Objective:To investigate the long-term efficacy and influencing factors of transcatheter adrenal ablation in patients with primary aldosteronism (PA).Methods:This cohort study retrospectively enrolled PA patients who underwent transcatheter adrenal ablation at Daping Hospital, Army Medical University between January 2021 and December 2024. According to PASO criteria, patients were categorized into groups based on clinical outcomes (complete, partial, or no remission), biochemical outcomes (complete, partial, or no remission), and composite outcomes (complete or incomplete remission). All participants underwent 1-year follow-up, with intergroup comparisons of clinical characteristics and surgical approaches. Multivariate logistic regression models were used to identify factors influencing long-term efficacy post-transcatheter adrenal ablation in PA patients.Results:A total of 122 PA patients were enrolled, aged (47.7±11.1) years, including 55 males (45.1%). Baseline aldosterone-to-renin ratio was 0.43(0.19,0.86)(pmol·L -1)/(μU·L -1). Bilateral adrenal lesions were present in 33 cases (27.1%), while 70 (57.4%) had nodules or adenomas. Adrenal venous sampling confirmed lateralized hypersecretion in 107 patients (87.7%, left or right dominance). According to PASO criteria, 93.4% (114/122) and 95.1% (116/122) of patients achieved complete or partial remission in biochemical and clinical parameters at 1-year post-ablation, respectively. For biochemical outcomes: 40 complete, 74 partial, and 8 no remission. Patients in the partial-remission group were older than those in the no-remission group ((49.4±11.2) vs. (39.6±9.8) years), while complete-remission group had higher bilateral non-lateralized secretion rates than partial remission group (27.5% vs. 4.1%, both P<0.05). For clinical outcomes: 26 complete, 90 partial, 6 no remission. Compared to complete-remission group, partial-remission group had higher male proportion (51.1% vs. 26.9%), longer hypertension duration (4.0 (0.7, 10.0) years vs. 1.5 (0.1, 5.0) years), but lower office diastolic blood pressure ((88±11) mmHg vs. (94±12 mmHg), 1 mmHg=0.133 kPa, all P<0.05). For composite outcomes: 56 complete and 66 incomplete remission. Compared with incomplete remission group, complete remission group had lower prevalence of diabetes (8.9% vs. 22.7%) and higher proportion of bilateral non-lateralized secretion (21.4% vs. 4.6%, both P<0.05). Multivariate logistic regression identified diabetes ( OR=3.635, 95% CI 1.029-12.834, P=0.045) and lateralized secretion ( OR=9.056, 95% CI 2.039-40.212, P=0.004) as independent risk factors for poor composite outcomes after transcatheter adrenal ablation in PA patients, whereas higher office diastolic blood pressure acts as a protective factor ( OR=0.957, 95% CI 0.925-0.992, P=0.015). Conclusion:One year after transcatheter adrenal ablation, the majority of patients achieved complete or partial remission in biochemical and clinical parameters.Patients with non-lateralized adrenal hypersecretion demonstrated a higher likelihood of sustained biochemical remission and superior composite outcomes compared to those with lateralized hypersecretion.

