Objective To explore the imaging characteristics of lung cancers associated with cystic airspaces (LCCA) and the effects of different treatment regimens. Methods A retrospective analysis was conducted on the clinical and radiological data of LCCA patients who underwent surgical resection and pathological confirmation at the Department of Thoracic Surgery, the First Affiliated Hospital of Soochow University from 2016 to 2023. The relationship between various radiological classifications and clinical pathology was studied. Based on the postoperative adjuvant treatment follow-up results, the effects of different treatment regimens were analyzed. Results A total of 147 patients were included, including 90 males and 57 females, with a median age of 63 (55, 70) years. There were 21 patients of imaging typeⅠ, 50 patients of typeⅡ, 57 patients of type Ⅲ, and 19 patients of type Ⅳ. The lobulation sign or burr sign of typeⅠcyst walls (P=0.004), and intracystic septa (P=0.030) were more commonly seen in the high-aggressiveness group. The components of the cyst walls or nodules of types Ⅰ-Ⅳ in the high-aggressiveness group were mostly solid or sub-solid (P<0.05). Multivariate logistic regression analysis indicated that subsolid cyst wall (OR=4.734, P=0.023), solid cyst wall (OR=97.972, P<0.001), and the lobulation sign or burr sign of the cyst wall (OR=13.215, P=0.024) were independent risk factors for aggressiveness. Fifty-eight patients received adjuvant therapy after surgery, including 22 in the chemotherapy group, 15 in the targeted therapy group, and 21 in the combined therapy group. The progression-free survival of the combined therapy group was better than the other two groups (P=0.045). Conclusion There is a correlation between the imaging features of LCCA and pathological aggressiveness. Compared to postoperative targeted therapy or chemotherapy alone, postoperative chemotherapy combined with targeted therapy can improve the progression-free survival of LCCA patients.

To investigate the association between sleep-related phenotypes and the risk of malignancy in pulmonary nodules, and to provide complementary evidence from a general population cohort and genetic analyses.

Objective:To construct a risk prediction model based on explainable intelligence(XAI)analysis algorithms for orthopedic consumables in surgery room,and improve the management quality of controlling risk for orthopedic consumables in surgery room.Methods:A risk index system for orthopedic consumables in the surgery room was established through researching literature and using Delphi method.The data of supply and use of consumables were collected to construct a risk prediction model.Risk control paths were formulated from three aspects included formulating preoperative plan,intraoperative dynamic allocation,and postoperative tracking and feedback.A total of 6,572 sets of orthopedic consumables that were used in the surgery room of the 960th Hospital of People's Liberation Army Joint Service Support Force from January 2021 to December 2024 were selected.The 3,185 sets of orthopedic consumables that were used during January 2021 and December 2022 were managed by using conventional method of controlling and managing risk.The 3,387 sets of orthopedic consumables that were used during January 2023 and December 2024 were managed by using intelligent method of controlling and managing risk.The early warning capabilities for risk,and the control quality for risk between the two management methods were compared.A self-made satisfaction survey questionnaire was adopted to investigate the satisfaction scores of medical staffs and managers for consumables in the surgery room for the two management methods.Results:The average accuracy rates of using the intelligent method of controlling and managing risk in predicting formulating preoperative plan,intraoperatively dynamic allocation,and postoperative tracking and feedback for early warning events of risk in 157,247 and 57 consumables were respectively 49.68%(78/157),42.11%(104/247)and 56.14%(32/57),all of which were higher than those of conventional method of controlling and managing risk,and the difference were statistically significant(x2=9.475,23.637,13.035,P<0.05).The average reduction rate of risk events of consumables,the average intervention rate of abnormal use of consumables,and the mean value of enhance degree of turnover efficiency of consumables were respectively(6.25±1.59)%,(87.93±4.44)%and(4.78±1.69)%,all of which were higher than those of conventional method of controlling and managing risk,and the differences were statistically significant(t=4.952,6.257,4.660,P<0.05).The scores of medical staffs and managers in surgery room for acceptance of early warning for risk,support of management decision,satisfaction of using consumables,and assessment results of training by adopting intelligent method of controlling and managing risk were all higher than those by adopting conventional method of controlling and managing risk,and the differences were statistically significant(t=3.368,3.082,3.701,4.558,P<0.05).Conclusion:The application of prediction model based on XAI analysis algorithm for risk of orthopedic consumables in the surgery room can improve the accuracy of early warning for risk of orthopedic consumables in the surgery room,and reduce the incidence of risk events,and enhance the ability of emergent response for risk,and improve the quality of clinical services.

