Metabolic dysfunction-associated fatty liver disease （MAFLD） is a chronic liver disease closely related to metabolic dysfunction. Its global prevalence is increasing year by year and shows a trend toward younger onset. It is closely associated with cardiovascular and cerebrovascular diseases， chronic kidney disease， and extrahepatic malignant tumors， and has become a major public health problem affecting the health of the Chinese population. At present， the treatment of MAFLD mainly focuses on lifestyle intervention. When metabolic cardiovascular risk factors and liver injury are present， pharmacological intervention is required. However， there is still no specific drug therapy for MAFLD. In recent years， many studies have found that the pathogenesis of MAFLD involves interactions among multiple factors， including insulin resistance， oxidative stress， endoplasmic reticulum stress， programmed cell death， immune dysregulation， inflammasomes， gut microbiota imbalance， and bile acid metabolism. Traditional Chinese medicine （TCM） has advantages in integrated regulation with multiple components and multiple targets， and shows significant efficacy in the treatment of MAFLD. Active components of Chinese medicinal herbs and Chinese medicine compound formulas exert definite therapeutic effects by regulating multiple signaling pathways to improve lipid metabolism disorders， inhibit inflammatory responses， and regulate the gut microbiota， thereby effectively improving clinical symptoms and delaying the occurrence and development of MAFLD. Therefore， strengthening research on the mechanisms of action of TCM in MAFLD is of crucial importance and significance for its treatment. This article summarizes the mechanisms by which Chinese medicine monomers and compound formulas intervene in MAFLD through the regulation of related signaling pathways， based on the retrieval and analysis of relevant literature from multiple databases， with the aim of providing theoretical support and a reference basis for the clinical application of TCM in the treatment of MAFLD.

Deep brain stimulation （DBS） has been widely applied in treating neurological disorders such as Parkinson’s disease， with corresponding evidence of safety and efficacy. However， when DBS is experimentally applied in the field of mental disorders， the uncertainty of its therapeutic mechanisms and targets becomes prominent， and there are peculiarities such as the lack of substantive informed consent， partial deprivation of autonomy， and the impact on the homogeneity of personality for research participants or patients. In response to the above situations， the current normative documents are still insufficient， the ethical review re-examination procedure has not yet formed a perfect system， the substantive informed consent of research participants or patients has not yet been clearly guaranteed， as well as the technical scope and regulatory boundaries are not clear. For the new application of DBS in the field of mental disorders， the principle of prudent supervision should be upheld， and appropriate regulation should be carried out to prevent the dilemma of “Collingridge”. Specifically， the ethical review system should be innovated and refined， whole-process informed consent of research participants or patients and guardian assistance in decision-making should be ensured， the legal nature of “experimental treatment” should be clarified， as well as the relevant provisions in the Mental Health Law of the People’s Republic of China should be improved， with a view to providing legal theoretical support and practical operational guidelines for the legalization and standardization of DBS’s application in mental disorder research.

Objective:To understand the current level of clinical nurses' knowledge about medical adhesive-related skin injuries (MARSI) .Methods:Using convenience sampling, 1 123 clinical nurses from the First Affiliated Hospital of Nanchang University were selected as study subjects in March 2024. A general information questionnaire and a self-designed MARSI knowledge questionnaire were used to collect data. Multiple linear regression analysis was conducted to explore the factors influencing clinical nurses' knowledge of MARSI.Results:A total of 1 200 questionnaires were distributed and 1 123 were returned, resulting in an effective response rate of 93.58%. The average score for MARSI knowledge among the 1 123 clinical nurses was (32.75±6.78) . Multiple linear regression analysis indicated that professional title, years of work experience, and whether they have received MARSI related training were the influencing factors of MARSI cognition among clinical nurses ( P<0.05) . Conclusions:Clinical nurses' knowledge of MARSI is at a low level. Managers can develop intervention strategies based on the factors influencing MARSI knowledge to improve clinical nurses' understanding of MARSI.

Objective:To understand the current level of clinical nurses' knowledge about medical adhesive-related skin injuries (MARSI) .Methods:Using convenience sampling, 1 123 clinical nurses from the First Affiliated Hospital of Nanchang University were selected as study subjects in March 2024. A general information questionnaire and a self-designed MARSI knowledge questionnaire were used to collect data. Multiple linear regression analysis was conducted to explore the factors influencing clinical nurses' knowledge of MARSI.Results:A total of 1 200 questionnaires were distributed and 1 123 were returned, resulting in an effective response rate of 93.58%. The average score for MARSI knowledge among the 1 123 clinical nurses was (32.75±6.78) . Multiple linear regression analysis indicated that professional title, years of work experience, and whether they have received MARSI related training were the influencing factors of MARSI cognition among clinical nurses ( P<0.05) . Conclusions:Clinical nurses' knowledge of MARSI is at a low level. Managers can develop intervention strategies based on the factors influencing MARSI knowledge to improve clinical nurses' understanding of MARSI.