[Objective]To investigate the role of endothelial microparticles(EMPs)in diabetic macrovascular complications(DMCs),summarize the research progress and analyze the research progress on traditional Chinese medicine(TCM)regulation of EMPs for the prevention and treatment of DMCs.[Methods]Base on the research on the pathological mechanism of DMCs,the biological characteristic of EMPs and their mechanism of action in DMCs in recent years,combined with the experimental and clinical studies on the regulation of EMPs by TCM for disease prevention and treatment,their paper summarizes the action targets of EMPs in regulating the pathological process of DMCs and the resarch progress of TCM intervention,on this basis,the limitations of current research and future prospects are summarized.[Results]EMPs are important biomarkers of endothelial injury,promoting mechanisms such as inflammation,oxidative stress,thrombosis and atherosclerosis,contributes to the pathological progression of DMCs.TCM intervenes in the generation and release of EMPs through mechanisms such as regulating inflammatory responses,alleviating oxidative stress,relieving endothelial dysfunction and promoting vascular repair.This approach helps maintain endothelial homeostasis and plays a crucial role in the prevention and treatment of DMCs.[Conclusion]EMPs play a significant role in the onset and progression of DMCs,serving as potential intervention targets.TCM offers novel therapeutic approaches for the prevention and treatment of DMCs by inhibiting inflammation and oxidative stress,promoting vascular remodeling and repair,and suppressing the formation of thrombosis and atherosclerosis.

[Objective]To investigate the role of endothelial microparticles(EMPs)in diabetic macrovascular complications(DMCs),summarize the research progress and analyze the research progress on traditional Chinese medicine(TCM)regulation of EMPs for the prevention and treatment of DMCs.[Methods]Base on the research on the pathological mechanism of DMCs,the biological characteristic of EMPs and their mechanism of action in DMCs in recent years,combined with the experimental and clinical studies on the regulation of EMPs by TCM for disease prevention and treatment,their paper summarizes the action targets of EMPs in regulating the pathological process of DMCs and the resarch progress of TCM intervention,on this basis,the limitations of current research and future prospects are summarized.[Results]EMPs are important biomarkers of endothelial injury,promoting mechanisms such as inflammation,oxidative stress,thrombosis and atherosclerosis,contributes to the pathological progression of DMCs.TCM intervenes in the generation and release of EMPs through mechanisms such as regulating inflammatory responses,alleviating oxidative stress,relieving endothelial dysfunction and promoting vascular repair.This approach helps maintain endothelial homeostasis and plays a crucial role in the prevention and treatment of DMCs.[Conclusion]EMPs play a significant role in the onset and progression of DMCs,serving as potential intervention targets.TCM offers novel therapeutic approaches for the prevention and treatment of DMCs by inhibiting inflammation and oxidative stress,promoting vascular remodeling and repair,and suppressing the formation of thrombosis and atherosclerosis.

Background: and Purpose Posterior cerebral artery occlusion (PCAo) can cause long-term disability, yet randomized controlled trials to guide optimal reperfusion strategy are lacking. We compared the outcomes of PCAo patients treated with endovascular thrombectomy (EVT) with or without intravenous thrombolysis (IVT) to patients treated with IVT alone. Methods: From the multicenter retrospective Posterior cerebraL ArTery Occlusion (PLATO) registry, we included patients with isolated PCAo treated with reperfusion therapy within 24 hours of onset between January 2015 and August 2022. The primary outcome was the distribution of the modified Rankin Scale (mRS) at 3 months. Other outcomes comprised 3-month excellent (mRS 0–1) and independent outcome (mRS 0–2), early neurological improvement (ENI), mortality, and symptomatic intracranial hemorrhage (sICH). The treatments were compared using inverse probability weighted regression adjustment. Results: Among 724 patients, 400 received EVT+/-IVT and 324 IVT alone (median age 74 years, 57.7% men). The median National Institutes of Health Stroke Scale score on admission was 7, and the occluded segment was P1 (43.9%), P2 (48.3%), P3–P4 (6.1%), bilateral (1.0%), or fetal posterior cerebral artery (0.7%). Compared to IVT alone, EVT+/-IVT was not associated with improved functional outcome (adjusted common odds ratio [OR] 1.07, 95% confidence interval [CI] 0.79–1.43). EVT increased the odds for ENI (adjusted OR [aOR] 1.49, 95% CI 1.05–2.12), sICH (aOR 2.87, 95% CI 1.23–6.72), and mortality (aOR 1.77, 95% CI 1.07–2.95). Conclusion Despite higher odds for early improvement, EVT+/-IVT did not affect functional outcome compared to IVT alone after PCAo. This may be driven by the increased risk of sICH and mortality after EVT.

Objective To explore the value of real-time shear wave elastography in evaluating gastrocnemius muscle elasticity in patients with lumbar disc herniation.Methods One hundred patients with clinically diagnosed unilateral lumbar disc herniation were selected.Selective nerve root block combined with ozone ablation and pulsed radiofrequency therapy via the lateral crypt was performed.The real-time shear wave elastography was applied to detect the mean elastic modulus (Mean) and the maximum elastic modulus (Max) of bilateral tense gastrocnemius muslcs (kPa) before and after treatment.Statistical analysis was done.Results The EMean and EMax values of ipsilateral tension in gastrocnemius muscle before treatment were (11.28±2.60)kPa and (15.26±2.63)kPa,lower than those of contralateral (EMean:[16.284-5.25]kPa,EMax:[21.13±6.62]kPa;t=78.241,64.634,both P＜0.001).The EMean and EMax values of ipsilateral tension in gastrocnemius muscle after treatment were (13.18±2.38)kPa and (17.63± 2.73)kPa,higher than those before treatment (t=6.407,14.815,both P＜0.001).In different strength condition,EMean and EMax of gastrocnemius muscle before and after treatment were statistically significant (all P＜0.001).With the myodynamia increasing,EMean and EMax also increased before and after treatment.The differences between patients with any two different myodynamia were statistically different (all P＜0.05).Conclusion The muscle tissue recovery can be evaluated quantitatively by detecting EMean and EMax of tense gastrocnemius in patients with lumbar disc herniation using real-time shear wave elastography before and after treatment.