Objective:To investigate the essential determinants that are critical to initiating the assembly of outer membrane proteins by replacing the POTRA domains of the translocator protein FhaC and the insertase protein TtOmp85 of the Omp85 family. Methods:FhaC, TtOmp85 proteins and their recombinant chimeric proteins after replacing the POTRA domain were obtained by overexpression and purification in vitro. An in vitro reconstitution system was used to investigate the effects of the different domains on the transport efficiency of the substrate outer membrane protein FhaB and the membrane insertion efficiency of OmpA. Results:Replacing the POTRA domain of FhaC with that of TtOmp85 led to the loss of the transport function of FhaB. During the membrane insertion process of OmpA, the FhaC mutant containing the POTRA of TtOmp85 protein acquired the ability to assemble OmpA. Conclusion:The compositional differences in the POTRA domain of Omp85 family proteins determine their abilities to recognize their substrate proteins.

[Objective]To systematically sort out the theoretical basis of the concept of"cooked chewing"eating health preservation in traditional Chinese medicine(TCM)and Taoist literature,explain its specific practical methods,provide theoretical basis and operational guidelines for contemporary health preservation practice.[Methods]Based on the research method of philology,this paper systematically analyzed the bamboo and silk classics of Han Dynasty and the medical classics handed down from ancient times such as Huangdi Neijing,Yangxing Yanminglu,Qianjin Yaofang,combined with the Taoist health preservation literature contained in Daozang,and used the basic theory of TCM and Taoist health preservation theory to theoretically explain the health preservation method of"cooked chewing".[Results]It reveals that the health preservation method of"cooked chewing"is based on the theory of Taoist knocking teeth.The method of producing body fluid by knocking teeth up and down is related to the relationship between kidney saliva,spleen saliva and kidney teeth in the theory of TCM,and then sums up the specific operation specifications such as"cooked chewing should be closed to the genus of Zhongqing Tiangu"and"cooked chewing should be up to thirty-six times".[Conclusion]As a kind of health preservation method derived from knocking teeth,"cooked chewing"transforms the complex knocking teeth of Taoism into simple chewing behavior.The concept of health preservation contained in it is of great significance to the practice of contemporary health preservation.

[Objective]To systematically sort out the theoretical basis of the concept of"cooked chewing"eating health preservation in traditional Chinese medicine(TCM)and Taoist literature,explain its specific practical methods,provide theoretical basis and operational guidelines for contemporary health preservation practice.[Methods]Based on the research method of philology,this paper systematically analyzed the bamboo and silk classics of Han Dynasty and the medical classics handed down from ancient times such as Huangdi Neijing,Yangxing Yanminglu,Qianjin Yaofang,combined with the Taoist health preservation literature contained in Daozang,and used the basic theory of TCM and Taoist health preservation theory to theoretically explain the health preservation method of"cooked chewing".[Results]It reveals that the health preservation method of"cooked chewing"is based on the theory of Taoist knocking teeth.The method of producing body fluid by knocking teeth up and down is related to the relationship between kidney saliva,spleen saliva and kidney teeth in the theory of TCM,and then sums up the specific operation specifications such as"cooked chewing should be closed to the genus of Zhongqing Tiangu"and"cooked chewing should be up to thirty-six times".[Conclusion]As a kind of health preservation method derived from knocking teeth,"cooked chewing"transforms the complex knocking teeth of Taoism into simple chewing behavior.The concept of health preservation contained in it is of great significance to the practice of contemporary health preservation.

