Objective:To analyze the risk factors of prognosis in patients with intracranial solitary fibrous tumor/hemangiopericytoma (SFT/HPC).Methods:The clinical data of 74 intracranial SFT/HPC patients underwent surgical treatment from January 2017 to January 2024 in Luhe Hospital, Capital Medical University and Sanbo Brain Hospital, Capital Medical University were retrospectively analyzed. The patients were followed up the prognosis (including recurrence, death and extracranial metastasis). Kaplan-Meier and log-rank tests were used to analyze the risk factors of prognosis in patients with intracranial SFT/HPC, and multivariate Cox analysis was used to analyze the independent risk factors of prognosis in patients with intracranial SFT/HPC.Results:Seventy-four patients with intracranial SFT/HPC were followed up for 3 to 80 months, averaging 52.5 months. Among them, there were 17 cases of recurrence, 6 cases of extracranial metastasis, and 12 cases of death. In patients with intracranial SFT/HPC, the results of the log-rank univariate analysis showed that the tumor location, resection extent, WHO pathological grade, and adjuvant radiotherapy were risk factors of recurrence ( P<0.01); the tumor location, WHO pathological grade and extracranial metastasis were risk factors of death ( P<0.05 or <0.01); and the age, WHO pathological grade and Ki67 were risk factors of extracranial metastasis ( P<0.05 or <0.01). In patients with intracranial SFT/HPC, multivariate Cox regression analysis result showed that the subtotal resection and non-postoperative radiation therapy were independent risk factors of recurrence ( HR = 0.377 and 0.315, 95% CI 0.148 to 0.932 and 0.164 to 2.221, P<0.01 and <0.05); the WHO pathological grade Ⅲ and extracranial metastasis were independent risk factors of death ( HR = 3.657 and 1.657, 95% CI 0.964 to 7.147 and 0.964 to 2.848, P<0.01); the WHO pathological grade Ⅲ was an independent risk factor of extracranial metastasis ( HR = 1.657, 95% CI 0.964 to 2.848, P<0.01). Conclusions:Patients with intracranial SFT/HPC who undergo subtotal resection and non-postoperative radiation therapy are more prone to recurrence, WHO pathological grade Ⅲ patients are more likely to develop extracranial metastases, and extracranial metastases patients have shorter survival. For intracranial SFT/HPC patients with pathologically high-grade, SFT/HPC, it is necessary to increase the frequency of follow-ups and be alert for extracranial metastasis.

With the increasing incidence of chronic diseases,the research is conducted to actively explore out of hospital management models for chronic disease patients globally.Among them,virtual ward is a management model based on multidisciplinary team collaboration to provide professional medical and nursing services for unplanned hospitalization high-risk population.This model not only facilitates the transition of patients from inpatient settings to home environments,improving disease prognosis and reducing hospitalization risk,but also alleviates the bed burden on large hospitals.This article provides a review of the concept,development,construction of the operational system,and patient management processes of virtual wards,and offers insights and suggestions to provide references for the optimization and development of out of hospital management models for chronic disease patients in China.

