Objective To explore the value of Vision Transformer(ViT)fusion network assisted multiparametric MRI for diagnosing intracranial large vessel stenosis/occlusion(LVSO).Methods Totally 221 cases of ischemic stroke(IS)were retrospectively enrolled as test set,while other 28 cases of IS were taken as validation set,and data of diffusion weighted imaging(DWI),3D pseudo-continuous arterial spin labeling(3D-pCASL)and CT angiography(CTA)were collected.Taken CTA as reference standard,the value of ViT fusion network based on DWI,3D-pCASL and their combination for diagnosing intracranial LVSO were observed.Results In test set,the area under the curve(AUC)of ViT fusion network based on DWI,3D-pCASL and their combination for diagnosing intracranial LVSO was 0.879,0.908 and 0.925,respectively,no significant difference was found between each two(all P＞0.05),but AUC of DWI+3D-pCASL was slightly higher than that of the other two.In validation set,the AUC of ViT fusion network based on DWI+3D-pCASL for diagnosing intracranial LVSO was 0.850.Conclusion The performance of ViT fusion network based on DWI combined with 3D-pCASL for diagnosing intracranial LVSO was better.

This paper reports a case of hepatoblastoma that is inclined to misdiagnosis and missed diagnosis. The patient, a 6-month-old male, was admitted to Dermatology Department of Children’s Hospital of Nanjing Medical University and Beijing Children’s Hospital successively, because of a erythema on the neck for 6 months and a mass in the neck for 3 months. Abdominal ultrasonography and CT indicated the possibility of hepatic hemangioma, but further examination of alpha fetoprote and other indicators suggested hepatic malignant tumor. Therefore, surgery was performed to remove the liver mass, and postoperative pathology revealed hepatoblastoma. Postoperative chemotherapy was combined, and follow-up was conducted six months after the end of chemotherapy, with no recurrence of the disease. This article summarized the diagnosis and treatment process of this case and combined with literature review to provide experience for clinicians in the diagnosis and treatment of relevant cases.

Objective:To sinicize the Obsessive and Compulsive Behaviors Scale of Mothers in Postpartum Period Regarding Baby Care (OCBS-MPPRBC) to test its reliability and validity, and to provide an evaluation tool for evaluating the degree of compulsive behaviors of postpartum mothers regarding baby care.Methods:Following the principles of Brislin translation, back translation and cross-cultural adaptation, the Chinese version of OCBS-MPPRBC was formed. A convenient sampling method was used to investigate 360 women in Mianyang Central Hospital from November 2023 to February 2024, and to test the reliability and validity of the Chinese version OCBS-MPPRBC. The critical ratio method and the total correlation analysis method were used for item analysis, the reliability test was based on Cronbach α coefficient and half-reliability method, and the content validity index, exploratory factor analysis, confirmatory factor analysis and aggregate validity were used for validity test. Results:A total of 352 women aged 21-41 (31.55 ± 3.17) years who met the exclusion criteria were included. The Chinese version of OCBS-MPPRBC contained 9 items, and 2 common factors were extracted by exploratory factor analysis, and the cumulative total variance contribution rate was 65.523%. The content validity index of the scale level was 0.89, the content validity index of each item level was 0.86-1.00, and the Cronbach α coefficient of the total scale was 0.844, and the half-folded reliability was 0.759. The results of confirmatory factor analysis showed that the fitting index of the Chinese version of the OCBS-MPPRBC model was better. Conclusions:The Chinese version of the OCBS-MPPRBC scale has good reliability and validity, and has good operability, which can be used to evaluate the degree of compulsive behavior of postpartum mothers about baby care in China.

