Objective To explore the association between single nucleotide polymorphism(SNP)of Rab37 gene and the age at menarche(AAM).Methods A case-control study design was used to conduct an epidemiologic survey on 2 060 women in a community in Jurong City,Jiangsu Province,and their venous blood samples were collected.ASA chip was used to explore the Rab37 gene genotyping of blood sample DNA to obtain the genotyping results for Rab37 SNPs rs62084865,rs10512597,rs35489971,rs1037170,rs6501732,rs77822106,and rs3178300.Based on menarche time of＜16 years old or≥16 years old,the participants were divided into 2 groups.Linear and logistic regression analyses were used to explore the association between the SNP of Rab37 gene and the age at menarche based on dominant,recessive and allelic models.Results Among the 2 060 healthy women,944 women had normal menstrual periods,while 1 116 women experienced delayed menarche.Linear regression analysis showed that the gene polymorphism of rs3178300 was negatively correlated with the age at menarche in females[recessive model:CC/CT+TT,β=-0.915,95%CI(-1.692,-0.137),P=0.021;allelic model:T/C,β=-0.221,95%CI(-0.410,-0.032),P=0.022].Logistic regression analysis indicated that the gene polymorphism of rs3178300 was significantly associated with the risk of delayed menarche in females[recessive model:CC/CT+TT,OR=0.295,95%CI(0.116,0.751),P=0.010;allelic model:T/C,OR=0.796,95%CI(0.652,0.972),P=0.025].The remaining 6 SNPs showed no significant association with age at menarche.Conclusion The rs3178300 polymorphism of Rab37 gene is significantly associated with delayed menarche in Chinese women.

More and more attention is being paid by all parties to the use of pricing and investment for achievement transforma-tion.It is of great significance to enhance the technological transformation ability and economic operation and management ability of public hospitals.Beijing,Shanghai,and Shenzhen have explored the introduction of local special policies to support local public hos-pitals in converting results through priced investment.However,compared with the mature support policies of relevant national regula-tory departments for universities,the improvement are still needed.It compared the pricing and investment policies of universities and relevant local public hospitals from key aspects and contents such as decision-making power of pricing and investment,share-holding platform requirements,completion reward standards,and tax preferential policies,and analyzed the shortcomings of pricing and investment policies in public hospitals.Then it proposed some suggestions,such as exploring innovative models of achievement transformation and shareholding platforms which suitable for public hospitals,further clarifying the content of decision-making exemp-tion policies and asset loss handling procedures.It puts forward countermeasures and suggestions to better promote the transformation of scientific and technological achievements in public hospitals.

More and more attention is being paid by all parties to the use of pricing and investment for achievement transforma-tion.It is of great significance to enhance the technological transformation ability and economic operation and management ability of public hospitals.Beijing,Shanghai,and Shenzhen have explored the introduction of local special policies to support local public hos-pitals in converting results through priced investment.However,compared with the mature support policies of relevant national regula-tory departments for universities,the improvement are still needed.It compared the pricing and investment policies of universities and relevant local public hospitals from key aspects and contents such as decision-making power of pricing and investment,share-holding platform requirements,completion reward standards,and tax preferential policies,and analyzed the shortcomings of pricing and investment policies in public hospitals.Then it proposed some suggestions,such as exploring innovative models of achievement transformation and shareholding platforms which suitable for public hospitals,further clarifying the content of decision-making exemp-tion policies and asset loss handling procedures.It puts forward countermeasures and suggestions to better promote the transformation of scientific and technological achievements in public hospitals.

More and more attention is being paid by all parties to the use of pricing and investment for achievement transforma-tion.It is of great significance to enhance the technological transformation ability and economic operation and management ability of public hospitals.Beijing,Shanghai,and Shenzhen have explored the introduction of local special policies to support local public hos-pitals in converting results through priced investment.However,compared with the mature support policies of relevant national regula-tory departments for universities,the improvement are still needed.It compared the pricing and investment policies of universities and relevant local public hospitals from key aspects and contents such as decision-making power of pricing and investment,share-holding platform requirements,completion reward standards,and tax preferential policies,and analyzed the shortcomings of pricing and investment policies in public hospitals.Then it proposed some suggestions,such as exploring innovative models of achievement transformation and shareholding platforms which suitable for public hospitals,further clarifying the content of decision-making exemp-tion policies and asset loss handling procedures.It puts forward countermeasures and suggestions to better promote the transformation of scientific and technological achievements in public hospitals.

More and more attention is being paid by all parties to the use of pricing and investment for achievement transforma-tion.It is of great significance to enhance the technological transformation ability and economic operation and management ability of public hospitals.Beijing,Shanghai,and Shenzhen have explored the introduction of local special policies to support local public hos-pitals in converting results through priced investment.However,compared with the mature support policies of relevant national regula-tory departments for universities,the improvement are still needed.It compared the pricing and investment policies of universities and relevant local public hospitals from key aspects and contents such as decision-making power of pricing and investment,share-holding platform requirements,completion reward standards,and tax preferential policies,and analyzed the shortcomings of pricing and investment policies in public hospitals.Then it proposed some suggestions,such as exploring innovative models of achievement transformation and shareholding platforms which suitable for public hospitals,further clarifying the content of decision-making exemp-tion policies and asset loss handling procedures.It puts forward countermeasures and suggestions to better promote the transformation of scientific and technological achievements in public hospitals.

