Objective:To investigate the anxiety status of patients with myocardial infarction after percutaneous coronary intervention (PCI) and analyze its risk factors.Methods:Using the convenient sampling method, a total of 149 patients with myocardial infarction after PCI who were treated in Lu'an People's Hospital from February 2018 to February 2022 were selected as the research objects. Hamilton Anxiety Rating Scale (HAMA) was used to investigate, and patients were divided into the anxiety group ( n=59) and the non-anxiety group ( n=90) according to HAMA score. Binomial logistic regression analysis was used to explore the risk factors of anxiety in patients with myocardial infarction after PCI. Results:Among 149 patients with myocardial infarction after PCI, the incidence of anxiety was 39.60% (59/149) . The results of binomial logistic regression analysis showed that female, living in rural areas, combined with hypertension, double-vessel or more vascular disease, ejection fraction less than or equal to 50% and payment method of self-pay/new rural cooperative medical system were independent risk factors for anxiety after PCI for myocardial infarction ( P<0.05) . Conclusions:The main risk factors for anxiety in patients with myocardial infarction after PCI included female, living in rural areas, combination with hypertension, double-vessel or more vascular disease, ejection fraction less than or equal to 50%, and payment method of self-pay/new rural cooperative medical system. Clinical nursing staff should focus on high-risk groups and take targeted intervention measures to reduce the risk of anxiety in patients with myocardial infarction after PCI.