Objective To explore the relationship between the oral health status with the severity and outcome of pediatric bronchopneumonia.Methods A total of 150 children patients with bronchopneumonia admitted and treated in this hospital from January 2020 to August 2022 were selected as the observation group(n=150).According to the severity of the illness,the children patients were divided into the mild group(n=97)and severe group(n=53).In addition,150 children undergoing physical examination during the same pe-riod were selected as the control group(n=150).The changes in the decay missing filling surface(DMFS),simplified oral hygiene index(OHI-s)and plaque index(PLI)were analyzed.Spearman was used to analyze the relationship between the oral health status and the severity of bronchopneumonia.After one month of treatment,the changes in oral health status were analyzed under different outcome conditions.The receiver op-erating characteristic(ROC)curve was drawn to assess the predictive effect of the oral health status on the outcome of pediatric bronchopneumonia.Results The DMFS,OHI-s scores and PLI scores in the observation group were higher than those in the control group(P＜0.05).The DMFS,OHI-s score and PLIscores in the severe group were higher than those in the mild group(P＜0.05).Spearman analysis found that DMFS,OHI-s and PLI were positively correlated with the severity(r=0.441,0.253,0.328,P＜0.05).The levels of DMFS,OHI-s and PLI in the poor prognosis group were higher than those in the good prognosis group(P＜0.05).The area under the curve(AUC)of DMFS,OHI-s and PLI combination in predicting the outcome of bronchopneumonia was 0.851(0.703～0.999),with a sensitivity of 83.78％and a specificity of 92.92％.Con-clusion The oral health status is closely related to the severity of pediatric bronchopneumonia,which can be used to assess the outcome of the children patients.

Objective To explore the clinical significance of immunocyte subsets before and after immunosuppressive therapy in the peripheral blood of patients with immune thrombocytopenic purpura (ITP).MethodsThe percentages of immunocyte subsets in the peripheral blood of 35 patients with ITP and 20 healthy controls were detected by flow cytometry,including CD3+,CD4+,CD8+,CD56+,CD19+ lymphocytes and CD4+/CD8+.Results The percentages of CD3+ T lymphocyte (61.58 ± 6.45 ) %,CD4+ T lymphocyte (28.38 ±4.89)% and the ratio of CD4+/CD8+ 0.99 0.22 in patients with ITP were lower than those in healthy controls[( 67.85 ± 4.68 ) %,( 38.00 ± 3.37 ) %,1.54 ± 0.13,all P ＜ 0.05].After immunosuppressive therapy,the percentages of CD3+ T lymphocyte ( 69.41 ± 5.03 ) %,CD4+ T lymphocyte (38.17 ±3.18)% and the ratio of CD4+/CD8+ 1.60 ±0.15 recovered to control levels.The percentages of CD8+ T lymphocyte (29.20 ±4.50)% and CD19+B lymphocyte ( 17.74 ±4.14)% were higher than those in healthy controls[( 24.82 ± 2.93 ) % and ( 12.09 ± 3.51 ) %,all P ＜ 0.05].After the immunosuppressive therapy,the percentages of CD8+ T lymphocyte ( 24.06 ± 3.02 ) % and CD19+ B lymphocyte ( 10.90 ± 3.55 ) %recovered to control levels.There were no significant difference of the percentage of CD56+ lymphocyte among ITP patients ( 15.80 ± 2.85 )%,ITP patients after immunosuppressive therapy ( 15.16 ± 2.77 )% and healthy controls ( 16.36 ± 2.75 ) %.ConclusionThe aberrant immunocyte subsets are involved in the pathogenesis of ITP,and detection of immunocyte subsets might be helpful for the diagnosis and determination of therapeutic outcome of ITP.

AIM: To study the effect of Qingqi Liangying Injection on febrile rats induced by zymonsa and on content of PGE_2 as well as cAMP in rat hypothalamus. METHODS: The rat febrific model induced by 10% zymonsa solution was used to observe QingqiLiangying Injection's effect on the rat temperature, and the radioimmunoassay(RIA) was used to determin the content of PGE_2 and cAMP in hypothalamus of rats. RESULTS: Qingqi Liangying Injection had an obvious antipyretic effect on febrile rats; Qingqi Liangying Injection could significantly reduce the content of PGE_2 and cAMP. CONCLUSION: Qingqi Liangying Injection can obviously reduce the rat body temperature and the content of PGE_2 and cAMP in hypothalamus of rats.