Objective:To evaluate the risk of endometrial cancer in patients treated with endocrine therapy after breast cancer surgery.Methods:Medical records of 117 patients with breast cancer treated in Ruijin Hospital, Shanghai Jiao Tong University School of Medicine from August 2012 to August 2023 were retrospectively analyzed. All patients were treated with endocrine therapy drugs after radical surgery for breast cancer. They were divided into cancer group and non-cancer group according to whether endometrial cancer occurred. The differences in age, menopause years, duration of endocrine therapy, uterine cavity occupation, and endometrial thickness between the two groups were compared. Multivariate logistic regression model was used to evaluate the risk of endometrial cancer in breast cancer patients undergoing postoperative endocrine therapy.Results:There were no significant differences in age, menopause years, endocrine treatment time, uterine cavity occupation ratio between cancer and non-cancer groups (all P>0.05). Endometrial thickness in the cancer group was significantly higher than that in the non-cancer group ( P<0.001). Multiple logistic regression analysis model showed that endometrial thickness was a risk factor for endometrial cancer ( P<0.05). The sensitivity, specificity, positive predictive value (71.4%) and negative predictive value (99.1%) were 83.3%, 98.2%, 71.4%, and 99.1% respectively, for predicting the risk of endometrial cancer in patients with postoperative endocrine therapy. Conclusions:The endometrial thickness of patients with endometrial cancer after breast cancer surgery using endocrine therapy is significantly increased, and the risk fraction of endometrial cancer in patients with endocrine therapy after breast cancer surgery can be used to predict the likelihood of endometrial cancer.

Objective:To evaluate the risk of endometrial cancer in patients treated with endocrine therapy after breast cancer surgery.Methods:Medical records of 117 patients with breast cancer treated in Ruijin Hospital, Shanghai Jiao Tong University School of Medicine from August 2012 to August 2023 were retrospectively analyzed. All patients were treated with endocrine therapy drugs after radical surgery for breast cancer. They were divided into cancer group and non-cancer group according to whether endometrial cancer occurred. The differences in age, menopause years, duration of endocrine therapy, uterine cavity occupation, and endometrial thickness between the two groups were compared. Multivariate logistic regression model was used to evaluate the risk of endometrial cancer in breast cancer patients undergoing postoperative endocrine therapy.Results:There were no significant differences in age, menopause years, endocrine treatment time, uterine cavity occupation ratio between cancer and non-cancer groups (all P>0.05). Endometrial thickness in the cancer group was significantly higher than that in the non-cancer group ( P<0.001). Multiple logistic regression analysis model showed that endometrial thickness was a risk factor for endometrial cancer ( P<0.05). The sensitivity, specificity, positive predictive value (71.4%) and negative predictive value (99.1%) were 83.3%, 98.2%, 71.4%, and 99.1% respectively, for predicting the risk of endometrial cancer in patients with postoperative endocrine therapy. Conclusions:The endometrial thickness of patients with endometrial cancer after breast cancer surgery using endocrine therapy is significantly increased, and the risk fraction of endometrial cancer in patients with endocrine therapy after breast cancer surgery can be used to predict the likelihood of endometrial cancer.