Hearing loss is the most prevalent disabling disease. Cochlear implantation（CI） serves as the primary intervention for severe to profound hearing loss. This consensus systematically explores the value of genetic diagnosis in the pre-operative assessment and efficacy prognosis for CI. Drawing upon domestic and international research and clinical experience, it proposes an evidence-based medicine three-tiered prognostic classification system（Favorable, Marginal, Poor）. The consensus focuses on common hereditary non-syndromic hearing loss（such as that caused by mutations in genes like GJB2, SLC26A4, OTOF, LOXHD1） and syndromic hereditary hearing loss（such as Jervell & Lange-Nielsen syndrome and Waardenburg syndrome）, which are closely associated with congenital hearing loss, analyzing the impact of their pathological mechanisms on CI outcomes. The consensus provides recommendations based on multiple round of expert discussion and voting. It emphasizes that genetic diagnosis can optimize patient selection, predict prognosis, guide post-operative rehabilitation, offer stratified management strategies for patients with different genotypes, and advance the application of precision medicine in the field of CI.
Humans ; Cochlear Implantation ; Prognosis ; Hearing Loss/surgery* ; Consensus ; Connexin 26 ; Mutation ; Sulfate Transporters ; Connexins/genetics*

Objective:To explore the multiple mediation effects of the positive and negative affect between emotional intelligence and life satisfaction in military personnel.Methods:Totally 967 male military personnel aged 17 to 34 years were investigated with the Schutte's Emotional Intelligence Scale (SSEIS),the Positive Affect and Negative Affect Scale (PANAS) and Life Satisfaction Index A (LSIA).The relationship among these variables was analyzed by using path analysis and Bootstrap test.Results:Totally 68.7％ military personnel were satisfied with their lives.Path analysis showed that emotional intelligence had indirect effects on life satisfaction through the mediation effects of positive affect and negative affect (x2/df=8.88,GFI =0.98,AGFI =0.94,NFI =0.98,IFI =0.98,TLI =0.95,CFI =0.98,RMSEA =0.09).Bootstrap test showed that the mediational path through positive affect and negative affect with the effect size were 31.5％ and 14.8％,and the total mediational effect size was 46.3％.Conclusion:It suggests that positive affect and negative affect may have mediating effects on the relationship between emotional intelligence and life satisfaction among military personnel.

Objective To evaluate the application value of serum tumor markers in small cell lung Cancer, and analyse the relationship between serum tumor markers and immunohistochemistry indicators.Methods The electrochemical luminescence technology was used to detect the concentration of carcino-embryonic anti-gen(CEA),neuronspecific enolase(NSE),cyto-keratin fragment 19(CYFRA21-1),the immunological lumines-cence technology was used to detect the concentration of ProGRP,the expression of Ki-67,TTF-1 were detec-ted by MaxVision immunohistochemistry methods,the date was analyzed by two independent sample rank sum test,rank correlation methods,chi-square test and ROC curve.Results The concentration of CEA,NSE,pro-gastrin-releasing peptide(ProGRP),CYFRA21-1 in SCLC were higher than that in benign disease,the concen-tration of CEA,NSE,ProGRP,CYFRA21-1 in extensive stage were higher than that in limited stage(P<0. 05),the difference was statistically significant.The ROC area of NSE,ProGRP were large,they were 0.972 and 0.965,the Kappa value of the NSE+ProGRP was 0.860,optimstic data consistency with "the gold stand-ard".There was a negative relationship between Ki-67 and CEA,NSE,ProGRP,the positive rate of TTF-1 was higher than CYFRA21-1,while lower than ProGRP,But NSE,CEA and TTF-1 have same results(P>0.05). Conclusion Combined detection NSE and ProGRP is of great value in the diagnosis and periods of SCLC,the sensibility and specificity of NSE+ProGRP was high in SCLC,he high expression of Ki-67 was not responsed the concentration of serum tumor markers,TTF-1 had the same results with NSE,while inferior to ProGRP in detect of SCLC.