Objective:To retrieve and summarize the evidence regarding the non-surgical treatment and management of patients with pelvic organ prolapse (POP) .Methods:According to the "6S" evidence pyramid model, clinical guidelines, expert consensus, systematic reviews, clinical decisions, and clinical best practices related to the non-surgical treatment and management of patients with POP were systematically searched in databases and websites such as UpToDate, National Institute for Health and Clinical Excellence, Australia Joanna Briggs Institute (JBI) Evidence-Based Health Care Center Database, Guidelines International Network, National Guideline Clearinghouse, PubMed, China National Knowledge Infrastructure. The search period was from the establishment of the database to January 31, 2024. Two investigators independently conducted literature quality assessment and extracted relevant information according to the Appraisal of Guidelines for Research and EvaluationⅡ and the Australia JBI Evidence-Based Health Care Center evaluation tools. The Australia JBI quality level of evidence and grade of recommendation (2014 version) were used for evidence integration and grading.Results:A total of 15 papers were finally included, including three clinical decisions, eight guidelines, two best practices, one expert consensus, and one systematic review. A total of 39 pieces of best evidence were summarized in nine areas of examination and assessment, treatment plan, lifestyle, expectant therapy, functional exercise, physical therapy, pessary, drug therapy, and follow-up observation.Conclusions:This study summarizes the best evidence on the non-surgical treatment and management of POP patients, which is scientific and comprehensive, and provides an evidence-based basis for medical and nursing staff to develop non-surgical treatment and management protocols for POP patients and self-management of POP patients.

Objective:To sinicize the Obsessive and Compulsive Behaviors Scale of Mothers in Postpartum Period Regarding Baby Care (OCBS-MPPRBC) to test its reliability and validity, and to provide an evaluation tool for evaluating the degree of compulsive behaviors of postpartum mothers regarding baby care.Methods:Following the principles of Brislin translation, back translation and cross-cultural adaptation, the Chinese version of OCBS-MPPRBC was formed. A convenient sampling method was used to investigate 360 women in Mianyang Central Hospital from November 2023 to February 2024, and to test the reliability and validity of the Chinese version OCBS-MPPRBC. The critical ratio method and the total correlation analysis method were used for item analysis, the reliability test was based on Cronbach α coefficient and half-reliability method, and the content validity index, exploratory factor analysis, confirmatory factor analysis and aggregate validity were used for validity test. Results:A total of 352 women aged 21-41 (31.55 ± 3.17) years who met the exclusion criteria were included. The Chinese version of OCBS-MPPRBC contained 9 items, and 2 common factors were extracted by exploratory factor analysis, and the cumulative total variance contribution rate was 65.523%. The content validity index of the scale level was 0.89, the content validity index of each item level was 0.86-1.00, and the Cronbach α coefficient of the total scale was 0.844, and the half-folded reliability was 0.759. The results of confirmatory factor analysis showed that the fitting index of the Chinese version of the OCBS-MPPRBC model was better. Conclusions:The Chinese version of the OCBS-MPPRBC scale has good reliability and validity, and has good operability, which can be used to evaluate the degree of compulsive behavior of postpartum mothers about baby care in China.

Objective:To retrieve and summarize the evidence regarding the non-surgical treatment and management of patients with pelvic organ prolapse (POP) .Methods:According to the "6S" evidence pyramid model, clinical guidelines, expert consensus, systematic reviews, clinical decisions, and clinical best practices related to the non-surgical treatment and management of patients with POP were systematically searched in databases and websites such as UpToDate, National Institute for Health and Clinical Excellence, Australia Joanna Briggs Institute (JBI) Evidence-Based Health Care Center Database, Guidelines International Network, National Guideline Clearinghouse, PubMed, China National Knowledge Infrastructure. The search period was from the establishment of the database to January 31, 2024. Two investigators independently conducted literature quality assessment and extracted relevant information according to the Appraisal of Guidelines for Research and EvaluationⅡ and the Australia JBI Evidence-Based Health Care Center evaluation tools. The Australia JBI quality level of evidence and grade of recommendation (2014 version) were used for evidence integration and grading.Results:A total of 15 papers were finally included, including three clinical decisions, eight guidelines, two best practices, one expert consensus, and one systematic review. A total of 39 pieces of best evidence were summarized in nine areas of examination and assessment, treatment plan, lifestyle, expectant therapy, functional exercise, physical therapy, pessary, drug therapy, and follow-up observation.Conclusions:This study summarizes the best evidence on the non-surgical treatment and management of POP patients, which is scientific and comprehensive, and provides an evidence-based basis for medical and nursing staff to develop non-surgical treatment and management protocols for POP patients and self-management of POP patients.

