Objective:To investigate the safety and efficacy of Fuzheng Kangfu (FK) formula combined with chemotherapy in the treatment of pancreatic cancer.Methods:A retrospective analysis was conducted on 95 pancreatic cancer patients who received conventional chemotherapy between June 2021 and June 2024. The patients were divided into the integrated traditional Chinese medicine treatment group (treatment group) and the chemotherapy-only group (control group) according to whether receiving FK formula during chemotherapy. Baseline characteristics, clinical indicators before and after treatment, incidence of adverse reactions, and overall survival were compared between the two groups.Results:After propensity score matching, 39 patients were included in each group. Compared with the control group, the treatment group presented significantly higher globulin levels [28.60 (24.70, 32.15) g/L vs 24.90 (22.40, 29.95) g/L], alongside lower levels of D-dimer [1 200 (720, 1 690) μg/L vs 2 230 (1 040, 3 330) μg/L], creatinine (64.29±15.97 μmol/L vs 77.71±12.26 μmol/L), urea nitrogen [3.43(2.58, 4.67) mmol/L vs 4.87 (3.80, 6.24) mmol/L], and fasting blood glucose [4.68(3.95, 5.73) mmol/L vs 6.91 (5.27, 7.70) mmol/L]. Furthermore, the treatment group exhibited significantly greater decreases in C-reactive protein (CRP), alanine aminotransferase (ALT), aspartate aminotransferase (AST), indirect bilirubin, D-dimer, fibrinogen, and urea nitrogen levels compared to the control group. Conversely, the decreases of hemoglobin level and body mass index in the control group were more pronounced than that of the treatment group. The incidence of chemotherapy-related adverse reactions such as leukopenia (7.7% vs 33.3%), anemia (15.4% vs 35.9%), liver dysfunction (28.2% vs 53.8%), gastrointestinal reactions (5.1% vs 20.5%), and neurotoxicity (0.0% vs 15.4%) in the treatment group was notably lower than that in the control group. The treatment group showed prolonged median survival (14 month vs 9 month). The 1, 1.5 and 2-year survival rates of the treatment group were higher than the control group (56.76% vs 42.95%, 35.77% vs 32.72% and 23.85% vs 19.63%). All aforementioned differences were statistically significant (all P value <0.05). Conclusions:The integration of the FK formula with chemotherapy in the management of pancreatic cancer could effectively mitigate clinical manifestations, enhance quality of life, extend survival duration, and diminish chemotherapy-induced adverse effects.

Objective:To investigate the safety and efficacy of Fuzheng Kangfu (FK) formula combined with chemotherapy in the treatment of pancreatic cancer.Methods:A retrospective analysis was conducted on 95 pancreatic cancer patients who received conventional chemotherapy between June 2021 and June 2024. The patients were divided into the integrated traditional Chinese medicine treatment group (treatment group) and the chemotherapy-only group (control group) according to whether receiving FK formula during chemotherapy. Baseline characteristics, clinical indicators before and after treatment, incidence of adverse reactions, and overall survival were compared between the two groups.Results:After propensity score matching, 39 patients were included in each group. Compared with the control group, the treatment group presented significantly higher globulin levels [28.60 (24.70, 32.15) g/L vs 24.90 (22.40, 29.95) g/L], alongside lower levels of D-dimer [1 200 (720, 1 690) μg/L vs 2 230 (1 040, 3 330) μg/L], creatinine (64.29±15.97 μmol/L vs 77.71±12.26 μmol/L), urea nitrogen [3.43(2.58, 4.67) mmol/L vs 4.87 (3.80, 6.24) mmol/L], and fasting blood glucose [4.68(3.95, 5.73) mmol/L vs 6.91 (5.27, 7.70) mmol/L]. Furthermore, the treatment group exhibited significantly greater decreases in C-reactive protein (CRP), alanine aminotransferase (ALT), aspartate aminotransferase (AST), indirect bilirubin, D-dimer, fibrinogen, and urea nitrogen levels compared to the control group. Conversely, the decreases of hemoglobin level and body mass index in the control group were more pronounced than that of the treatment group. The incidence of chemotherapy-related adverse reactions such as leukopenia (7.7% vs 33.3%), anemia (15.4% vs 35.9%), liver dysfunction (28.2% vs 53.8%), gastrointestinal reactions (5.1% vs 20.5%), and neurotoxicity (0.0% vs 15.4%) in the treatment group was notably lower than that in the control group. The treatment group showed prolonged median survival (14 month vs 9 month). The 1, 1.5 and 2-year survival rates of the treatment group were higher than the control group (56.76% vs 42.95%, 35.77% vs 32.72% and 23.85% vs 19.63%). All aforementioned differences were statistically significant (all P value <0.05). Conclusions:The integration of the FK formula with chemotherapy in the management of pancreatic cancer could effectively mitigate clinical manifestations, enhance quality of life, extend survival duration, and diminish chemotherapy-induced adverse effects.

During "Mission Harmony 2018", the crew on the hospital ship were prone to various physiological and psychological reactions that affected their health. Based on the characteristics of the Mission, our own work experience on board, and the requirements for mental health support during the Mission, we summarized and reflected on our mental health support for the crew and the mental health service for the local people of the host countries. We believe that it is vital to support the mental health of the crew during a long oceangoing mission by formulating and carrying out psychological interventions and training according to the on-board environment and different legs of the voyage. We hope that this paper can provide a reference for the mental health service in future long oceangoing missions.