BACKGROUND: Spicy food consumption has been reported to be inversely associated with mortality from multiple diseases. However, the effect of spicy food intake on the incidence of vascular diseases in the Chinese population remains unclear. This study was conducted to explore this association. METHODS: This study was performed using the large-scale China Kadoorie Biobank (CKB) prospective cohort of 486,335 participants. The primary outcomes were vascular disease, ischemic heart disease (IHD), major coronary events (MCEs), cerebrovascular disease, stroke, and non-stroke cerebrovascular disease. A Cox proportional hazards regression model was used to assess the association between spicy food consumption and incident vascular diseases. Subgroup analysis was also performed to evaluate the heterogeneity of the association between spicy food consumption and the risk of vascular disease stratified by several basic characteristics. In addition, the joint effects of spicy food consumption and the healthy lifestyle score on the risk of vascular disease were also evaluated, and sensitivity analyses were performed to assess the reliability of the association results. RESULTS: During a median follow-up time of 12.1 years, a total of 136,125 patients with vascular disease, 46,689 patients with IHD, 10,097 patients with MCEs, 80,114 patients with cerebrovascular disease, 56,726 patients with stroke, and 40,098 patients with non-stroke cerebrovascular disease were identified. Participants who consumed spicy food 1-2 days/week (hazard ratio [HR] = 0.95, 95% confidence interval [95% CI] = [0.93, 0.97], P <0.001), 3-5 days/week (HR = 0.96, 95% CI = [0.94, 0.99], P = 0.003), and 6-7 days/week (HR = 0.97, 95% CI = [0.95, 0.99], P = 0.002) had a significantly lower risk of vascular disease than those who consumed spicy food less than once a week ( Ptrend <0.001), especially in those who were younger and living in rural areas. Notably, the disease-based subgroup analysis indicated that the inverse associations remained in IHD ( Ptrend = 0.011) and MCEs ( Ptrend = 0.002) risk. Intriguingly, there was an interaction effect between spicy food consumption and the healthy lifestyle score on the risk of IHD ( Pinteraction = 0.037). CONCLUSIONS Our findings support an inverse association between spicy food consumption and vascular disease in the Chinese population, which may provide additional dietary guidance for the prevention of vascular diseases.
Humans ; Male ; Female ; Prospective Studies ; Middle Aged ; Aged ; Vascular Diseases/etiology* ; Risk Factors ; China/epidemiology* ; Adult ; Proportional Hazards Models ; Cerebrovascular Disorders/epidemiology* ; East Asian People

With the increasing incidence of chronic diseases,the research is conducted to actively explore out of hospital management models for chronic disease patients globally.Among them,virtual ward is a management model based on multidisciplinary team collaboration to provide professional medical and nursing services for unplanned hospitalization high-risk population.This model not only facilitates the transition of patients from inpatient settings to home environments,improving disease prognosis and reducing hospitalization risk,but also alleviates the bed burden on large hospitals.This article provides a review of the concept,development,construction of the operational system,and patient management processes of virtual wards,and offers insights and suggestions to provide references for the optimization and development of out of hospital management models for chronic disease patients in China.

Objective To explore current status and potential subtypes of elderly stroke patients' medication literacy among,and to analyze related influencing factors of different subtypes.Methods A total of 285 elderly stroke patients admitted in the First Affiliated Hospital of Zhengzhou University from November 2023 to June 2024 were selected as subjects.General Information questionnaire,medication literacy scale for elderly patients with chronic diseases,and perceived social support scale were conducted.Latent profile analysis(LPA)of elderly stroke patients' medication literacy was conducted,and Logistic regression analysis was used to explore influencing factors of different profiles.Results Score of medication literacy scale for elderly stroke patients was(48.26±12.51)points.Medication literacy among elderly stroke patients can be divided into 3 profiles,namely proactive-high literacy type(51.9％),balanced-medium literacy type(34.0％),and dependent-low literacy type(14.1％).Logistic regression analysis showed that recent medication types,current place of residence,educational level,diabetes,and social support were the influencing factors of elderly stroke patients' medication literacy(P＜0.05).Conclusion The level of medication literacy among elderly stroke patients is medium,which is characterized by 3 categories.Medical staffs targeted intervention should be adopted according to different category characteristics,so as to accurately meet their nursing needs,finally improve the level of elderly stroke patients' medication literacy.

