As rotator cuff injury is highly prevalent among the elderly, it significantly affects their daily life and financial status. Moreover, a high prevalence of osteoporosis in the aging population is a significant challenge to the repair and healing of the injury. Surgeons have attempted to enhance the initial fixation strength of anchors and local bone quality in recent years, but effective repair of rotator cuff injury in combination with osteoporosis remains a difficult problem. Therefore, researchers are exploring to enhance the fixation strength of anchor nails to diminish the need for surgical revisions. This article examines the relationship between osteoporosis and rotator cuff injury, the impact of osteoporosis on treatment outcomes, and current measures to improve the situation, hoping to help clinicians with reference information to achieve their treatment objectives and maximize patient satisfaction.

As rotator cuff injury is highly prevalent among the elderly, it significantly affects their daily life and financial status. Moreover, a high prevalence of osteoporosis in the aging population is a significant challenge to the repair and healing of the injury. Surgeons have attempted to enhance the initial fixation strength of anchors and local bone quality in recent years, but effective repair of rotator cuff injury in combination with osteoporosis remains a difficult problem. Therefore, researchers are exploring to enhance the fixation strength of anchor nails to diminish the need for surgical revisions. This article examines the relationship between osteoporosis and rotator cuff injury, the impact of osteoporosis on treatment outcomes, and current measures to improve the situation, hoping to help clinicians with reference information to achieve their treatment objectives and maximize patient satisfaction.

OBJECTIVE: To investigate the ubiquitin expression in laryngeal squamous cell carcinoma (LSCC) whether along with local lymph node metastasis, and further study its correlation with local lymph node metastasis and other clinicopathological parameters in laryngeal squamous cell carcinoma. METHOD: We detected the different expression level of ubiquitin in paraffin specimens between 19 cases of LSCC associated with cervical lymph node metastasis LSCC(N+) and 20 cases of LSCC not associated with cervical lymph node metastasis LSCC(N-) by immunohistochemical staining combined with stereology image analysis system. Statistics were analyzed by student test, variance analysis and ROC curve. RESULT: Ubiquitin expression in LSCC(N+) was significantly higher than LSCC(N-) (P < 0.01); their expression level was not correlated with age,history of tobacco, alcohol addiction, clinical stage and primary site,etc. CONCLUSION Ubiquitin was significantly up-expressed in LSCC(N+) than ILSCC (N-), which may imply that it is one of the important elements in mechanism of lymph node metastasis in LSCC.
Adult ; Aged ; Carcinoma, Squamous Cell ; metabolism ; pathology ; Female ; Head and Neck Neoplasms ; metabolism ; pathology ; Humans ; Laryngeal Neoplasms ; metabolism ; pathology ; Lymph Nodes ; pathology ; Lymphatic Metastasis ; Male ; Middle Aged ; Squamous Cell Carcinoma of Head and Neck ; Ubiquitin ; metabolism