During "Mission Harmony 2018", the crew on the hospital ship were prone to various physiological and psychological reactions that affected their health. Based on the characteristics of the Mission, our own work experience on board, and the requirements for mental health support during the Mission, we summarized and reflected on our mental health support for the crew and the mental health service for the local people of the host countries. We believe that it is vital to support the mental health of the crew during a long oceangoing mission by formulating and carrying out psychological interventions and training according to the on-board environment and different legs of the voyage. We hope that this paper can provide a reference for the mental health service in future long oceangoing missions.

Objective:To study the changes of the crew’s cognitive function and performance during long oceangoing voyages.Methods:The cognitive function and performance of the crew members of the " Mission Harmony 2018" were measured by the attention distribution instrument (EP708A), finger dexterity tester (EP109), and trail making test A and B at 1 month and 6 months after the Mission began, and the data were compared.Results:Comparing the data at 6 month after the Mission began with those at 1 month after the Mission began, the correct responses of the crew to the low-, middle-, and high-pitch sound were significantly increased ( P<0.01); the reaction time to middle-pitch sound and light was significantly reduced ( P<0.05); the wrong responses to low-pitch sound were significantly reduced ( P<0.01); the completion time of trail marking test A was significantly reduced ( P<0.05), while that of test B was significantly increased ( P<0.05); the time to finish finger dexterity task was significantly reduced ( P<0.01). Conclusion:The crew members had better cognitive function and performance in the late leg of the voyage than those in the early leg of the voyage.

During these missions, long-time maritime operations impose physical and psychological challenges to the officers and sailors, leading to more mental illness. At present, there is no systematic mental health work plan aimed at those problems of the officers and sailors on long oceangoing missions. Therefore, based on the experience and lessons gained from previous long oceangoing missions and the specific psychological status of the crew at different legs of long oceangoing missions, this paper elaborated the self-capability preparation of mental health providers, summarized the organization and implementation of mental health service throughout the whole mission, and presented a preliminary working outline of mental health service for the officers and sailors on long oceangoing missions, so as to guide the mental health providers to carry out their work effectively, thus improving the mental health of the officers and sailors on long oceangoing missions.

Objective:To study the changes of the crew’s cognitive function and performance during long oceangoing voyages.Methods:The cognitive function and performance of the crew members of the " Mission Harmony 2018" were measured by the attention distribution instrument (EP708A), finger dexterity tester (EP109), and trail making test A and B at 1 month and 6 months after the Mission began, and the data were compared.Results:Comparing the data at 6 month after the Mission began with those at 1 month after the Mission began, the correct responses of the crew to the low-, middle-, and high-pitch sound were significantly increased ( P<0.01); the reaction time to middle-pitch sound and light was significantly reduced ( P<0.05); the wrong responses to low-pitch sound were significantly reduced ( P<0.01); the completion time of trail marking test A was significantly reduced ( P<0.05), while that of test B was significantly increased ( P<0.05); the time to finish finger dexterity task was significantly reduced ( P<0.01). Conclusion:The crew members had better cognitive function and performance in the late leg of the voyage than those in the early leg of the voyage.

During these missions, long-time maritime operations impose physical and psychological challenges to the officers and sailors, leading to more mental illness. At present, there is no systematic mental health work plan aimed at those problems of the officers and sailors on long oceangoing missions. Therefore, based on the experience and lessons gained from previous long oceangoing missions and the specific psychological status of the crew at different legs of long oceangoing missions, this paper elaborated the self-capability preparation of mental health providers, summarized the organization and implementation of mental health service throughout the whole mission, and presented a preliminary working outline of mental health service for the officers and sailors on long oceangoing missions, so as to guide the mental health providers to carry out their work effectively, thus improving the mental health of the officers and sailors on long oceangoing missions.

According to the course teaching requirements of psychiatry,a serial teaching cases of case-based learning (CBL) is built based on cases from psychology department to assist in the theory teaching of Psychiatry.During the teaching process,the scenes where patients came to the psychology department were simulated and the information about the cases was provided step by step.For each step,students would be asked to discuss a series of questions regarding the cases in different groups.Along with CBL,students could thoroughly learn the main points of diagnosis and principles of treatment for common psychiatric disorders.The teaching effect showed that students' involvement in CBL courses,the interests in learning,self-study ability,independent thinking ability,capacity for self-expression,ability of creative thinking and comprehensive analysis and problem solving ability.were greatly improved.Most students were interested in CBL and it produced fruitful teaching results.

[Objective] To observe the effect of computer-aided detection (CAD) system in improving lung nodule detection sensitivity and inter-observer variation.[Methods] 300 PA digital radiographs including 100 normal cases and 200 cases with pulmonary nodules confirmed by CT were enrolled.Two senior chest radiologists referenced CT images and marked the sizes and locations of all nodules with consensus as the gold standards.Four senior radiologists and four junior radiologists interpreted the digital chest radiographs independently without and with CADand recordtheir results.Pair t test and coefficient of variation (CV) was used to compare the difference of lung nodule detection sensitivity and inter-observer variation between withoutand with CAD.[Results] The mean lung nodule detection sensitivity of senior and junior radiologists withoutand with CAD were (41.1 ± 2.0)％,(28.0 ± 2.0)％ and (45.0 ± 1.8)％,(39.2 ± 0.9)％,respectively,statistical analysis showed there was statistically significant difference.Moreover,CV of all radiologists without and with CAD were 20.9％ and 8.1％.[Conclusion] Both lung nodule detection sensitivity and inter-observer variation of senior and junior radiologists can be improved by CAD.