Background/Aims: Sufficient sedation is important when performing an endoscopic submucosal dissection (ESD) for an esophageal squamous cell carcinoma (ESCC), and dexmedetomidine (DEX) is being increasingly used. ESD is often performed in elderly patients and those with comorbidities. Therefore, adverse events (AEs) in the circulatory and respiratory systems remain a clinical concern.Despite this, limited data exist on these AEs, so this study was conducted to investigate this issue. Methods: This single-center retrospective study included 526 patients who underwent ESD for ESCC under DEX-based sedation from 2016 to 2023. The study assessed the incidence of AEs in circulatory and respiratory systems, as well as the risk factors associated with these events. Various clinical factors, including the Prognostic Nutritional Index (PNI), were analyzed as candidates. Results: Circulatory AEs occurred in 55 cases (10.5%), including bradycardia (7.2%) and hypotension (4.2%). Univariate and multivariate analyses revealed significant associations of lower PNI (<45) and prolonged procedure time with circulatory AEs (p=0.023 and p=0.008, respectively). Respiratory AEs occurred in 12 cases (2.3%), including respiratory depression (1.0 %) and post-ESD pneumonia (1.5 %) with one fatal case (0.2 %). An analysis of respiratory AEs showed that the elderly (≥80 years) and lower PNI were significant in univariate analysis but not in multivariate analysis (both p=0.07). Conclusions When performing ESD for ESCC under DEX-based sedation, special caution is needed for patients with lower PNI and the elderly, who are more likely to experience circulatory or respiratory complications.

Case reports are studies that document the detailed progression of a single case, representing the most accessible research style for clinicians. Even a single case can provide insights that may hint at directions for future research and clinical practice, and enhancing the quality of case reports can strengthen the scientific foundation of acupuncture. Therefore, it is advisable for acupuncturists to actively pursue case reporting based on their daily clinical experiences. However, to make case reports meaningful, they must be correctly "evaluated." Evaluation in acupuncture practice is broadly divided into assessment of the condition and the outcomes of treatment. The assessment of the condition involves understanding the patient's current state through consultation and physical examination, while outcome evaluation assesses changes in the patient following treatment. Here, "evaluation" refers to the latter-observing changes in patient outcomes. We discussed how patient outcomes are assessed in daily practice, how these assessments are utilized, and how they can lead to presentations at academic conferences, aiming to help with those who are one step away from making such conference presentations.

【Introduction】Thumbtack needles for skin stimulation are used in the field of sports medicine. Their primary therapeutic mechanism is believed to be the increase in regional blood flow mediated by the axon reflex. However, it is not clear at this time whether a medical device (acupuncture device) for skin stimulation significantly increases regional blood flow at the stimulation site. Furthermore, sterile acupuncture needles in which the acupuncture needle body is inserted into the skin with multiple needles (hereafter referred to as Multi-core thumbtack needle) have not been manufactured to date, and their usefulness and potential application for blinding is unknown.【Materials and Methods】A single-blind randomized crossover trial was conducted in 16 healthy adult males. A multi-core thumbtack needle (needle length 0.55 mm, needle base diameter 0.3 mm, number of needles 37, pitch 1.0 mm, made of biosafe resin) was placed in the center of the palmar side of the forearm for 30 seconds, and then one week later they were randomly assigned in a 1:1 ratio to one group to receive stimulation in the same way with a sham needle (a flat disk made of the same material), or one group to receive stimulation in the opposite order. The primary endpoints were the change in regional blood flow (5 min post-stimulation vs. pre-stimulation) and the rate of change at the stimulation site, which were measured using a laser perfusion meter. The secondary endpoint was heart rate. A linear mixed model was used as the statistical method, with a significance level of 5%.【Results】Regarding the amount of change in regional blood flow, sham needles showed a mean of -0.09 (95% confidence interval [CI]: -0.39 to 0.21) mL/min/100g, whereas multi-core thumbtack needles showed a mean of 8.83 (95% CI: 5.86 to 11.79) mL/min/100g, indicating a significant intervention effect (P < 0.001), with no significant period effect (P = 0.474) or carryover effect (P = 0.441). There was no intervention effect on heart rate (P = 0.95).【Conclusion】A significant increase in local blood flow was observed with the use of the multi-core thumbtack needle employed in this study. As this response was not accompanied by a significant increase in heart rate, it is speculated that the effect is primarily mediated by the axonal reflex and the involvement of nitric oxide, as well as somatic-autonomic reflex mechanisms.

