Background::Schizophrenia (SCZ) is a complex psychiatric disorder associated with widespread alterations in the subcortical brain structure. Hemispheric asymmetries are a fundamental organizational principle of the human brain and relate to human psychological and behavioral characteristics. We aimed to explore the state of thalamic lateralization of SCZ.Methods::We used voxel-based morphometry (VBM) analysis, whole-brain analysis of low-frequency fluctuations (ALFF), fractional amplitude of low-frequency fluctuations (fALFF), and resting-state seed-based functional connectivity (FC) analysis to investigate brain structural and functional deficits in SCZ. Also, we applied Pearson's correlation analysis to validate the correlation between Positive and Negative Symptom Scale (PANSS) scores and them.Results::Compared with healthy controls, SCZ showed increased gray matter volume (GMV) of the left thalamus ( t = 2.214, p = 0.029), which positively correlated with general psychosis ( r = 0.423, p = 0.010). SCZ also showed increased ALFF in the putamen, the caudate nucleus, the thalamus, fALFF in the nucleus accumbens (NAc), and the caudate nucleus, and decreased fALFF in the precuneus. The left thalamus showed significantly weaker resting-state FC with the amygdala and insula in SCZ. PANSS negative symptom scores were negatively correlated with the resting-state FC between the thalamus and the insula ( r = -0.414, p = 0.025). Conclusions::Collectively, these results suggest the possibility of aberrant laterality in the left thalamus and its FC with other related brain regions involved in the limbic system.

Background::Schizophrenia (SCZ) is a complex psychiatric disorder associated with widespread alterations in the subcortical brain structure. Hemispheric asymmetries are a fundamental organizational principle of the human brain and relate to human psychological and behavioral characteristics. We aimed to explore the state of thalamic lateralization of SCZ.Methods::We used voxel-based morphometry (VBM) analysis, whole-brain analysis of low-frequency fluctuations (ALFF), fractional amplitude of low-frequency fluctuations (fALFF), and resting-state seed-based functional connectivity (FC) analysis to investigate brain structural and functional deficits in SCZ. Also, we applied Pearson's correlation analysis to validate the correlation between Positive and Negative Symptom Scale (PANSS) scores and them.Results::Compared with healthy controls, SCZ showed increased gray matter volume (GMV) of the left thalamus ( t = 2.214, p = 0.029), which positively correlated with general psychosis ( r = 0.423, p = 0.010). SCZ also showed increased ALFF in the putamen, the caudate nucleus, the thalamus, fALFF in the nucleus accumbens (NAc), and the caudate nucleus, and decreased fALFF in the precuneus. The left thalamus showed significantly weaker resting-state FC with the amygdala and insula in SCZ. PANSS negative symptom scores were negatively correlated with the resting-state FC between the thalamus and the insula ( r = -0.414, p = 0.025). Conclusions::Collectively, these results suggest the possibility of aberrant laterality in the left thalamus and its FC with other related brain regions involved in the limbic system.

Age-related macular in human retinal results in strict loss and enduring decrease in visual acuity. A lot of medical evidence has shown that macular degeneration, associated with Choroidal neovascularization (CNV), leads to irreversible injure in composition and function of retinal tissue. A new analytical and restorative treatment, scotoma-based photocoagulation (SPB), curdles the affected areas so effectively and timely that it can delay or prevent age-related macular degeneration (AMD). A scanning laser ophthalmoscope (SLO) image is involved and the function and character of scotometry are analyzed. Combining anatomical and pathological features, this paper introduces process of acquiring the image and algorithms of analyzing it. Furthermore, integrate image of retinal is extracted from SLO through feature extraction, special registration and superimposition. The treatment can be applied to clinical diagnosis without great revisions and provide direction for pertinent fields.