Objective:To explore the clinical application value of magnetic resonance imaging (MRI)-guided wire localization to the non-palpable breast lesions (NPBL) identified on MRI only.Methods:A retrospective case series study was conducted. A total of 171 patients with NPBL identified on MRI only who underwent MRI-guided wire localization from April 2017 to May 2024 in Shaanxi Provincial Cancer Hospital were collected. All patients had breast MRI Breast Imaging Report and Data System (BI-RADS) 4a and above lesions, and underwent MRI-guided wire localization within the same menstrual cycle within 2 days to 2 months after diagnostic MRI examination. Based on postoperative pathological results, the MRI characteristics of benign and malignant lesions were compared, and the clinical application value of MRI-guided wire localization was evaluated.Results:There were 179 lesions in 171 patients, including 54 malignant lesions (30.17%) and 125 benign lesions (69.83%). There was no statistically significant difference in the enhancement morphology between pathological benign and malignant NPBL lesions ( χ2 = 0.04, P = 0.982), while there were statistically significant differences in breast background parenchymal enhancement, lesion time-signal intensity curve and BI-RADS classification ( χ2 values were 32.03, 20.72 and 37.60, respectively, all P < 0.05). Conclusions:For NPBL that is identified on MRI only and evaluated as BI-RDADS 4a or above, MRI-guided wire localization can improve the accuracy of diagnosis and treatment of intraductal carcinoma, early invasive cancer and high-risk lesions.

Objective:To explore the clinical application value of magnetic resonance imaging (MRI)-guided wire localization to the non-palpable breast lesions (NPBL) identified on MRI only.Methods:A retrospective case series study was conducted. A total of 171 patients with NPBL identified on MRI only who underwent MRI-guided wire localization from April 2017 to May 2024 in Shaanxi Provincial Cancer Hospital were collected. All patients had breast MRI Breast Imaging Report and Data System (BI-RADS) 4a and above lesions, and underwent MRI-guided wire localization within the same menstrual cycle within 2 days to 2 months after diagnostic MRI examination. Based on postoperative pathological results, the MRI characteristics of benign and malignant lesions were compared, and the clinical application value of MRI-guided wire localization was evaluated.Results:There were 179 lesions in 171 patients, including 54 malignant lesions (30.17%) and 125 benign lesions (69.83%). There was no statistically significant difference in the enhancement morphology between pathological benign and malignant NPBL lesions ( χ2 = 0.04, P = 0.982), while there were statistically significant differences in breast background parenchymal enhancement, lesion time-signal intensity curve and BI-RADS classification ( χ2 values were 32.03, 20.72 and 37.60, respectively, all P < 0.05). Conclusions:For NPBL that is identified on MRI only and evaluated as BI-RDADS 4a or above, MRI-guided wire localization can improve the accuracy of diagnosis and treatment of intraductal carcinoma, early invasive cancer and high-risk lesions.

Objective To investigate the expression of protein interacting with Cα kinase 1 (PICK1) and its significance in colorectal adenocarcinoma.Methods The expression of PICK1 were detected by immunohistochemistry and Western blot methods in tissues of colorectal adenocarcinoma,colorectal adenoma,colorectal polyp and adjacent tissues.The correlation between PICK1 and clinical pathological data was explored.Results Immunohistochemical assay showed that the positive ratio of PICK1 protein was 72.5 ％ (74/102),and overexpressed in 31 cases (30.4 ％,31/102) with colorectal adenocarcinoma.The ratio of high expression level of PICK1 in colorectal adenoma tissues (22.2 ％,8/36) was significantly higher than that in the adjacent tissues (0,0/40) (P ＜ 0.05).The ratio of high expression level of PICK1 in colorectal polyp tissues (5.6 ％,2/36) was no statistically difference compared with that of the adjacent tissues (P ＞ 0.05).Western blot analysis revealed that the expression of PICK1 in colorectal adenocarcinoma (1.10±0.04) was significantly higher than that in the adjacent tissues (0.75±0.07) (P ＜ 0.05).The result showed significant correlation with the tumor location,the degree of differentiation,depth of invasion,TNM stages and lymph metastasis (all P ＜ 0.05).However,there is no correlation was revealed between PICK1 expression and the patients age,gender (both P ＞ 0.05).Conclusion The expression of PICK1 may be associated with the tumorgenesis,progression,invasion and metastasis of colorectal adenocarcinoma,which contributes to the prognosis of patients.