Objective To investigate the short-term efficacy and prognostic factors of donafenib combined with transcatheter arterial chemoembolization(TACE)in the treatment of spontaneously ruptured hepatocellular carcinoma.Methods A retrospective analysis was conducted on the data of patients diagnosed with spontaneously ruptured hepatocellular carcinoma.According to the treatment meth-ods,patients were categorized into simple group(TACE)and combined group(donafenib combined with TACE).Median progres-sion-free survival(mPFS),objective remission rate(ORR),disease control rate(DCR),and median overall survival(mOS)were calculated,and treatment-related adverse events were counted.Finally,prognostic survival factors were analyzed by Cox regression.Results The mPFS for the simple group was 4.6 months,compared to 13.6 months for the combined group(χ2=9.081,P=0.003).Similarly,the mOS for the simple group was 7.6 months,compared to 17.4 months for the combined group(χ2=6.351,P=0.012).Both mPFS and mOS were significantly lower in the simple group than those in the combined group.The ORR of 25.7%and DCR of 57.1%in the simple group were significantly lower than the ORR of 55.6%and DCR of 81.5%in the combined group,and the difference between the two groups was statistically significant(P<0.05).However,there was no statistically significant difference in the incidence of rebleeding,abdominal pain and fever between the two groups(P>0.05).Additionally,age,portal vein tumor thrombus(PVTT),Child-Pugh grade,tumor diameter,and total biliru-bin(TBIL)were identified as prognostic factors(P<0.05).Conclusion Donafenib combined with TACE is an effective and safe treatment option for spontaneously ruptured hepatocellular carcinoma.Furthermore,factors such as age,PVTT,Child-Pugh grade,tumor diameter,and TBIL serve as prognostic indicators for spontaneously ruptured hepatocellular carcinoma.

Objective To investigate the short-term efficacy and prognostic factors of donafenib combined with transcatheter arterial chemoembolization(TACE)in the treatment of spontaneously ruptured hepatocellular carcinoma.Methods A retrospective analysis was conducted on the data of patients diagnosed with spontaneously ruptured hepatocellular carcinoma.According to the treatment meth-ods,patients were categorized into simple group(TACE)and combined group(donafenib combined with TACE).Median progres-sion-free survival(mPFS),objective remission rate(ORR),disease control rate(DCR),and median overall survival(mOS)were calculated,and treatment-related adverse events were counted.Finally,prognostic survival factors were analyzed by Cox regression.Results The mPFS for the simple group was 4.6 months,compared to 13.6 months for the combined group(χ2=9.081,P=0.003).Similarly,the mOS for the simple group was 7.6 months,compared to 17.4 months for the combined group(χ2=6.351,P=0.012).Both mPFS and mOS were significantly lower in the simple group than those in the combined group.The ORR of 25.7%and DCR of 57.1%in the simple group were significantly lower than the ORR of 55.6%and DCR of 81.5%in the combined group,and the difference between the two groups was statistically significant(P<0.05).However,there was no statistically significant difference in the incidence of rebleeding,abdominal pain and fever between the two groups(P>0.05).Additionally,age,portal vein tumor thrombus(PVTT),Child-Pugh grade,tumor diameter,and total biliru-bin(TBIL)were identified as prognostic factors(P<0.05).Conclusion Donafenib combined with TACE is an effective and safe treatment option for spontaneously ruptured hepatocellular carcinoma.Furthermore,factors such as age,PVTT,Child-Pugh grade,tumor diameter,and TBIL serve as prognostic indicators for spontaneously ruptured hepatocellular carcinoma.