Objective:To investigate the long-term efficacy and influencing factors of transcatheter adrenal ablation in patients with primary aldosteronism (PA).Methods:This cohort study retrospectively enrolled PA patients who underwent transcatheter adrenal ablation at Daping Hospital, Army Medical University between January 2021 and December 2024. According to PASO criteria, patients were categorized into groups based on clinical outcomes (complete, partial, or no remission), biochemical outcomes (complete, partial, or no remission), and composite outcomes (complete or incomplete remission). All participants underwent 1-year follow-up, with intergroup comparisons of clinical characteristics and surgical approaches. Multivariate logistic regression models were used to identify factors influencing long-term efficacy post-transcatheter adrenal ablation in PA patients.Results:A total of 122 PA patients were enrolled, aged (47.7±11.1) years, including 55 males (45.1%). Baseline aldosterone-to-renin ratio was 0.43(0.19,0.86)(pmol·L -1)/(μU·L -1). Bilateral adrenal lesions were present in 33 cases (27.1%), while 70 (57.4%) had nodules or adenomas. Adrenal venous sampling confirmed lateralized hypersecretion in 107 patients (87.7%, left or right dominance). According to PASO criteria, 93.4% (114/122) and 95.1% (116/122) of patients achieved complete or partial remission in biochemical and clinical parameters at 1-year post-ablation, respectively. For biochemical outcomes: 40 complete, 74 partial, and 8 no remission. Patients in the partial-remission group were older than those in the no-remission group ((49.4±11.2) vs. (39.6±9.8) years), while complete-remission group had higher bilateral non-lateralized secretion rates than partial remission group (27.5% vs. 4.1%, both P<0.05). For clinical outcomes: 26 complete, 90 partial, 6 no remission. Compared to complete-remission group, partial-remission group had higher male proportion (51.1% vs. 26.9%), longer hypertension duration (4.0 (0.7, 10.0) years vs. 1.5 (0.1, 5.0) years), but lower office diastolic blood pressure ((88±11) mmHg vs. (94±12 mmHg), 1 mmHg=0.133 kPa, all P<0.05). For composite outcomes: 56 complete and 66 incomplete remission. Compared with incomplete remission group, complete remission group had lower prevalence of diabetes (8.9% vs. 22.7%) and higher proportion of bilateral non-lateralized secretion (21.4% vs. 4.6%, both P<0.05). Multivariate logistic regression identified diabetes ( OR=3.635, 95% CI 1.029-12.834, P=0.045) and lateralized secretion ( OR=9.056, 95% CI 2.039-40.212, P=0.004) as independent risk factors for poor composite outcomes after transcatheter adrenal ablation in PA patients, whereas higher office diastolic blood pressure acts as a protective factor ( OR=0.957, 95% CI 0.925-0.992, P=0.015). Conclusion:One year after transcatheter adrenal ablation, the majority of patients achieved complete or partial remission in biochemical and clinical parameters.Patients with non-lateralized adrenal hypersecretion demonstrated a higher likelihood of sustained biochemical remission and superior composite outcomes compared to those with lateralized hypersecretion.

Branch atheromatous disease(BAD)is a common cause of ischaemic stroke.BAD-associated stroke is mild at the onset of clinical symptoms,but is prone to early neurological deterioration with fluctuating symptoms and progressive motor deficits,which often leads to poor prognosis due to lack of timely treatment.Therefore,there is an urgent need for early identification and timely intervention for BAD-related stroke.However,the pathogenesis of BAD-associated stroke has not been fully elucidated,the diagnostic tools have not been standardised,and there is a lack of strong evidence-based medical evidence for its treatment.The purpose of this article is to review the pathogenesis,diagnostic tools,complications,and treatment strategies of BAD-related stroke.

Objective To study the effect of holistic nursing intervention on thyroid cyst operation and its correlation with prognosis.Methods A total of 90 patients who underwent thyroid cyst operationin our hospital were divided into observation group and control group according to the random number table method, with 45 cases in each group.The whole nursing intervention was used in the observation group and the routine nursing intervention in the control group.The scores of anxiety and depression, postoperative pain, postoperative complications, operation time and length of stay were compared between the two groups.Results The pain rate in the observation group was significantly lower than that in the control group, the differences between the two groups were statistically significant (P<0.05).Compared with treatment before, the SAS and SDS scores of the two groups were significantly decreased after treatment, and the observation group was significantly lower than the control group, the difference between the two groups was statistically significant (P<0.05).And the time of operation and hospital stay were significantly shorter than that in the control group, the difference was statistically significant (P<0.05).The postoperative complication rate was significantly lower than that in the control group, the difference between the two groups was statistically significant (P<0.05).Conclusion Holistic nursing intervention can shorten the operation time and hospital stay of thyroid cyst, relieve anxiety and depression, reduce the pain and reduce the postoperative complications.It has a good effect on the patients'' operation and prognosis.

Objective To study the effect of holistic nursing intervention on thyroid cyst operation and its correlation with prognosis.Methods A total of 90 patients who underwent thyroid cyst operationin our hospital were divided into observation group and control group according to the random number table method, with 45 cases in each group.The whole nursing intervention was used in the observation group and the routine nursing intervention in the control group.The scores of anxiety and depression, postoperative pain, postoperative complications, operation time and length of stay were compared between the two groups.Results The pain rate in the observation group was significantly lower than that in the control group, the differences between the two groups were statistically significant (P<0.05).Compared with treatment before, the SAS and SDS scores of the two groups were significantly decreased after treatment, and the observation group was significantly lower than the control group, the difference between the two groups was statistically significant (P<0.05).And the time of operation and hospital stay were significantly shorter than that in the control group, the difference was statistically significant (P<0.05).The postoperative complication rate was significantly lower than that in the control group, the difference between the two groups was statistically significant (P<0.05).Conclusion Holistic nursing intervention can shorten the operation time and hospital stay of thyroid cyst, relieve anxiety and depression, reduce the pain and reduce the postoperative complications.It has a good effect on the patients'' operation and prognosis.