Breast cancer is the most common malignant tumor among women worldwide. Endocrine therapy is one of the important adjuvant treatment modalities, which can effectively reduce the mortality and the risk of recurrence, but at the same time patients suffer from the distress caused by treatment-related symptom clusters. Symptom clusters severely affect patients' quality of life and treatment adherence. This paper reviews the endocrine therapy-related symptom clusters and their management in breast cancer patients at home and abroad, and describes the concepts, occurrence mechanisms, theoretical models, assessment tools and management strategies of symptom clusters, with a view to providing references for the scientific management and research of endocrine therapy-related symptom clusters of breast cancer.

Breast cancer is the most common malignant tumor among women worldwide. Endocrine therapy is one of the important adjuvant treatment modalities, which can effectively reduce the mortality and the risk of recurrence, but at the same time patients suffer from the distress caused by treatment-related symptom clusters. Symptom clusters severely affect patients' quality of life and treatment adherence. This paper reviews the endocrine therapy-related symptom clusters and their management in breast cancer patients at home and abroad, and describes the concepts, occurrence mechanisms, theoretical models, assessment tools and management strategies of symptom clusters, with a view to providing references for the scientific management and research of endocrine therapy-related symptom clusters of breast cancer.