Objective To explore the application value of triggered angiography non-contrast enhanced (TRANCE) technology in diagnosing lower limb arterial occlusive disease.Methods Totally 22 lower limb arterial occlusive disease patients were randomly selected,and then underwent TRANCE and DSA examinations.The arteries from the abdomen to the lower limb were divided into abdominal aorta,common iliac artery,external iliac artery,internal iliac artery,superficial femoral artery,deep femoral artery,popliteal artery,anterior tibial artery,posterior tibial artery and peroneal artery.Totally 337 sections displayed clearly were chosen to go through examinations by TRANCE and DSA.Results Of the 337 sections there were 312 ones with the same stenoses found by TRANCE and DSA,TRANCE found 16 sections with worse stenoses and 9 milder ones than by DSA.There were 153 sections with the same moderate stenoses (≥50％) displayed by TRANCE and DSA;Of the 153 sections,there were 15 ones with worse stenoses and 6 ones with milder stenoses found by TRANCE than by DSA.Kappa value of the two methods was 0.905.Conclusion TRANCE technology is a non-invasive,safe and nonradiative diagnosing method for the lower limb arterial occlusive disease.

Objective To investigate the research progress of hepatotoxicity due to antifungal drugs, in order to provide a reference for clinical safety use of antifungal drugs. Methods "Antifungal drugs" and"hepatotoxicity" were selected as the keywords,and PubMed,Embase,Web of Science,Chinese Academic Periodical Full-text Database China HowNet Chinese Academic Journal( CNKI ) and Chinese Biomedical Literature database( CBMdisc)were searched. All literature on hepatotoxicity due to antifungal drugs were selected. A database of literature accepted for final bibliometric study was established by using Microsoft Excel. The parameters of bibliometrics such as published time( years),the top 5 countries and institutes in publishing,literature′s type,published time( years),top 5 journals in publishing number,top 10 articles in terms of cited frequency were studied. The main content and hotspot of literature were analyzed. The clinical manifestations, mechanism, incidence and prophylactico-therapeutic measures of hepatotoxicity due to antifungal drugs were summarized. Results A total of 221 articals(193 in English,28 in Chinese)were enrolled in the study,of which 116 were original articles,49 reviews and 56 case reports. The published time of first original publication of hepatotoxicity due to antifungal drugs were 1976. The journal which published largest number of articles was Mycoses. The highest citation number of individual article was 531. The main clinical manifestations were weak,right upper quadrant pain,diarrhea,jaundice,cholestasis and fever. The severe cases could cause liver failure. Laboratory examination showed elevated serum transaminases,bilirubin, and alkaline phosphatase. The incidence of liver toxicity due to azole antifungals was higher,the incidence of liver toxicity due to amphotericin B was lower. The antifungal drugs should be used with caution in patients with hypohepatia. For the patients who used antifungal drugs for long time,the liver function should be monitored regularly. If liver injury occurs,the antifungal drugs should be stopped immediately. Some patients′liver function test results could return to the normal levels before administration of the symptomatic treatment and the supportive liver protection therapy. The mechanism of hepatotoxicity due to antifungal drugs was unknown,it may be related to the damage of cytoplasmic membrane structure and inhibition of metabolism in cytochrome P450 2D6 enzyme. Conclusions The research abroad on hepatotoxicity due to antifungal drugs are ahead of China. Hepatotoxicity due to antifungal drugs is partially reversible.

Objective To investigate the research progress of hepatotoxicity due to antifungal drugs, in order to provide a reference for clinical safety use of antifungal drugs. Methods "Antifungal drugs" and"hepatotoxicity" were selected as the keywords,and PubMed,Embase,Web of Science,Chinese Academic Periodical Full-text Database China HowNet Chinese Academic Journal( CNKI ) and Chinese Biomedical Literature database( CBMdisc)were searched. All literature on hepatotoxicity due to antifungal drugs were selected. A database of literature accepted for final bibliometric study was established by using Microsoft Excel. The parameters of bibliometrics such as published time( years),the top 5 countries and institutes in publishing,literature′s type,published time( years),top 5 journals in publishing number,top 10 articles in terms of cited frequency were studied. The main content and hotspot of literature were analyzed. The clinical manifestations, mechanism, incidence and prophylactico-therapeutic measures of hepatotoxicity due to antifungal drugs were summarized. Results A total of 221 articals(193 in English,28 in Chinese)were enrolled in the study,of which 116 were original articles,49 reviews and 56 case reports. The published time of first original publication of hepatotoxicity due to antifungal drugs were 1976. The journal which published largest number of articles was Mycoses. The highest citation number of individual article was 531. The main clinical manifestations were weak,right upper quadrant pain,diarrhea,jaundice,cholestasis and fever. The severe cases could cause liver failure. Laboratory examination showed elevated serum transaminases,bilirubin, and alkaline phosphatase. The incidence of liver toxicity due to azole antifungals was higher,the incidence of liver toxicity due to amphotericin B was lower. The antifungal drugs should be used with caution in patients with hypohepatia. For the patients who used antifungal drugs for long time,the liver function should be monitored regularly. If liver injury occurs,the antifungal drugs should be stopped immediately. Some patients′liver function test results could return to the normal levels before administration of the symptomatic treatment and the supportive liver protection therapy. The mechanism of hepatotoxicity due to antifungal drugs was unknown,it may be related to the damage of cytoplasmic membrane structure and inhibition of metabolism in cytochrome P450 2D6 enzyme. Conclusions The research abroad on hepatotoxicity due to antifungal drugs are ahead of China. Hepatotoxicity due to antifungal drugs is partially reversible.