More and more attention is being paid by all parties to the use of pricing and investment for achievement transforma-tion.It is of great significance to enhance the technological transformation ability and economic operation and management ability of public hospitals.Beijing,Shanghai,and Shenzhen have explored the introduction of local special policies to support local public hos-pitals in converting results through priced investment.However,compared with the mature support policies of relevant national regula-tory departments for universities,the improvement are still needed.It compared the pricing and investment policies of universities and relevant local public hospitals from key aspects and contents such as decision-making power of pricing and investment,share-holding platform requirements,completion reward standards,and tax preferential policies,and analyzed the shortcomings of pricing and investment policies in public hospitals.Then it proposed some suggestions,such as exploring innovative models of achievement transformation and shareholding platforms which suitable for public hospitals,further clarifying the content of decision-making exemp-tion policies and asset loss handling procedures.It puts forward countermeasures and suggestions to better promote the transformation of scientific and technological achievements in public hospitals.

More and more attention is being paid by all parties to the use of pricing and investment for achievement transforma-tion.It is of great significance to enhance the technological transformation ability and economic operation and management ability of public hospitals.Beijing,Shanghai,and Shenzhen have explored the introduction of local special policies to support local public hos-pitals in converting results through priced investment.However,compared with the mature support policies of relevant national regula-tory departments for universities,the improvement are still needed.It compared the pricing and investment policies of universities and relevant local public hospitals from key aspects and contents such as decision-making power of pricing and investment,share-holding platform requirements,completion reward standards,and tax preferential policies,and analyzed the shortcomings of pricing and investment policies in public hospitals.Then it proposed some suggestions,such as exploring innovative models of achievement transformation and shareholding platforms which suitable for public hospitals,further clarifying the content of decision-making exemp-tion policies and asset loss handling procedures.It puts forward countermeasures and suggestions to better promote the transformation of scientific and technological achievements in public hospitals.

More and more attention is being paid by all parties to the use of pricing and investment for achievement transforma-tion.It is of great significance to enhance the technological transformation ability and economic operation and management ability of public hospitals.Beijing,Shanghai,and Shenzhen have explored the introduction of local special policies to support local public hos-pitals in converting results through priced investment.However,compared with the mature support policies of relevant national regula-tory departments for universities,the improvement are still needed.It compared the pricing and investment policies of universities and relevant local public hospitals from key aspects and contents such as decision-making power of pricing and investment,share-holding platform requirements,completion reward standards,and tax preferential policies,and analyzed the shortcomings of pricing and investment policies in public hospitals.Then it proposed some suggestions,such as exploring innovative models of achievement transformation and shareholding platforms which suitable for public hospitals,further clarifying the content of decision-making exemp-tion policies and asset loss handling procedures.It puts forward countermeasures and suggestions to better promote the transformation of scientific and technological achievements in public hospitals.

More and more attention is being paid by all parties to the use of pricing and investment for achievement transforma-tion.It is of great significance to enhance the technological transformation ability and economic operation and management ability of public hospitals.Beijing,Shanghai,and Shenzhen have explored the introduction of local special policies to support local public hos-pitals in converting results through priced investment.However,compared with the mature support policies of relevant national regula-tory departments for universities,the improvement are still needed.It compared the pricing and investment policies of universities and relevant local public hospitals from key aspects and contents such as decision-making power of pricing and investment,share-holding platform requirements,completion reward standards,and tax preferential policies,and analyzed the shortcomings of pricing and investment policies in public hospitals.Then it proposed some suggestions,such as exploring innovative models of achievement transformation and shareholding platforms which suitable for public hospitals,further clarifying the content of decision-making exemp-tion policies and asset loss handling procedures.It puts forward countermeasures and suggestions to better promote the transformation of scientific and technological achievements in public hospitals.

Objective: This study’s objective is to assess the efficacy and safety of Pulsed Magnetic Therapy System (PMTS) in improving insomnia disorder. Methods: Participants with insomnia disorder were randomly assigned to receive either PMTS or sham treatment for four weeks (n= 153; PMTS: 76, sham: 77). Primary outcomes are the Insomnia Severity Index (ISI) scores at week 0 (baseline), 1, 2, 3, 4 (treatment), and 5 (follow-up). Secondary outcomes are the Pittsburgh Sleep Quality Index at baseline and week 4, and weekly sleep diary-derived values for sleep latency, sleep efficiency, real sleep time, waking after sleep onset, and sleep duration. Results: The ISI scores of the PMTS group and the sham group were 7.13±0.50, 11.07±0.51 at week 4, respectively. There was a significant group×time interaction for ISI (F3.214, 485.271=24.25, p<0.001, ηp 2=0.138). Only the PMTS group experienced continuous improvement throughout the study; in contrast, the sham group only experienced a modest improvement after the first week of therapy. At the end of the treatment and one week after it, the response of the PMTS group were 69.7% (95% confidence interval [CI]: 58.6%–79.0%), 75.0% (95% CI: 64.1%–83.4%), respectively, which were higher than the response of the sham group (p<0.001). For each of the secondary outcomes, similar group×time interactions were discovered. The effects of the treatment persisted for at least a week. Conclusion PMTS is safe and effective in improving insomnia disorders.