Objective To analyze the characteristics of hematological diseases in 81 Air Force aircrews and to investigate their relation to the aviation medical evaluation. Methods Eighty-one cases of the aircrews,who were suffering from hematological diseases and were hospitalized in Air Force General Hospital from 1982 to 2010,were reviewed. The relation between hematological diseases and aviation medical evaluation was analyzed upon disease grouping. Results ① The diagnosed hematological diseases included 27 cases of leucopenia (33.3％), 16 cases of thrombocytopenia (19.8％),15 cases of anemia (18.5％),9 cases of marrow proliferating disease (11.1％),6 cases of malignant lymphoma (7.4 ％),5 cases of leukemia (6.2％) and 1 cases of malignant histocytosis,hypersplenism and necrotic lymphnoditis (1.2％ respectively).② Forty-seven aircrews were qualified for flying,including 23 cases of leucopenia,10 cases of thrombocytopenia,7 cases of anemia,4 cases of myeloproliferative disease and 3 recovered cases of malignant lymphoma.The rate of qualification was 58.0％.Five cases of acute leukemia were all grounded. Conclusions More than half aircrews with innocent hematological diseases could be qualified by proper treatment but for the aircrew with malignant hematological diseases.They still need individual evaluation and some of them would be permitted flying in case of getting satisfied treatment and recovery.

Objective To analyze the characteristics of hematological diseases in 81 Air Force aircrews and to investigate their relation to the aviation medical evaluation. Methods Eighty-one cases of the aircrews,who were suffering from hematological diseases and were hospitalized in Air Force General Hospital from 1982 to 2010,were reviewed. The relation between hematological diseases and aviation medical evaluation was analyzed upon disease grouping. Results ① The diagnosed hematological diseases included 27 cases of leucopenia (33.3％), 16 cases of thrombocytopenia (19.8％),15 cases of anemia (18.5％),9 cases of marrow proliferating disease (11.1％),6 cases of malignant lymphoma (7.4 ％),5 cases of leukemia (6.2％) and 1 cases of malignant histocytosis,hypersplenism and necrotic lymphnoditis (1.2％ respectively).② Forty-seven aircrews were qualified for flying,including 23 cases of leucopenia,10 cases of thrombocytopenia,7 cases of anemia,4 cases of myeloproliferative disease and 3 recovered cases of malignant lymphoma.The rate of qualification was 58.0％.Five cases of acute leukemia were all grounded. Conclusions More than half aircrews with innocent hematological diseases could be qualified by proper treatment but for the aircrew with malignant hematological diseases.They still need individual evaluation and some of them would be permitted flying in case of getting satisfied treatment and recovery.

Objective To understand the epidemiologic characteristics of endemic typhus in Baoshan city. Methods Epidemiological data were collected and characteristics were analyzed. IgG antibody(Ab) of Rickettsia mooseri and Orientia tsutsuganushi in serum of patients were tested using both Weil-Felix and IFA method. The Rickettsia mooseri gltA gene, Rickettsia prowazekii gltA gene,Orientia tsutsugamushi 56 kDa protein gene, SFGR ompA gene, Ehrlichia sp. 16S rRNA gene and Anaplasma sp. 16S rRNA gene in spleen of mice were examined by PCR. Results Fifty- eight endemic typhus cases were found in Longyang district of Baoshan city, during July to August, 2009.Among them, 48 cases were confirmed by clinical diagnosis and 10 cases by laboratory tests. The Ab of Orientia tsutsugamushi Karp serotype was detected in 3 cases from laboratory diagnosis. The spleen samples from 85 Rattns flavipectus were tested using PCR. Of them, 3 samples for Rickettsia mooseri gltA gene showed positive (positive rate was 3.5% ), and the homology of 3 Rickettsia mooseri and Rickettsia mooseri Wilmington strain (GenBank U59714.1) was 100% through comparing gene sequence. The results of PCR for detecting Rickettsia prowazekii, Orientia tsutsugamushi, SFGR,Anaplasma sp. and Ehrlichia. sp were all negative. Conclusion The outbreak of endemic typhus was confirmed in Longyang district of Baoshan city through epidemiological data, clinical diagnosis and laboratory tests. Rickettsia mooseri DNA was detected in the dominant Raw flavipectus, suggesting that endemic typhus did exist in the local areas.

OBJECTIVETo observe the influence of earthquake crush injury on postoperative wound healing of extremity fractures.

METHODSThe study involved 85 patients with extremities fracture underwent internal fixation operation in 3 group, including 28 earthquake casualties with crush injuries in observation group, 27 earthquake casualties without crush injuries in control I group and 30 local patients during the same period in control II group. Urine routine, blood creatine kinase (CK) and wound conditions of patients in 3 groups were observed respectively.

RESULTSThere was no significant difference in Urine routine and blood CK between 3 groups and was significant difference in wound conditions between observation group and each control group.

CONCLUSIONEarthquake crush injuries can influence the postoperative wound healing of extremity fractures.

Adult ; Aged ; Aged, 80 and over ; China ; Creatine Kinase ; blood ; Crush Syndrome ; complications ; surgery ; therapy ; Disasters ; statistics & numerical data ; Earthquakes ; Female ; Fractures, Bone ; complications ; surgery ; Humans ; Male ; Middle Aged ; Postoperative Period ; Urine ; chemistry ; Wound Healing

OBJECTIVETo investigate the enhancing effect of all-trans retinoic acid (ATRA) on the bystander effect of the herpes simplex virus thymidine kinase(HSV-TK)/ganciclovir (GCV) against androgen unresponsive prostate cancer.

METHODSThe bystander effect of the HSV-TK/GCV system was measured by methyl thiazolyl tetrazolium (MTT) assay on PC-3 cells before and after ATRA treatment. The growth and the histopathology of transplant tumors were observed in 4 groups of nude mice with prostate cancer.

RESULTSATRA augmented significantly the bystander effect of the HSV-TK/GCV system by reducing TK positive PC-3 cells from 50% to 30% (P < 0.05). HSV-TK showed an inhibiting effect, while ATRA with the HSV-TK/GCV system produced significant effect on prostate cancer 1 week earlier than the former (P < 0.05).

CONCLUSIONATRA can argument the in vivo and in vitro bystander effect of the HSV-TK/GCV system in the treatment of androgen unresponsive prostate cancer.

Animals ; Antineoplastic Agents ; pharmacology ; Bystander Effect ; drug effects ; Cell Line, Tumor ; Cell Survival ; drug effects ; Ganciclovir ; pharmacology ; Genes, Transgenic, Suicide ; genetics ; Genetic Therapy ; methods ; Humans ; Male ; Mice ; Mice, Nude ; Prostatic Neoplasms ; genetics ; pathology ; therapy ; Reverse Transcriptase Polymerase Chain Reaction ; Simplexvirus ; enzymology ; Thymidine Kinase ; genetics ; metabolism ; Tretinoin ; pharmacology ; Xenograft Model Antitumor Assays ; methods