Objective:To analyze the risk factors for cervical lymph node metastasis and lateral cervical lymph node metastasis, and to explore the role of serum calcitonin(Ctn) and carcinoembryonic antigen(CEA) levels in predicting lymph node metastasis in patients of medullary thyroid carcinoma(MTC).Methods:A retrospective analysis was conducted on the clinical data of 82 MTC patients who underwent primary surgery at Jiangsu Provincial People's Hospital from Nov 2016 to Mar 2024. A multivariate Logistic regression model was constructed to evaluate the association between each predictor and the outcome variable by using the least absolute shrinkage and selection operator (LASSO).Results:LASSO Logistic regression analysis showed that male gender ( OR=2.84,95% CI:1.14-2.38, P=0.065)、serum LnCEA( OR=1.64,95% CI:1.13-2.38, P=0.008)、serum LnCtn( OR=1.41,95% CI:1.01-1.97, P=0.043) were independent influencing factors for cervical lymph node metastasis in MTC. Based on the LASSO-built Logistic regression model, the model had the highest predictive value when female gender, serum CEA≈15.03 ng/ml, serum Ctn≈41.6 pg/ml. The predictive sensitivity was 0.727 (95% CI: 0.618-0.836), specificity was 0.852 (95% CI: 0.704-0.963). Further subgroup analysis for lateral cervical lymph node metastasis showed that in the LASSO-built logistic regression model, when serum CEA≈16.1 ng/ml, and central lymph node metastasis was negative, the predicted sensitivity and specificity were 0.810 and 0.700, respectively. Prognostic analysis revealed that age, Ctn and thyroid stimulating hormone were the influencing factors of the prognosis of MTC. Conclusions:When male gender, serum CEA>15.03 ng/ml and serum Ctn>41.6 pg/ml are met simultaneously in MTC patients, the possibility of cervical lymph node metastasis is the greatest. It is recommended to perform preventive lateral cervical lymph node dissection for MTC patients who has CEA>16.1 ng/ml and LN1a positive at the same time.

Objective:To analyze the risk factors for cervical lymph node metastasis and lateral cervical lymph node metastasis, and to explore the role of serum calcitonin(Ctn) and carcinoembryonic antigen(CEA) levels in predicting lymph node metastasis in patients of medullary thyroid carcinoma(MTC).Methods:A retrospective analysis was conducted on the clinical data of 82 MTC patients who underwent primary surgery at Jiangsu Provincial People's Hospital from Nov 2016 to Mar 2024. A multivariate Logistic regression model was constructed to evaluate the association between each predictor and the outcome variable by using the least absolute shrinkage and selection operator (LASSO).Results:LASSO Logistic regression analysis showed that male gender ( OR=2.84,95% CI:1.14-2.38, P=0.065)、serum LnCEA( OR=1.64,95% CI:1.13-2.38, P=0.008)、serum LnCtn( OR=1.41,95% CI:1.01-1.97, P=0.043) were independent influencing factors for cervical lymph node metastasis in MTC. Based on the LASSO-built Logistic regression model, the model had the highest predictive value when female gender, serum CEA≈15.03 ng/ml, serum Ctn≈41.6 pg/ml. The predictive sensitivity was 0.727 (95% CI: 0.618-0.836), specificity was 0.852 (95% CI: 0.704-0.963). Further subgroup analysis for lateral cervical lymph node metastasis showed that in the LASSO-built logistic regression model, when serum CEA≈16.1 ng/ml, and central lymph node metastasis was negative, the predicted sensitivity and specificity were 0.810 and 0.700, respectively. Prognostic analysis revealed that age, Ctn and thyroid stimulating hormone were the influencing factors of the prognosis of MTC. Conclusions:When male gender, serum CEA>15.03 ng/ml and serum Ctn>41.6 pg/ml are met simultaneously in MTC patients, the possibility of cervical lymph node metastasis is the greatest. It is recommended to perform preventive lateral cervical lymph node dissection for MTC patients who has CEA>16.1 ng/ml and LN1a positive at the same time.

BACKGROUND: A few devices have been reported to be used for studies on trauma, but these devices are unavailable for establishing the animal models of trauma because of their limited application range. OBJECTIVE: To develop a multifunctional impact system and evaluate its application effect, thus paying ways for establishing the animal models of trauma and basic experiments.METHODS: The multifunctional impact system was designed based on the theory of energy storage device, simple multifunctional impact device and impact parameter measuring equipment, and its effectiveness and stability were detected. The rat chest and different visceral organs were subjected to the closed impact experiment using a 5 cm2 impact at the predetermined parameter of 200, 300, 400, 500 kPa, respectively. Afterwards, the rats were sacrificed for morphological observation.RESULTS AND CONCLUSION: The multifunctional impactor was successfully developed, of which the maximum impact stress could be adjusted from 0 to 200 kg and compressive and extrusion stress also could be continuously adjusted from 0 to 100 kg. The experimental results showed that the impactor made certain damage to the rat lung, liver and spleen suggesting its favorable effectiveness (P < 0.05) and repeatability (P > 0.05). These findings suggest that the impactor is easy to operate in various ways and holds good effectiveness and stability, and its impact parameters can be detected in real time. Therefore, the impactor is suitable for both establishing the animal model of trauma and basic experiments.