Objective To investigate the value of parameters of MR diffusion kurtosis imaging(DKI)for predicting human epidermal growth factor receptor 2(HER2)-positive breast cancer(BC).Methods A total of 122 cases of BC diagnosed by pathology were retrospectively enrolled,including 37 cases of HER2-positive(HER2-positive group)and 85 cases of HER2-negative(HER2-negative group).Parameters obtained based on MR DKI(mean diffusivity[MD]and mean kurtosis[MK]values)and the results of immunohistochemical detection(expression of matrix metalloproteinase-2[MMP-2],vascular endothelial growth factor receptor 2[VEGFR-2])were compared between groups.Then maltivariable logistic regression was used to analyze the independent predictors of HER2-positive BC based on DKI parameters being statistically different between groups,and a combined model was constructed.Receiver operating characteristic(ROC)curve was drawn,and the area under the curve(AUC)were calculated to assess the efficacy of each single DKI parameter and their combined model for predicting HER2-positive BC,and the correlations of these DKI parameters with MMP-2 or VEGFR-2 expressions were analyzed.Results Compared with HER2-negative group,MD value,MK value,positive expression proportion of MMP-2 and VEGFR-2 increased in HER2-positive group(all P＜0.05).Both MD(OR=1.423)and MK(OR=1.624)values were independent predictors of HER2-positive BC(both P＜0.05),with AUC for predicting HER2-positive BC of 0.819 and 0.836,respectively,while the AUC of combined model of MD and MK values was 0.916.MD value of BC was positively correlated with MMP-2(rs=0.222)and VEGFR-2 expression(rs=0.232)(both P＜0.05),while MK value of BC was not significantly correlated with MMP-2 or VEGFR-2 expression(both P＞0.05).Conclusion As parameters of MR DKI,MD and MK values could be used to effectively predict HER2-positive BC.

Objective To investigate the value of parameters of MR diffusion kurtosis imaging(DKI)for predicting human epidermal growth factor receptor 2(HER2)-positive breast cancer(BC).Methods A total of 122 cases of BC diagnosed by pathology were retrospectively enrolled,including 37 cases of HER2-positive(HER2-positive group)and 85 cases of HER2-negative(HER2-negative group).Parameters obtained based on MR DKI(mean diffusivity[MD]and mean kurtosis[MK]values)and the results of immunohistochemical detection(expression of matrix metalloproteinase-2[MMP-2],vascular endothelial growth factor receptor 2[VEGFR-2])were compared between groups.Then maltivariable logistic regression was used to analyze the independent predictors of HER2-positive BC based on DKI parameters being statistically different between groups,and a combined model was constructed.Receiver operating characteristic(ROC)curve was drawn,and the area under the curve(AUC)were calculated to assess the efficacy of each single DKI parameter and their combined model for predicting HER2-positive BC,and the correlations of these DKI parameters with MMP-2 or VEGFR-2 expressions were analyzed.Results Compared with HER2-negative group,MD value,MK value,positive expression proportion of MMP-2 and VEGFR-2 increased in HER2-positive group(all P＜0.05).Both MD(OR=1.423)and MK(OR=1.624)values were independent predictors of HER2-positive BC(both P＜0.05),with AUC for predicting HER2-positive BC of 0.819 and 0.836,respectively,while the AUC of combined model of MD and MK values was 0.916.MD value of BC was positively correlated with MMP-2(rs=0.222)and VEGFR-2 expression(rs=0.232)(both P＜0.05),while MK value of BC was not significantly correlated with MMP-2 or VEGFR-2 expression(both P＞0.05).Conclusion As parameters of MR DKI,MD and MK values could be used to effectively predict HER2-positive BC.

Objective To explore the application value of emergency temporal body surface positioning for single drain dual-target thalamic hematoma ventricular drainage in the treatment of thalamic hemorrhage breaking into ventricle with hydrocephalus.Methods A retrospective analysis was conducted on 223 patients with thalamic hemorrhage breaking into the ventricles with hydrocephalus,including a study group of 115 cases who underwent emergency single drain dual-target thalamic hematoma ventricular drainage surgery with temporal body surface positioning,and a control group of 108 cases who underwent emergency ventricular drainage first and then underwent stereotactic thalamic hematoma drainage surgery after the condition stabilized.Compare the differences in postoperative complications and treatment outcomes between two groups of patients,and evaluate the application value of temporal surface positioning for single drain dual-target thalamic hematoma ventricular drainage surgery in the treatment of thalamic hemorrhage breaking into the ventricle with hydrocephalus.Results The postoperative rebleeding rates,hematoma clearance and death were 5.2％,87.5％±7.3％and 13.9％in the study group and 4.7％,90.2％±8.5％and 15.7％in control group,respectively.There was no significant difference between the two groups(P＞0.05).The tube time,postoperative intracranial infection,Shunt dependent hydrocephalus,effective treatment and favorable prognosis of and the control group were(75.5±18.4)h,3.5％,19.1％,53.9％and 51.3％in the study group and(130.8±22.9)h,13.9％,35.1％,38.7％and 38.0％,respectively.The difference between the two groups was statistically significant(P＜0.05).Conclusion Body surface landmark-guided emergency single drain dual-target thalamic hematoma ventricular drainage surgery for the treatment of thalamic hemorrhage breaking into the ventricle with hydrocephalus is safe and reliable,and can improve the patient's prognosis.