively. The organization and type of work can also have indirect effects through feet and ankle muscle fatigue, with effect values of 0.121 and 0.084, respectively.Conclusion:Feet and ankle muscle fatigue has a direct impact on WMSDs, and plays a mediating role between ankle and ankle WMSDs caused by work organization and work type. Feet and ankle muscle fatigue is an important pathway leading to feet and ankle WMSDs. It is recommended that employers and managers detect job fatigue early and take corresponding prevention and intervention measures, which can play a key role in preventing feet and ankle WMSDs.