Meditation aims to guide individuals into a state of deep calm and focused attention, and in recent years, it has shown promising potential in the field of medical treatment. Numerous studies have demonstrated that electroencephalogram (EEG) patterns change during meditation, suggesting the feasibility of using deep learning techniques to monitor meditation states. However, significant inter-subject differences in EEG signals poses challenges to the performance of such monitoring systems. To address this issue, this study proposed a novel model-calibrated multi-source adversarial adaptation network (CMAAN). The model first trained multiple domain-adversarial neural networks in a pairwise manner between various source-domain individuals and the target-domain individual. These networks were then integrated through a calibration process using a small amount of labeled data from the target domain to enhance performance. We evaluated the proposed model on an EEG dataset collected from 18 subjects undergoing methamphetamine rehabilitation. The model achieved a classification accuracy of 73.09%. Additionally, based on the learned model, we analyzed the key EEG frequency bands and brain regions involved in the meditation process. The proposed multi-source domain adaptation framework improves both the performance and robustness of EEG-based meditation monitoring and holds great promise for applications in biomedical informatics and clinical practice.
Humans ; Electroencephalography/methods* ; Meditation ; Calibration ; Neural Networks, Computer ; Brain/physiology* ; Rest/physiology* ; Deep Learning ; Signal Processing, Computer-Assisted

Objective To observe the effect of Tongyang-Kuanxiong guanule combined with conventional western medicine for the stable angina pectoris (SAP) with qi and phlegm and blood stasis syndrome. Methods Eighty-six SAP patients who met the inclusion criteria were randomly divided into two groups according to the digital table method, with 43 cases in each group. The control group was treated with routine Western medical therapy. The observation group was given Tongyang-Kuanxiong guanule on the basis of the control group. Both groups were treated for 28 days. The TCM syndromes and angina pectoris scores were evaluated before and after treatment. The treadmill exercise test was used to observe the duration of exercise, the metabolic equivalent, the maximum value of ST segment depression, the heart rate at maximum load, the duration of ST segment depression. And the adverse reactions were recorded. Results The total effective rate was 88.4％ (38/43) in the observation group and 67.4％ (29/43) in the control group. The difference between the two groups was statistically significant (χ2=5.549, P=0.018). After treatment, the duration of exercise (9.5 ± 1.2 min vs. 8.6 ± 1.2 min, t=3.371), metabolic equivalent (10.8 ± 2.5 METs vs. 9.2 ± 2.4 METs, t=3.084) in the observation group were significantly higher than those in the control group (P<0.01 or P<0.05). The largest degree of ST segment changes (1.2 ± 0.6 mV vs. 1.9 ± 0.6 mV, t=5.484), and the duration of ST segment descent (125.0 ± 94.5 s vs. 162.4 ± 96.9 s, t=1.795) in the observation group were significantly lower than those in the control group (P<0.01 or P<0.05). Thefrequency of angina attacks (9.7 ± 1.6 times per week vs. 17.3 ± 2.1 times per week, t=18.778), duration of attacks (3.2 ± 1.4 min vs. 6.4 ± 1.5 min, t=10.146) consumption of nitroglycerin (1.3 ± 0.8 mg vs. 2.5 ± 0.8 mg, t=7.624) and Symptom score (8.3 ± 2.8 vs. 12.5 ± 3.1, t=6.593) in the observation group were significantly lower than the control group (P<0.01). Conclusions The Tongyang-Kuanxiong guanule can significantly improve the exercise tolerance of SAP patients with qi and phlegm and blood stasis, reduce myocardial oxygen consumption, improve angina pectoris and reduce the number of angina attacks.

OBJECTIVE:To provide reference for the rational use of antibiotics in outpatients who had genital tract Mycoplas-ma infections in Yulin area. METHODS:Using the integration culture plate,19 836 outpatient's specimens with suspected Myco-plasma infection from Yulin Maternal and Child Health Care Hospital during 2012 to 2014 were tested,and then the results of drug susceptibility test were retrospectively analyzed. RESULTS:In the total of 19 836 inspected specimens,5 640 cases were positive with the rate of 28.4%. The positive rate of Ureaplasma urealyticum(Uu),Mycoplasma hominis(Mh),mixed(Uu+ Mh)infection were 88.0%,3.8% and 8.2% respectively. The positive rate of male patient with Mycoplasma infection was lower than female pa-tient(P<0.05). Male and female patients with positive maximum age respectively at the age of 25 to 40 (81.3%) and 20 to 35 years old(78.6%). From 2012 to 2014,Mycoplasma showed different degree of drug resistance to 9 kinds of antibiotics. In gener-al,the resistance rate of Uu to lincocin was close to 100%,Mh to erythromycin,roxithromycin and azithromycin were higher than 70%,and those of Uu+Mh were lower than 10% only to josamcine,minocycline and doxycycline. CONCLUSIONS:During 2012 to 2014,the rate of genital tract Mycoplasma infection in male and female outpatients of Yulin region increased year by year,and the infection mainly caused by Uu with a serious drug resistance. We should also pay attentions to the increase of Mh infection and mixed infection. Josamycin,minocycline and doxcycline can be used as a drug choice for empiric preferred treatment,and other an-tibiotics should be used based on antibiotics susceptibility test results.