Objective:To investigate the characteristics of Internet addiction(IA)in adolescents with depression and explore its relationship with impulsivity and aggressive personality traits.Methods:A total of 71 adolescent patients with depressive disorders were recruited from the Child Psychiatry Outpatient Clinic of Peking University Sixth Hospital between April 2021 and November 2022 (15 males, 56 females; median age 14 [13, 15] years) as the depressive disorder group. Additionally, 83 healthy adolescents (27 males, 56 females; median age 14 [13, 17] years) were recruited as the control group during the same period. Internet addiction was assed using the Chinese version of Young′s Internet Addiction Test (YIAT), with a total score≥50 indicating internet addiction. Impulsivity was evaluated using the Barratt Impulsiveness Scale-11(BIS-11), and aggression was measured with the Buss-Perry Aggression Questionnaire(BPAQ). Differences in internet addiction, impulsivity, and aggression between the depression group and the control group were analyzed. Pearson correlation analysis was used to explore the correlation between internet addiction and impulsivity, aggression. Hierarchical linear regression models were used to analyze the factors influencing internet addiction, and a parallel mediation model was used to examine the mediating effect of impulsivity and aggressive personality traits in the relationship between depressive disorders and internet addiction.Results:The prevalence of IA was significantly higher in adolescents with depression than the healthy control group [57.75%(41/71) vs 31.33%(26/83); χ 2=10.87, P<0.001]. Adolescents with depressive disorders also exhibited higher impulsivity (65.5±9.2 vs 57.0±9.2, t=-5.72, P<0.001) and aggression (56.3±16.0 vs 42.4±15.1, t=-5.13, P<0.001) compared to the control group. Internet addiction was positively correlated with aggression ( r=0.47, P<0.01) and impulsivity ( r=0.57, P<0.01). Hierarchical regression analysis with the YIAT total score as the dependent variable revealed that impulsivity ( β=0.48, P<0.001) and aggression ( β=0.24, P<0.001) significantly predicted internet addiction. Mediation analysis indicated that depressive disorders indirectly indirectly influenced internet addiction through parallel paths of impulsivity and aggression, with a total indirect effect of 0.543 (95% CI: 0.362-0.761). Conversely, internect addiction influenced depressive disorders through reverse parallel pathway of impulsivity and aggression with a total indirect effect of 0.038 (95% CI: 0.021-0.067). Direct effects were not significant in either direction. Conclusion:Adolescents with depressive disorders exhibit more internet addiction. Impulsivity and aggressive personality traits play bidirectional mediating roles in the relationship between depressive disorders and internet addiction.

Objective To explore the influencing factors of early postpartum pelvic organ prolapse(POP)after vaginal delivery in advanced maternal age primipara.Methods Clinical data of 153 postpartum women were collected from Beijing Tongren Hospital Mentougou Campus,Capital Medical University,from June 2015 to May 2024.According to whether pelvic organ prolapse occurred during the 6-week postpartum reexamination of the primiparas,the parturients were divided into two groups:non-POP group(91 cases)and POP group(62 cases).Univariate and multivariate Logistic regression analyses were conducted to identify the independent factors influencing early postpartum POP.Subgroup analysis was also performed to assess the relationship between family history of POP and early postpartum POP after adjusting for confounding factors.Results Multivariate Logistic regression analysis revealed that neonatal birth weight,maternal pre-pregnancy body mass index(BMI),use of delivery balls,and family history of POP were independent factors associated with early postpartum POP occurrence(P＜0.05).Among the parturients who did not use of delivery balls,before and after using Logistic regression to adjust for birth weight,pre-pregnancy BMI and perineal laceration,the impact of family history of POP on the occurrence of POP was statistically significant(P＜0.05).However,among the parturients who used the delivery balls,regardless of whether the adjustment was made or not,the impact of family history of POP on the occurrence of POP was not statistically significant(P＞0.05).Conclusion Neonatal birth weight,maternal pre-pregnancy BMI,and family history of POP are risk factors for early postpartum POP,while the use of delivery balls is a protective factor.Women with a family history of POP are advised to use delivery balls to reduce the risk of early postpartum POP.