Objective To explore the value of Vision Transformer(ViT)fusion network assisted multiparametric MRI for diagnosing intracranial large vessel stenosis/occlusion(LVSO).Methods Totally 221 cases of ischemic stroke(IS)were retrospectively enrolled as test set,while other 28 cases of IS were taken as validation set,and data of diffusion weighted imaging(DWI),3D pseudo-continuous arterial spin labeling(3D-pCASL)and CT angiography(CTA)were collected.Taken CTA as reference standard,the value of ViT fusion network based on DWI,3D-pCASL and their combination for diagnosing intracranial LVSO were observed.Results In test set,the area under the curve(AUC)of ViT fusion network based on DWI,3D-pCASL and their combination for diagnosing intracranial LVSO was 0.879,0.908 and 0.925,respectively,no significant difference was found between each two(all P＞0.05),but AUC of DWI+3D-pCASL was slightly higher than that of the other two.In validation set,the AUC of ViT fusion network based on DWI+3D-pCASL for diagnosing intracranial LVSO was 0.850.Conclusion The performance of ViT fusion network based on DWI combined with 3D-pCASL for diagnosing intracranial LVSO was better.

This paper reports a case of hepatoblastoma that is inclined to misdiagnosis and missed diagnosis. The patient, a 6-month-old male, was admitted to Dermatology Department of Children’s Hospital of Nanjing Medical University and Beijing Children’s Hospital successively, because of a erythema on the neck for 6 months and a mass in the neck for 3 months. Abdominal ultrasonography and CT indicated the possibility of hepatic hemangioma, but further examination of alpha fetoprote and other indicators suggested hepatic malignant tumor. Therefore, surgery was performed to remove the liver mass, and postoperative pathology revealed hepatoblastoma. Postoperative chemotherapy was combined, and follow-up was conducted six months after the end of chemotherapy, with no recurrence of the disease. This article summarized the diagnosis and treatment process of this case and combined with literature review to provide experience for clinicians in the diagnosis and treatment of relevant cases.

Aim To figure out whether Lonicera mac-ranthoides could induce hemolysis. Methods In vitro, macroscopic observation and spectrophotometry were used to observe whether the solutions of extracts from Lonicera macranthoides, MacranthoidinB and Dipsa-cosideB could induce hemolysis in 2% red cell suspen-sion of New Zealand white rabbits. And the three test-ed materials were prepared in concentration gradient of 5, 10, 20, 30, 40, 50, 60, 70, 80, 90, 100 mg· L - 1; and in vivo, mice were respectively treated with MacranthoidinB (0. 110 g·kg - 1 , 0. 055 g·kg - 1 ), DipsacosideB(0. 020 g·kg - 1 , 0. 010 g·kg - 1 ), ex-tracts (2. 275 g·kg - 1 , 1. 137 g·kg - 1 , crude drugs) once per day for 7 days, and all of the tested doses de-pended on the clinical doses. Then, RBC, RET and MCHC before and after administration were tested. Re-sults The hemolytic ratio in each treated group was below 5% in vitro. And in vivo, the three materials did not induce hemolysis and had no significant influence on RBC,RET and MCHC(P > 0. 05). Conclusions Extracts from flower bud of Lonicera macranthoides, MacranthoidinB and DipsacosideB, have not caused hemolysis in vivo and in vitro in this research.

Objective To analyze the clinical characteristics of children tsutsugamushi infection in order to strengthen understanding,reduce the misdiagnosis rate,reduce the complications and improve the level of diagnosis and treatment.Methods To analyze retrospectively the clinical data and treatment outcome of 22 cases of children tsutsugamushi disease,including symptoms,physical signs and laboratory examination.Results All the cases with fever onset,high fever (＞ 39 ℃) was 72.7％ (16/22),all cases were typical eschars and ulcers,while 8 cases (36.4％,8/22)had lymphadenectasis.Merger multiple organ damage in 14 cases (63.6％,14/22),anemia in 11 cases (50.0％,11/22)and liver function abnormal in 4 cases (18.2％,4/22).All of 22 cases were treated with azithromycin.All cases after treatment with azithromycin heal,no recurrence.Conclusions The manifestation of tsutsugamushi disease is diversity,much complications,among which hematology and liver are the most common cases.Physical examination roundly might reduce missed diagnosis and misdiagnosis as greatly as possible.Azithromycin has good therapeutic effects on children tsutsgamushi disease.