Objective To explore the mediation effect of adult attachment on the relationship between childhood trauma and borderline personality disorder(BPD) in recruits.Methods Childhood trauma questionnaire-28 short form (CTQ-SF),adult attachment scale (AAS) and personality diagnostic questionnaire-4+ (PDQ-4+) were administered to 1 750 recruits in the autumn of 2013.Results The scores of physical neglect,emotional neglect,emotional abuse,sexual abuse,physical abuse,attachment anxiety,attachment close and dependence and BPD were 11.05±3.04,10.00±3.54,6.73±2.32,5.92±2.06,5.83± 1.97,3.02 ± ±0.53,3.19±0.44,2.45± 2.04,respectively.BPD had significantly positive correlation with childhood trauma and attachment anxiety (r=0.353,0.284,P＜ 0.01),and significantly negative correlation with attachment close and dependence(r=-0.198,P＜0.01).Childhood trauma,attachment close and dependence and attachment anxiety could positively predict BPD(F=142.172,P＜0.01),which could explain 19.6％ of the total variation.Structure equation model and Bootstrap test showed that childhood trauma not only directly predict BPD in recruits,but also indirectly predict BPD in recruit through attachment close and dependence and attachment anxiety (x2/df=11.472,RMSEA =0.077,NFI =0.943,RFI =0.901,IFI =0.948,TLI =0.902,CFI =0.948),and the mediational path through attachment close and dependence and attachment anxiety with the effect size were 10.8％ and 8.1％,and the total mediational effect size was 18.9％.Conclusion Adult attachment exerts a multiple mediation effect on the relationship between childhood abuse and BPD in recruits.

Objective To explore sleep quality and related psychological factors among young army cadres to provide theoretical basis for health interventions. Method A total of 1 100 young army cadres aged 18 to 34 were assessed with Pittsburgh sleep quality index (PSQI), Symptom Checklist-90 (SCL-90) and Center for Epidemiologic Studies Depression Scale by cluster random sampling. Based on CES-C scores, cadres were divided into two groups named depression group and non-depression group;850 sergeants were served as the control group. T test, chi-square test and multiple regressions were used in data analysis. Result Sleep problems were found in 13.5% of the cadres and 12.1% sergeants. General status of sleep quality of cadres was worse than sergeants' and norm's. Exercise less, physical disease and psychological problems were the risk factors. Multiple stepwise regression analysis showed that depression factors of SCL-90 had the most significantly predictive effect on sleep quality (r=0.552, Beta=0.387), followed by somatization (r=0.552, Beta=0.223), two factors could explain 32.7% of PSQI scores variation. Correlation analysis showed that depression is closely related to subjective sleep quality, sleep duration, sleep disorder and daytime dysfunction (all r>0.3). Cadres' depression (11.11 ± 6.62) was significantly lower than norm's (12.30 ± 10.39) and higher than sergeants'(8.11 ± 6.56). PSQI scores of depression group (6.05 ± 3.13) were significantly higher than non-depression group's (3.56 ± 2.69) and norm's (3.23 ± 3.12). Conclusion Depression is a major correlation factor of the sleep quality. Regular exercise, improvement of the physical and psychological health quality, and reducing depression are effective ways to improve sleep quality.

Objective To explore the relationship between personality and depression,especially to investigate mediating effect of positive mental characters.Methods A sample of 1 933 male recruits was assessed with eysenck personality questionnaire (EPQ),positive mental characters scale for recruits (PMCS-R) and self-rating depression scale (SDS).Results The scores of introversion-extroversion,psychoticism,neuroticism,positive mental characters and depression were 55.26±10.59,42.85±7.25,42.35± 11.67,3.80±0.64,0.45±0.11,respectively.There were correlations among personality,positive mental characters and depression in recruits (P＜0.05).Regression analysis indicated that introversion-extroversion,psychoticism and neuroticism predicted depression directly,and it could explain 42.6％ of the total variance (F=476.28,P＜0.05).Hierarchy regression analysis showed that positive mental characters mediate the relationship between personality (introversion-extroversion,psychoticism,neuroticism) and depression (the mediation effect was 0.22,0.19 and 0.11 respectively,P＜ 0.05).Conclusion Recruits' personality affects depression not only directly,but also indirectly through positive mental characters.

