1.Effect of low high-density lipoprotein levels on mortality of septic patients: A systematic review and meta-analysis of cohort studies
Shao-hua Liu ; Huo-yan Liang ; Hong-yi Li ; Xian-fei Ding ; Tong-wen Sun ; Jing Wang
World Journal of Emergency Medicine 2020;11(2):109-116
BACKGROUND: An increase in high-density lipoprotein (HDL) is well associated with a decreased cardiovascular risk, especially atherosclerosis. Recent studies suggest that lower levels of HDL may also be associated with an increased risk of sepsis and an increased rate of mortality in septic patients. However, this conclusion remains controversial.
METHODS: MEDLINE, EMBASE, and CENTRAL databases were searched from inception to September 30, 2019. All studies were conducted to evaluate the correlation of lipoprotein levels and the risk and outcomes of sepsis in adult patients. The primary outcomes were the risk and mortality of sepsis.
RESULTS: Seven studies comprising 791 patients were included. Lower levels of HDL had no marked relevance with the risk of sepsis (odds radio [OR] for each 1 mg/dL increase, 0.94; 95% CI 0.86–1.02; P=0.078), whereas lower HDL levels were related to an increased mortality rate in septic patients (OR for below about median HDL levels, 2.00; 95% CI 1.23–3.24; P=0.005).
CONCLUSION: This meta-analysis did not reveal a significant association between lower HDL levels and an increase in the risk of sepsis, whereas it showed that lower HDL levels are associated with a higher mortality rate in septic adult patients. These findings suggest that HDL may be considered as a promising factor for the prevention and treatment of sepsis in the future.
2.Thinking on the development of Shanxi Provincial Cancer Hospital for 67 years
Shijun HUO ; Xuqing LI ; Wenwen WANG ; Hua LANG
Cancer Research and Clinic 2019;31(7):484-485
Shanxi Provincial Cancer Hospital has a history of 67 years. The continuous development of the hospital reflects the tremendous advances of cancer prevention and treatment in China. The article reviews the development process of Shanxi Provincial Cancer Hospital and puts forward some ideas for hospital development under the new situation.
3.Endovascular intervention for late postpancreaticoduodenectomy hemorrhage
Yanmiao HUO ; Jiachang CHI ; Jianyu YANG ; Wei LIU ; Junfeng ZHANG ; Yongwei SUN ; Rong HUA
Chinese Journal of General Surgery 2019;34(3):208-212
Objective To evaluate the safety,efficacy of interventional treatment for late postpancreaticoduodenectomy hemorrhage (LPPH).Methods From Jan 2008 to Dec 2017,678 patients underwent pancreaticoduodenectomy (PD).33 patients (4.9%) suffered from LPPH.30 of these 33 patients underwent diagnostic angiography and endovascular treatment,either transcatheter arterial embolization (TAE,n =21) or covered stent placement (CSP,n =9),and the other 3 underwent laparotomy.Results The incidence of LPPH is 4.9% with a 12% motality.The most common presentation is bleeding from abdominal drainage (24.2%) and melena (24.2%).The incidence of sentinel bleeding (SB) is 45.5% and postoperative pancreatic fistula (POPF) is 69.7%.Intra-abdominal infection were identified in 24 patients (72.7%) and the most common pathogenic bacteria is pseudomonas aeruginosa (11/24,45.8%).The mean time between PD operation and LPPH was 17.4 days.In 21 patients receiving TAE,4 got liver damage and 2 with liver abscesses,1 died.The most common site of LPPH is GDA stump and re-bleeding occurred in 5 patients.9 patients by CSP got bleeding under control.In all 7 re-bleeding patients,2 were saved by CSP,1 was saved by TAE,while the other 4 died.Conclusion Early intervention plays an important role for LPPH.CSP is better than TAE.
4.Progress in the application of pulmonary surfactant instillation via fine catheter technology
Mengyue HUO ; Hua MEI ; Chunzhi LIU
Chinese Pediatric Emergency Medicine 2019;26(8):618-622
With the improvement of the treatment of neonatal respiratory distress syndrome,minimal-ly invasive pulmonary surfactant(PS)therapy is gradually considered to be a more ideal drug delivery method for PS because of its simpler operation and less airway damage,and it is a part of the lung protective strategy for premature infants. Therefore,this article reviewed the administration methods,advantages,research status and future problems of minimally invasive PS treatment technology.
5.Evaluation of the effect of continuous quality improvement measures for premature infants in neonatal intensive care unit
Yayu ZHANG ; Mengyue HUO ; Dan SONG ; Mengtian ZHAO ; Hua MEI
Chinese Journal of Postgraduates of Medicine 2019;42(6):537-540
Objective To explore the effective measures to reduce the incidence of nosocomial infection through the implementation of continuous quality improvement measures in the neonatal intensive care unit (NICU). Methods One hundred and twenty-two premature infants hospitalized in NICU of the Affiliated Hospital of Inner Mongolia Medical University after continuous quality improvement from January 2018 to November 2018 were selected prospectively as the experimental group, and 125 premature infants using routine nursing management mode from March 2017 to December 2017 were selected as the control group. The occurrence of bloodstream infection in two groups was observed. Results The incidence of bloodstream infection in the experimental group [7.4%(9/122)] was significantly lower than that in the control group [17.6%(22/125)], and the difference was statistically significant (P=0.015). Compared with the control group, the experimental group had statistically significant differences in implementation rate of hand hygiene, average days of peripherally insterted central catheter indwelling, and antibiotic use rate and average days (P < 0.01). Conclusions The incidence of bloodstream infections in NICU can be effectively controlled through strict continuous quality improvement measures.
