Objective To explore the insulin resistance(IR),serum cortisol.level and circadian secretion rhythm in the patients with pituitary adenoma(PA).Methods Sixty-seven patients with PA in this hospital from October 2016 to April 2017 were selected as the observation group,including 23 cases of pituitary Cushing syndrome,15 cases of growth hormone adenoma,16 cases of prolactinoma and 13 cases of non-functioning adenoma.Contemporaneous 49 individuals undergoing healthy physical examination were selected as the control group.The biochemical indexes of fasting plasma glucose(FPG),fasting insulin(FINS) and serum cortisol were measured and the homeostasis model assessment for insulin resistance(HOMA-IR) was determined.The correlation between insulin resistance and serum cortisol was analyzed.Results The incidence rate of cortisol circadian rhythm disorder in the observation group was 58.21％,the level of fasting serum cortisol in abnormal secretion rhythm of PA group was higher than that in normal secretion rhythm of PA group and control group(P＜0.05);the levels of FINS and HOMA-IR in the pituitary Cushing syndrome and growth hormone adenoma group were higher than those in the control group,the correlation analysis showed that HOMA-IR in PA patients was positively correlated with fasting serum cortisol level and FINS level(P＜0.05).Conclusion The IR occurrence exists in pituitary Cushing syndrome and growth hormone adenoma,which may be closely correlated with serum cortisol increase.

MLLT6(Myeloid/Lymphoid or mixed-lineage leukemia(Trithorax homolog,Drosophila);Translocated to,6),also known as AF17(ALL1 fused gene from chromosome 17 protein)and located in chromosome 17 long arm 2 zone 1 band(17q21),was originally isolated as a MLL partner gene in leukemia.It has been reported that MLLT6 has the function of maintaining blood pressure stability.MLLT6 synergistically promotes the development of acute myeloid leukemia(AML)as an oncogene or a gene fusion with mixed lineage leukemia(t(11;17)(q23;q21)).This article provides a comprehensive overview of the research progress of MLLT6 and MLL-MLLT6 fusion protein in leukemia.