Objective To analyze the correlation between serum oxidative stress indicators and cog-nitive dysfunction in patients with sleep disorders accompanied by anxiety and depression.Methods A total of 196 patients with sleep disorders accompanied by anxiety and depression in the hospital from A-pril 2021 to April 2023 were selected as research objects,and serum malondialdehyde(MDA),total superoxide dismutase(T-SOD),interleukin-6(IL-6)and γ-glutamyltransferase(γ-GGT)levels were measured in all the patients.Montreal Cognitive Assessment Scale(MoCA)was used to evaluate pa-tients'cognitive function,and based on MoCA score,they were divided into cognitive dysfunction group(n=80)and non-cognitive dysfunction group(n=116).Pearson correlation analysis was used to explore the correlations of serum MDA,T-SOD,IL-6 and γ-GGT levels with Pittsburgh Sleep Quali-ty Index(PSQI)score.Spearman rank correlation analysis was used to explore the correlations of ser-um MDA,T-SOD,IL-6 and γ-GGT levels with cognitive dysfunction in patients with sleep disorders accompanied by anxiety and depression.Receiver operating characteristic(ROC)curve was used to evaluate the values of serum MDA,T-SOD,IL-6 and γ-GGT in assessing cognitive dysfunction in patients with sleep disorders accompanied by anxiety and depression.Results Serum MDA,IL-6 and γ-GGT levels as well as PSQI score were significantly higher in the cognitive dysfunction group than those in the non-cognitive dysfunction group,while the T-SOD level was significantly lower in the cognitive dysfunction group(P＜0.05).Pearson correlation analysis results showed that serum MDA,IL-6 and γ-GGT levels were positively correlated with PSQI score(r=0.128,r=0.317,r=0.261,P=0.037,P＜0.001,P＜0.001,respectively),while serum T-SOD level was nega-tively correlated with PSQI score(r=-0.145,P=0.021).Spearman rank correlation analysis re-sults showed that serum MDA,IL-6 and γ-GGT levels were positively correlated with the occurrence of cognitive dysfunction(r=0.322,0.554,0.441,P＜0.001),while serum T-SOD level was negatively correlated with the occurrence of cognitive dysfunction(r=-0.330,P＜0.001).ROC curve analysis results showed that the areas under the curve(AUCs)for the individual and com-bined assessment of serum MDA,T-SOD,IL-6 and γ-GGT in patients with sleep disorders accompa-nied by anxiety and depression for cognitive dysfunction were 0.689,0.694,0.825,0.759 and 0.955 respectively,with cut-off values of 9.6 mmol/L,71.6 U/L,5.2 μg/L and 48.8 U/L,sen-sitivities of 50.00％,77.50％,71.25％,73.75％and 91.25％respectively,and specificities of 84.48％,62.93％,81.90％,70.69％and 88.79％respectively.Conclusion Cognitive dys-function in patients with sleep disorders accompanied by anxiety and depression is closely related to serum MDA,T-SOD,IL-6 and γ-GGT,and early measurement of these indicators can provide a ref-erence for the clinical assessment of cognitive dysfunction.