Objective To explore the effect of transcranial direct current stimulation(tDCS)in rehabilitation of swallowing function in stroke patients.Methods A total of 86 stroke patients diagnosed and treated in Affiliated Rehabilitation Hospital of Zhejiang Chinese Medical University from December 2022 to December 2023 were selected as study objects,and they were divided into observation group and control group according to random number table method,with 43 cases in each group.The control group received routine rehabilitation programs,while the observation group received tDCS therapy on the basis of control group.The swallowing function,actual swallowing process and quality of life of two groups were compared before and after intervention.Results After the intervention,standardized swallowing assessment scores of observation group were significantly lower than those of control group(P＜0.05).The scores of oral and pharyngeal phases of observation group were higher than those of control group(P＜0.05),and there was no significant difference in esophageal phase score between two groups(P＞0.05).The quality of life score of observation group was significantly higher than that of control group(P＜0.05).Conclusion tDCS can improve the swallowing function of stroke patients and improve the quality of life,which is worthy of clinical application.

Objective To explore the effect of transcranial direct current stimulation(tDCS)in rehabilitation of swallowing function in stroke patients.Methods A total of 86 stroke patients diagnosed and treated in Affiliated Rehabilitation Hospital of Zhejiang Chinese Medical University from December 2022 to December 2023 were selected as study objects,and they were divided into observation group and control group according to random number table method,with 43 cases in each group.The control group received routine rehabilitation programs,while the observation group received tDCS therapy on the basis of control group.The swallowing function,actual swallowing process and quality of life of two groups were compared before and after intervention.Results After the intervention,standardized swallowing assessment scores of observation group were significantly lower than those of control group(P＜0.05).The scores of oral and pharyngeal phases of observation group were higher than those of control group(P＜0.05),and there was no significant difference in esophageal phase score between two groups(P＞0.05).The quality of life score of observation group was significantly higher than that of control group(P＜0.05).Conclusion tDCS can improve the swallowing function of stroke patients and improve the quality of life,which is worthy of clinical application.

CRISPR/Cas system, an adaptive immune system with clustered regularly interspaced short palindromic repeats, may interfere with exogenous nucleic acids and protect prokaryotes from external damages, is an effective gene editing and nucleic acid detection tools. The CRISPR/Cas system has been widely applied in virology and bacteriology; however, there is relatively less knowledge about the application of the CRISPR/Cas system in parasitic diseases. The review summarizes the mechanisms of action of the CRISPR/Cas system and provides a comprehensive overview of their application in gene editing and nucleic acid detection of parasitic diseases, so as to provide insights into future studies on parasitic diseases.

A total of 560 patients with primary hypertension were divided into two groups.Of them,260 were treated with Fosinopril(10～20 mg once daily),and the other 300 were treated with Amlodipine (5～10 mg once daily).The treatment lasted for 12 months in both groups.The levels of blood pressure (BP)、braehial ankle pulse wave velocity(baPWV)and pulse pressure(PP)were examined at baseline,6 month and 12 month with automatic analysis system of arteriosclerosis.BP in Amlodipine group(132/76 mm Hg)decreased more significantly than Fosinopril group(136/85 mm Hg),but Fosinopril group showed more remarkable changes in baPWV(1310 cm/s)and PP(52 mm Hg)than Amlodipine group(1400 cm/s and 56 mm Hg).