Objective To explore the influencing factors of early postpartum pelvic organ prolapse(POP)after vaginal delivery in advanced maternal age primipara.Methods Clinical data of 153 postpartum women were collected from Beijing Tongren Hospital Mentougou Campus,Capital Medical University,from June 2015 to May 2024.According to whether pelvic organ prolapse occurred during the 6-week postpartum reexamination of the primiparas,the parturients were divided into two groups:non-POP group(91 cases)and POP group(62 cases).Univariate and multivariate Logistic regression analyses were conducted to identify the independent factors influencing early postpartum POP.Subgroup analysis was also performed to assess the relationship between family history of POP and early postpartum POP after adjusting for confounding factors.Results Multivariate Logistic regression analysis revealed that neonatal birth weight,maternal pre-pregnancy body mass index(BMI),use of delivery balls,and family history of POP were independent factors associated with early postpartum POP occurrence(P＜0.05).Among the parturients who did not use of delivery balls,before and after using Logistic regression to adjust for birth weight,pre-pregnancy BMI and perineal laceration,the impact of family history of POP on the occurrence of POP was statistically significant(P＜0.05).However,among the parturients who used the delivery balls,regardless of whether the adjustment was made or not,the impact of family history of POP on the occurrence of POP was not statistically significant(P＞0.05).Conclusion Neonatal birth weight,maternal pre-pregnancy BMI,and family history of POP are risk factors for early postpartum POP,while the use of delivery balls is a protective factor.Women with a family history of POP are advised to use delivery balls to reduce the risk of early postpartum POP.

Objective:To construct a risk prediction model based on explainable intelligence(XAI)analysis algorithms for orthopedic consumables in surgery room,and improve the management quality of controlling risk for orthopedic consumables in surgery room.Methods:A risk index system for orthopedic consumables in the surgery room was established through researching literature and using Delphi method.The data of supply and use of consumables were collected to construct a risk prediction model.Risk control paths were formulated from three aspects included formulating preoperative plan,intraoperative dynamic allocation,and postoperative tracking and feedback.A total of 6,572 sets of orthopedic consumables that were used in the surgery room of the 960th Hospital of People's Liberation Army Joint Service Support Force from January 2021 to December 2024 were selected.The 3,185 sets of orthopedic consumables that were used during January 2021 and December 2022 were managed by using conventional method of controlling and managing risk.The 3,387 sets of orthopedic consumables that were used during January 2023 and December 2024 were managed by using intelligent method of controlling and managing risk.The early warning capabilities for risk,and the control quality for risk between the two management methods were compared.A self-made satisfaction survey questionnaire was adopted to investigate the satisfaction scores of medical staffs and managers for consumables in the surgery room for the two management methods.Results:The average accuracy rates of using the intelligent method of controlling and managing risk in predicting formulating preoperative plan,intraoperatively dynamic allocation,and postoperative tracking and feedback for early warning events of risk in 157,247 and 57 consumables were respectively 49.68%(78/157),42.11%(104/247)and 56.14%(32/57),all of which were higher than those of conventional method of controlling and managing risk,and the difference were statistically significant(x2=9.475,23.637,13.035,P<0.05).The average reduction rate of risk events of consumables,the average intervention rate of abnormal use of consumables,and the mean value of enhance degree of turnover efficiency of consumables were respectively(6.25±1.59)%,(87.93±4.44)%and(4.78±1.69)%,all of which were higher than those of conventional method of controlling and managing risk,and the differences were statistically significant(t=4.952,6.257,4.660,P<0.05).The scores of medical staffs and managers in surgery room for acceptance of early warning for risk,support of management decision,satisfaction of using consumables,and assessment results of training by adopting intelligent method of controlling and managing risk were all higher than those by adopting conventional method of controlling and managing risk,and the differences were statistically significant(t=3.368,3.082,3.701,4.558,P<0.05).Conclusion:The application of prediction model based on XAI analysis algorithm for risk of orthopedic consumables in the surgery room can improve the accuracy of early warning for risk of orthopedic consumables in the surgery room,and reduce the incidence of risk events,and enhance the ability of emergent response for risk,and improve the quality of clinical services.