Objective To observe the clinical efficacy of regulating conception vessel and unblocking governor vessel electroacupuncture in the treatment of cancer-related fatigue(CRF)of middle-to-advanced stage cervical cancer,and to explore its effect on inflammatory factors.Methods A total of 122 patients with a definitive diagnosis of CRF of middle-to-advanced stage cervical cancer admitted to the wards and outpatient clinics of Cangzhou Central Hospital from August 2021 to August 2023 were selected for the study.The patients were randomly divided into the control group and the observation group according to the random number table method,with 61 cases in each group.The patients in both groups were given conventional symptomatic treatments such as gastric protection and anti-vomiting since the day of action of chemotherapy.The control group was treated with Dexamethasone Tablets,and the observation group was treated with regulating conception vessel and unblocking governor vessel electroacupuncture on the basis of the control group,the course of treatment covered 21 days.After three weeks of treatment,the clinical efficacy of the two groups was evaluated.The changes in the traditional Chinese medicine(TCM)syndrome scores,Piper's Fatigue Scale(PFS)scores,Karnofsky Performance Status(KPS)scores,and Functional Assessment of Cancer Therapy-General(FACT-G)scores of the patients in the two groups before and after treatment were observed.The changes in interleukin 6(IL-6),hypersensitive C-reactive protein(hs-CRP),tumor necrosis factor α(TNF-α),and T-lymphocyte subsets indicators[CD3+,CD4+,CD8+,CD4+/CD8+]were compared between the patients in the two groups before and after treatment.Results(1)The total effective rate was 95.08%(58/61)in the observation group and 77.05%(47/61)in the control group.The efficacy of the observation group was superior to that of the control group,the difference being statistically significant(P<0.05).(2)After treatment,the TCM syndrome scores of patients in the two groups were significantly improved(P<0.05),and the improvement in the observation group was significantly superior to that in the control group,the difference being statistically significant(P<0.05).(3)After treatment,the PFS scores of patients in the two groups were improved significantly(P<0.05),and the improvement in the observation group was significantly superior to that in the control group,the difference being statistically significant(P<0.05).(4)After treatment,the serum IL-6,hs-CRP,and TNF-α levels of patients in the two groups were significantly improved(P<0.05),and the improvement in the observation group was significantly superior to that in the control group,the difference being statistically significant(P<0.05).(5)After treatment,the CD3+,CD4+,CD8+,CD4+/CD8+of patients in the two groups were significantly improved(P<0.05),and the improvement in the observation group was significantly superior to that in the control group,the difference being statistically significant(P<0.05).(6)After treatment,the KPS scores and FACT-G scores of patients in the two groups were significantly improved(P<0.05),and the improvement in the observation group was significantly superior to that in the control group,the difference being statistically significant(P<0.05).Conclusion Regulating conception vessel and unblocking governor vessel electroacupuncture in the treatment of CRF of middle-to-advanced stage cervical cancer can effectively alleviate the fatigue of patients,inhibit the release of inflammatory factors,regulate the immune function,and improve the physical condition of patients,so as to improve the quality of life of patients.

Objective:To analyze the risk factors of prognosis in patients with intracranial solitary fibrous tumor/hemangiopericytoma (SFT/HPC).Methods:The clinical data of 74 intracranial SFT/HPC patients underwent surgical treatment from January 2017 to January 2024 in Luhe Hospital, Capital Medical University and Sanbo Brain Hospital, Capital Medical University were retrospectively analyzed. The patients were followed up the prognosis (including recurrence, death and extracranial metastasis). Kaplan-Meier and log-rank tests were used to analyze the risk factors of prognosis in patients with intracranial SFT/HPC, and multivariate Cox analysis was used to analyze the independent risk factors of prognosis in patients with intracranial SFT/HPC.Results:Seventy-four patients with intracranial SFT/HPC were followed up for 3 to 80 months, averaging 52.5 months. Among them, there were 17 cases of recurrence, 6 cases of extracranial metastasis, and 12 cases of death. In patients with intracranial SFT/HPC, the results of the log-rank univariate analysis showed that the tumor location, resection extent, WHO pathological grade, and adjuvant radiotherapy were risk factors of recurrence ( P<0.01); the tumor location, WHO pathological grade and extracranial metastasis were risk factors of death ( P<0.05 or <0.01); and the age, WHO pathological grade and Ki67 were risk factors of extracranial metastasis ( P<0.05 or <0.01). In patients with intracranial SFT/HPC, multivariate Cox regression analysis result showed that the subtotal resection and non-postoperative radiation therapy were independent risk factors of recurrence ( HR = 0.377 and 0.315, 95% CI 0.148 to 0.932 and 0.164 to 2.221, P<0.01 and <0.05); the WHO pathological grade Ⅲ and extracranial metastasis were independent risk factors of death ( HR = 3.657 and 1.657, 95% CI 0.964 to 7.147 and 0.964 to 2.848, P<0.01); the WHO pathological grade Ⅲ was an independent risk factor of extracranial metastasis ( HR = 1.657, 95% CI 0.964 to 2.848, P<0.01). Conclusions:Patients with intracranial SFT/HPC who undergo subtotal resection and non-postoperative radiation therapy are more prone to recurrence, WHO pathological grade Ⅲ patients are more likely to develop extracranial metastases, and extracranial metastases patients have shorter survival. For intracranial SFT/HPC patients with pathologically high-grade, SFT/HPC, it is necessary to increase the frequency of follow-ups and be alert for extracranial metastasis.

