Cerebral ischemia reperfusion injury(CIRI)is a secondary brain injury that may occur in patients with ischemic stroke during the process of blood flow recovery.NOD-like receptor protein 3(NLRP3)inflammasome plays an important role in the occurrence and development of CIRI.Regulating the activity of NLRP3 inflammasome can induce cell pyroptosis,induce neuroinflammatory response,promote macrophage/microglial polarization,destroy the blood-brain barrier,affect angiogenesis and neurogenesis,thereby affecting CIRI.Traditional Chinese medicine has obvious advantages in the treatment of CIRI.In this paper,with NLRP3 inflammasome as the core,we systematically elucidated the mechanism of action of traditional Chinese medicines on CIRI,and found that traditional Chinese medicines monomers(such as baicalin,polygalasaponin F)and traditional Chinese medicines compound formulas(such as Huangqi guizhi wuwu decoction,Yiqi shengqing formulation)can inhibit NLRP3 inflammasome activity,reduce inflammatory response and oxidative stress,and improve neuronal injury,thereby reducing CIRI.

Cerebral ischemia-reperfusion injury(CIR1)refers to the recovery of blood supply after cerebral ischemia,which leads to further damage and the dysfunction of brain tissue.Modern medicine has made some progress in the prevention and treatment of CIRI,but it still faces some challenges and limitations.Therefore,it is of great clinical value to find effective interventions to prevent and treat CIRI.AMP-activated protein kinase(AMPK)and its downstream proteins are important targets for the treatment of CIRI and play key roles in the regulation of cellular energy homeostasis.Traditional Chinese medicine for CIRI has multi-target and multi-pathway activities and multiple effects.It can activate a cascade of reactions in the AMPK signaling pathway and can be used to treat CIRI by regulating autophagy,oxidative stress,inflammatory response,and apoptosis,and has achieved certain result.Therefore,this paper summarizes the structure and mechanisms of the AMPK-related signaling pathway,elaborates on its relationship with CIRI,and systematically summarizes the research status of traditional Chinese medicine's ability to regulate the AMPK signaling pathway in the prevention and treatment of CIRI.This paper aims to provide new ideas for the prevention and treatment of CIRI using traditional Chinese medicine and the development of new drugs.

Stroke is a disease that seriously threatens human health.Traditional Chinese medicine believes that turbid phlegm and sthenia fever are common pathological factors of stroke.The early diagnosis of stroke usually depends on advanced imaging techniques,such as MRI and CT,and there is still a lack of diagnostic biomarkers.Therefore,exploring the biological markers of Phlegm-Heat and Bowel-Excess Syndrome of stroke,combining macro-dialectics with micro-dialectics,can provide objective data support for the prevention and treatment of stroke by traditional Chinese medicine,which is of great significance for the diagnosis,treatment and prognosis evaluation of stroke.This paper reviews and summarizes the clinical biochemical indicators,microbiome,genomics,transcriptomics,proteomics,metabolomics and other aspects,aiming to find specific biomarkers related to Phlegm-Heat and Bowel-Excess Syndrome of stroke,so as to provide molecular basis for the objective research system of stroke"syndrome"and new ideas for the study of syndrome essence.

Stroke is a disease that seriously threatens human health.Traditional Chinese medicine believes that turbid phlegm and sthenia fever are common pathological factors of stroke.The early diagnosis of stroke usually depends on advanced imaging techniques,such as MRI and CT,and there is still a lack of diagnostic biomarkers.Therefore,exploring the biological markers of Phlegm-Heat and Bowel-Excess Syndrome of stroke,combining macro-dialectics with micro-dialectics,can provide objective data support for the prevention and treatment of stroke by traditional Chinese medicine,which is of great significance for the diagnosis,treatment and prognosis evaluation of stroke.This paper reviews and summarizes the clinical biochemical indicators,microbiome,genomics,transcriptomics,proteomics,metabolomics and other aspects,aiming to find specific biomarkers related to Phlegm-Heat and Bowel-Excess Syndrome of stroke,so as to provide molecular basis for the objective research system of stroke"syndrome"and new ideas for the study of syndrome essence.