[Introduction] The domestic market for medical devices is expected to increase steadily against the backdrop of growing medical needs due to the aging population. This will create more business opportunities for medical device manufacturers. However, clarity regarding the domestic market for the medical device category "acupuncture and moxibustion apparatus" is poor, and information is lacking for companies to use when considering implementing new business development strategies.[Materials and Methods] Data from the "Statistics of Production by Pharmaceutical Industry" for the last five years (2019-2023) were used as the information source, and medical devices categorized as "acupuncture and moxibustion apparatus" were analyzed.[Results] The average domestic market size (production value + import value - export value) for acupuncture and moxibustion devices over the past five years was 7,141,948,800 JPY (95% confidence interval: 6,095,584,238-8,112,805,362), and the average annual growth rate was -4.29%. In terms of the average annual growth rate by generic name, "home-use affixed contact grains" (12.8%) had the largest growth rate; "warm moxibustion devices" (9.3%) and "non-invasive home-use acupuncture and moxibustion devices" (5.7%) showed positive growth; while "reusable acupuncture needles" (-1.3%), sterilized needles" (-5.8%), and "non-active contact needles" (-23.8%) showed negative growth.[Conclusion] Among devices in the category "acupuncture and moxibustion devices", "home-use affixed contact grains", "warm moxibustion devices", and "non-invasive home-use acupuncture and moxibustion devices" showed positive growth over the past five years. Thus, these are the medical device categories for which new business development can be expected.

[Objective] Premature ventricular contraction (PVC) causes arrhythmia, and it most frequently occurs in healthy individuals. It has been recently reported that a combination of medical therapy and acupuncture has an effect on arrhythmia. Herein, we report on the use of acupuncture in a patient with PVC.[Case] A 41-year-old male complained of arrhythmia and stiff shoulders. According to the Lown grading system, he was diagnosed with a grade 1 condition using Holter monitor in a hospital for internal diseases. Acupuncture was applied for decreasing the PVC count and discomfort in the chest region.[Methods] Acupuncture was applied at points PC6, BL15, HT7, ST36, GV20, CV17, and KI3. Manipulation involved twirling the stemless needle (30 mm in length, 0.20 mm in diameter) at a low amplitude and high frequency, and the needle was then retained for 10 min. The treatment was applied twice a day for four weeks. Measurements were obtained using a visual analog scale, SF-36v2, and Holter monitor.[Results] After four weeks of treatment, discomfort in the chest region decreased and quality of life improved. Additionally, the PVC count decreased after two weeks of treatment.[Conclusion] Our findings suggest that acupuncture is effective for treatment of PVC.

[Background] Presenteeism, defined as the practice of sick workers who come to work, and whose work performance effectiveness has been reduced due to various signs and symptoms, causes a significant financial loss to companies. However, comprehensive and effective occupational health countermeasures have not yet been presented. Therefore, we report here the results of an interim analysis to determine whether an allowance for acupuncture treatment is beneficial for workers' presenteeism. [Methods] A four-week randomized intergroup comparative study was conducted on office workers who were aware of their presenteeism. Participants were allocated to either the control group, in which regular recommended presenteeism countermeasures for each workplace were implemented arbitrarily, or to the intervention group in which an allowance of up to 8,000 was given for acupuncture treatment, in addition to the usual arbitrary measures. The primary endpoint was the WHO-HPQ relative presenteeism score: a score lower than 1 indicates lower work performance; and it was analyzed with the "full analysis set" population.[Results] A total of 52 patients were assigned to the intervention group (n = 30) and the control group (n = 22). On average, the intervention group received acupuncture treatments 1.4 times for stiff neck and shoulders (67%), lower back pain (26%), depression (5%), and allergies (2%), and paid a total of 7,219; and 6,556 was paid as an expense allowance. As a result, the relative presenteeism score was 0.95 in the intervention group, compared to 0.91 in the control group, with a between-group difference of 0.04 (ES (r) = 0.22, P = 0.12).[Conclusions] With a total of up to 8,000 offered to office workers who were aware of their presenteeism, an acupuncture treatment allowance for a four-week period was provided 1.4 times on average. The results suggested that the treatment allowance would increase workers' performance efficiency by about 4% (equivalent to 19,691 per person) compared to those without it.