Objective To explore the mediating effect and moderating effect of positive mental characters in the relationship between childhood abuse and depression among recruits.Methods 1925 recruits aged from 16 ～24 were investigated using the Childhood Trauma Questionnaire-28 item Short Form (CTQ-SF),Self-Rating Depression Scale (SDS) and Positive Mental Characters Scale for Recruits (PMCS-R) through random cluster sampling.Results The scores of emotional abuse,physical abuse,sex abuse,emotional neglect,physical neglect,depression,positive mental characters were 6.11±1.69,5.49±1.32,5.61±1.45,9.15±3.66,9.57±2.93,0.45±0.11,3.80±0.64,respectively.There were correlations among childhood abuse,depression and positive mental characters (P＜0.05).Emotional neglect,physical neglect and emotional abuse could explain 28.6％ of the total variance of depression (F=256.72,P＜0.05).The positive mental characters partially mediated the relationship between emotional neglect,physical neglect,emotional abuse and depression (mediating effect were 0.19,0.15 and 0.09,respectively),and it could only moderate the relationship between emotional neglect and depression (F=24.73,P＜0.05).Conclusion Childhood abuse not only directly but also indirectly affects depression through the positive mental characters;meanwhile the positive mental characters can change the relationship between childhood abuse and depression.

Objective To examine the impact of stressful training on recruits and relationships with adult attachment,neuroticism and negative coping style.Methods 1 962 recruits were assessed with aduh attachment scale (AAS),impact of event scale-revised (IES-R),Eysenck personality questionnaire (EPQ) and trait coping style questionnaire (TCSQ).Results (1) 67.84％ of recruits reported the varying degrees of stress,and the total average of IES-R was 1.25±0.53.The impact of training of only-child recruits (1.28±0.56) was higher than that of none-only-child (1.22±0.51) (P＜0.05).The total average of attachment close was 3.73±0.51,attachment depend was 3.24±0.53,and attachment anxiety was 2.40±0.77.(2) Attachment anxiety,neuroticism and negative coping style were all positively correlated with impact of training (r =0.384,0.570,0.543,all P＜ 0.01).Attachment close and depend were both negatively correlated with impact of training (r=-0.221,-0.251,all P＜ 0.01).(3) Neuroticism and negative coping style played a completely intermediary role between adult attachment and impact of training.(4) The multiple group analysis showed that the mediation model was adapted to the only-child or none-onlychild recruits.Conclusion Adult attachment can predict impact of training to some extent in the intermediary roles of neuroticism and negative coping style.

OBJECTIVETo study the steroidal alkaloids in Veratrum dahuricum.

METHODThe compounds were isolated and purified by various column chromatographic methods. Their structures were identified by spectroscopic analysis.

RESULTFive compounds were isolated and identified as (20R, 22S, 25S)-veratra-5,13-dien-3beta-ol (1), angeloylzygadenine (2), 15-O-(2-methylbutanoyl)-3-O-veatroylprotoverine (3), 20-isoveratramine (4), veratramine (5).

CONCLUSIONCompound 1 was a new compound, compounds 24 were obtained from the plant for the first time.

OBJECTIVETo study the components in aerial part of Siegesbeckia pubescens.

METHODThe compounds were isolated and purified by silica gel, sephadex LH-20 and other column chromatography. Structures were elucidated by spectroscopic methods.

RESULTFour compounds were isolated from S. pubescens and were characterized as dimethyl-21-ethenetylene-darutigenol-3-O-beta-D-glucopyranosid (1), darutigenol (2), darutoside (3), stigmaster-3-O-beta-D-glucopyranosid (4).

CONCLUSIONCompound 1 is a new compound.