1.Persistent SARS-CoV-2 Infection in a Patient Who Developed COVID-19 While Receiving Rituximab: A Case Report
Toshiaki MOTEGI ; Shigen HAYASHI ; Kenta NAKAMURA ; Kenya KURAMOTO ; Tatsuya AKIYAMA ; Hiroshi EBE ; Hirofumi SAKURAI ; Akihiro NOMURA
Journal of the Japanese Association of Rural Medicine 2025;74(4):397-402
This case involves a man in his 60s who was undergoing rituximab therapy and developed COVID-19 pneumonia and showed persistent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Despite treatments with dexamethasone, remdesivir, tocilizumab, and other drugs, the patient remained SARS-CoV-2 positive and ultimately died of respiratory failure. Patients receiving B-cell depletion therapy have an increased risk of persistent viral infections due to immunosuppression, underscoring the importance of early intervention with antiviral drugs and neutralizing antibodies in such cases.
2.EPIDEMIOLOGICAL STUDY OF INFLUENZA VIRUS INFECTIONS IN YANGON, MYANMAR
GO HASEGAWA ; YADANAR KYAW ; HLA MYAT NEW ; LI DANJUAN ; REIKO SAITO ; HIROSHI SUZUKI ; YUSUKE EBE ; TIN MAUNG CHO ; MAKOTO NAITO
Tropical Medicine and Health 2006;34(1):3-6
Although influenza is a highly contagious acute respiratory illness of global importance, little is known about the disease in tropical countries. An influenza survey was conducted in three sentinel sites in Yangon, Myanmar from September 2003 to December 2004. Throat or nasal swabs were collected from 616 patients with influenza-like symptoms and tested using rapid diagnostic test kits and virus isolation. Influenza B virus was detected in 6 patients from September to October, 2003. Influenza A viruses were detected in 133 patients from June to September, 2004, and the 51 influenza A viruses isolated from 72 specimens were all A⁄H3N2. Influenza virus infections occurred mainly in the rainy season in Yangon, Myanmar, but continuous ongoing influenza surveillance is needed.


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