6.Prevalence and Rates of New Diagnosis and Missed Diagnosis of Diabetes Mellitus among 35-74-year-old Residents in Urban Communities in Southwest China.
Xin CAO ; Min YANG ; Xiao Bo HUANG ; Xue Ling TAN ; Ya LIU ; Nan HUO ; Ming Sheng CHEN ; Wei Wei TANG ; Xiao MA ; Rong Hua XU
Biomedical and Environmental Sciences 2019;32(9):704-709
7.Energy Demand and Its Regulatory Mechanism during Folliculogenesis.
Hao Yan TU ; Xiao Can LEI ; Peng HUO ; Jiang Hua LE ; Shun ZHANG
Acta Academiae Medicinae Sinicae 2019;41(3):408-414
The growth and development of follicles are regulated by genes,hormones and growth factors autocrined and paracrined from granulosa cells,theca cells,and oocytes.Products of glycolysis from granulosa cells such as pyruvate and lactate are one of the main energy sources,which play an important role during folliculogenesis and follicle maturity.Studies on the changes of the products and rate-limiting enzymes during granulosa cells' glycolysis help to clarify the molecular mechanism of energy demand in folliculogenesis and guide the clinical treatment of infertility due to abnormal follicular development.This article reviews recent research advances in the energy demand and regulatory mechanism in different states of folliculogenesis.
Energy Metabolism
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Female
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Glycolysis
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Granulosa Cells
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Humans
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Intercellular Signaling Peptides and Proteins
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Oocytes
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Ovarian Follicle
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growth & development
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Theca Cells
8.Effect of fresh Gastrodia elata on gut microbiota in mice.
Zhong-Yi HUA ; Hong-Mei LI ; Jian-Hui SUN ; Hai-Ru HUO ; Xiao-Qin LI ; Lu-Qi HUANG ; Yuan YUAN
China Journal of Chinese Materia Medica 2019;44(5):1004-1009
Gastrodia elata B1.,a traditional Chinese medicine,was frequently applied as a cure for headache or migraine. Its effects include suppressing hyperactive liver,calming endogenous wind,dredging collateralsand relieving spasm. There has been a proportion that G. elata should be added to The List of Substances That Are Traditionally Both Food and Chinese Medicinal Materials. The dry G. elata was commonly used in clinic,which have some fundamental study on efficacy and mechanism. However,fresh G. elata,which was added to herbal cuisine very often,lacks corresponding research. The interaction of diet,microbiota and human is a hot issue and lots of scholars are focusing on it. This research sequenced the 16 S rRNA of mouse cecal contents on Mi Seq platform to understand the effect of taking fresh G. elata. As the results showing,multiple probiotics grew after taking fresh G. elata extract,including Ruminiclostridium,Butyricicoccus,and Parvibacter. To contrast,some pathogens or potential pathogens,such as Escherichia/Shigella,Parasutterella,decreased. This manifests that fresh G. elata performs a positive regulation on mouse gut microbiota,especially the low-dose fresh G. elata extraction could restructure the microbiota apparently. Our result reveals that microbiota might be a new target for G. elata extract and provides an important basis for further research on the interaction between gut microbiota and pharmacological activity of G. elata.
Animals
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Drugs, Chinese Herbal
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pharmacology
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Gastrodia
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chemistry
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Gastrointestinal Microbiome
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drug effects
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Medicine, Chinese Traditional
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Mice
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Plant Extracts
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pharmacology
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Plants, Medicinal
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chemistry
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RNA, Ribosomal, 16S
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genetics
9. Contemporary epidemiology and treatment of hospitalized heart failure patients in real clinical practice in China
Hua WANG ; Yingying LI ; Ke CHAI ; Wei ZHANG ; Xinli LI ; Yugang DONG ; Jingmin ZHOU ; Yong HUO ; Jiefu YANG
Chinese Journal of Cardiology 2019;47(11):865-874
Objective:
To observe the etiology, comorbidities, clinical features and treatment patterns of hospitalized patients with heart failure (HF) in China.
Methods:
Data were collected prospectively on hospitalized patients with HF who were enrolled in China Heart Failure Center Registry Study from 169 participating hospitals from January 2017 to August 2018. In this cross-sectional study, patients were stratified by left ventricular ejection fraction (LVEF) category: heart failure with reduced ejection fraction (HFrEF, LVEF
10. Effects of micronutrients supplementation on plasma homocysteine level and global cognitive function among older adults in long-term care facilities: a randomized controlled study
Qian REN ; Hua XIE ; Yanqiu CHEN ; Caifang WU ; Huo LI ; Jing LIU ; Xun LI ; Na LIN ; Wei YUAN ; Yunhua YANG ; Hangmei JIN ; Jianqin SUN
Chinese Journal of Clinical Nutrition 2019;27(5):265-270
Objective:
To investigate the effects of micronutrient supplementation for the elderly on plasma homocysteine level and cognitive function in institutional older adults.
Methods:
A total of 98 older adults with the score≤11 by mini nutritional assessment short-form aged 65-100 years were enrolled and assigned to either intervention group or control group (


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