Objective To explore current status and potential subtypes of elderly stroke patients' medication literacy among,and to analyze related influencing factors of different subtypes.Methods A total of 285 elderly stroke patients admitted in the First Affiliated Hospital of Zhengzhou University from November 2023 to June 2024 were selected as subjects.General Information questionnaire,medication literacy scale for elderly patients with chronic diseases,and perceived social support scale were conducted.Latent profile analysis(LPA)of elderly stroke patients' medication literacy was conducted,and Logistic regression analysis was used to explore influencing factors of different profiles.Results Score of medication literacy scale for elderly stroke patients was(48.26±12.51)points.Medication literacy among elderly stroke patients can be divided into 3 profiles,namely proactive-high literacy type(51.9％),balanced-medium literacy type(34.0％),and dependent-low literacy type(14.1％).Logistic regression analysis showed that recent medication types,current place of residence,educational level,diabetes,and social support were the influencing factors of elderly stroke patients' medication literacy(P＜0.05).Conclusion The level of medication literacy among elderly stroke patients is medium,which is characterized by 3 categories.Medical staffs targeted intervention should be adopted according to different category characteristics,so as to accurately meet their nursing needs,finally improve the level of elderly stroke patients' medication literacy.

Objective By population survey,to explore the epidemiological characteristics of gastric precancerous lesions in Lishui District of Nanjing and provide objective basis for the prevention and treatment of early gastric cancer.Methods From July 2021 to December 2022,21 977 patients who received endoscopy and/or 13C-UBT in Lishui District People's Hospital and 6 medical community units in Nanjing City were retrospectively analyzed for demography characteristics,detection rate of gastric precancerous lesions,and H.Pylori infection rate.Results(1)590 cases of gastric precancerous lesions were detected(detection rate 2.68%);(2)The total detection rate of precancerous lesions and three pathological types in males were all higher than those in females(all P<0.001);(3)The minimum age for the total detection rate of precancerous lesions in males and the mini-mum age for each pathological type were lower than in females(P<0.001,0.009,0.005,0.002);(4)The popu-lation total H.pylori infection rate was 23.10%,the H.pylori infection rate in patients with precancerous lesions was higher than that in non-precancerous lesions(P<0.001),both H.pylori infection rate of male and female in precancerous lesions were all higher than those of non-precancerous lesions of the same sex(all P<0.001),in addition,the H.pylori infection rate of male whether in precancerous or non-precancerous lesions was higher than that of female(all P<0.001);(5)The precancerous lesions detection rate in male,female,and the overall age range of 20～29 to 70～79 years is positively correlated with age growth(P<0.001),and rapidly decreases after the age of 79,the of H.pylori infection rate was also positively correlated with age growth(P<0.001),and the trend of age change(P<0.001)was parallel to the precancerous lesions detection rate.Conclusions The detec-tion rate of gastric precancerous lesions in this region is above the average level in China;the total H.pylori infec-tion rate is at a relatively low level in China;the H.pylori infection rate is parallel to the age trend of the detection rate of gastric precancerous lesions,and increases with age.

Age-related macular degeneration(AMD)is a common irreversible blinding eye disease in the elderly char-acterized by choroidal neovascularization in the macular area.Thyroxine and its receptors are significantly expressed in the retina,and free thyroid hormones are closely related to the occurrence and development of AMD.This article summarizes the basic and clinical research progress of thyroxine in AMD,in order to provide scientific theoretical basis for further ex-ploring the pathogenesis of AMD and better prevention and treatment of the disease.