Objective:To compare the efficacies of endovascular therapy (EVT) and standard medical therapy in acute ischemic stroke (AIS) patients aged ≥85 years, and analyze the independent influencing factors for poor prognosis of AIS patients after EVT.Methods:Sixty-nine AIS patients aged ≥85 years admitted to Department of Neurology, Xi'an Third Hospital from January 2018 to April 2024, including 40 accepted EVT and 28 accepted standard medicinal therapy, were enrolled. Modified Rankin scale (mRS) was used to evaluate the prognosis of the patients 90 days after onset. General data, prognosis and complications between the EVT group and standard medical therapy group were compared. General data, treatment processes and complications between patients with good prognosis and poor prognosis in the EVT group were compared. Multivariate Logistic regression was used to analyze the independent influencing factors for poor prognosis in AIS patients after EVT.Results:Compared with the standard medical therapy, the EVT group had significantly lower NIHSS score at discharge, greater improvement in NIHSS score (NIHSS score at admission-NIHSS score at discharge), lower mRS score 90 days after onset, higher good prognosis rate, lower mortality rate within 90 days of onset, and longer hospital stay ( P<0.05). In the EVT group, 11 patients (27.5%) had good prognosis and 29 patients (72.5%) had poor prognosis 90 days after onset. Compared with the good prognosis group, the poor prognosis group had significantly higher blood glucose level and lower Alberta Stroke Program Early CT Score (ASPECT) on admission ( P<0.05). Multivariate Logistic regression analysis showed that blood glucose on admission ( OR=2.363, 95% CI: 1.134-4.928, P=0.022) and ASPECT score on admission ( OR=0.273, 95% CI: 0.088-0.854, P=0.026) were independent influencing factors for poor prognosis in AIS patients after EVT. Conclusion:AIS patients aged ≥85 years received EVT have better prognosis compared with those accepted standard medical therapy; these patients with high glucose level and low ASPECT score on admission have poor prognosis.

Objective To observe the clinical and imaging features of patients with severe cerebral venous sinus thrombosis(CVST).Methods Consecutive severe CVST patients diagnosed at the Affiliated Hospital of Northwestern University(Xi'an NO.3 Hospital)from January 2017 to July 2024 were included.Patients'demographic characteristics,clinical manifestations,risk factors,imaging characteristics,onset mode,D-dimer levels,time from onset to diagnosis,treatment strategies,and prognosis were collected and recorded.Results A total of 17 severe CVST patients were included,of which 4 cases(23.5％)were male and 13 cases(76.5％)were female,with a male-to-female ratio of 1∶3.25.The median age was 41 years(range:19-56 years).The main clinical symptoms were headache,nausea and vomiting,seizures,focal neurological deficits,psychiatric symptoms,disturbance of consciousness,and limited neck mobility.The most common clinical symptoms were headache(15/17),seizures(7/17),and focal neurological deficits(7/17),followed by disturbance of consciousness(4/17).Among the 17 patients,10 cases(58.8％)had ischemic stroke and 9 cases(52.9％)had hemorrhagic stroke.The involvement rates of transverse sinus,superior sagittal sinus,sigmoid sinus,straight sinus and inferior sagittal sinus were 94.1％,64.7％,47.1％,29.4％and 11.8％respectively,and the proportion of patients with involvement of 2 or more venous sinuses reached 88.2％.Among the 17 patients,12 cases exhibited a lack of response to standard anticoagulation therapy and underwent endovascular therapy subsequently,and one of them had new intracranial hemorrhage.Two(11.8％)patients had poor prognosis at 90 d after discharge,with one patient death and one patient with an mRS score of 3.Fifteen patients(88.2％)had a good prognosis(3 cases with an mRS score of 2,5 cases with an mRS score of 1,and 7 cases with an mRS score of 0).Conclusions Severe CVST patients often present with seizures,impaired consciousness,involvement of multiple venous sinuses,ischemic stroke,and hemorrhagic stroke.Early identification,and active anticoagulation or endovascular therapy are crucial to improve the prognosis and reduce the disability and mortality rates of this disease.

Objective To observe the clinical and imaging features of patients with severe cerebral venous sinus thrombosis(CVST).Methods Consecutive severe CVST patients diagnosed at the Affiliated Hospital of Northwestern University(Xi'an NO.3 Hospital)from January 2017 to July 2024 were included.Patients'demographic characteristics,clinical manifestations,risk factors,imaging characteristics,onset mode,D-dimer levels,time from onset to diagnosis,treatment strategies,and prognosis were collected and recorded.Results A total of 17 severe CVST patients were included,of which 4 cases(23.5％)were male and 13 cases(76.5％)were female,with a male-to-female ratio of 1∶3.25.The median age was 41 years(range:19-56 years).The main clinical symptoms were headache,nausea and vomiting,seizures,focal neurological deficits,psychiatric symptoms,disturbance of consciousness,and limited neck mobility.The most common clinical symptoms were headache(15/17),seizures(7/17),and focal neurological deficits(7/17),followed by disturbance of consciousness(4/17).Among the 17 patients,10 cases(58.8％)had ischemic stroke and 9 cases(52.9％)had hemorrhagic stroke.The involvement rates of transverse sinus,superior sagittal sinus,sigmoid sinus,straight sinus and inferior sagittal sinus were 94.1％,64.7％,47.1％,29.4％and 11.8％respectively,and the proportion of patients with involvement of 2 or more venous sinuses reached 88.2％.Among the 17 patients,12 cases exhibited a lack of response to standard anticoagulation therapy and underwent endovascular therapy subsequently,and one of them had new intracranial hemorrhage.Two(11.8％)patients had poor prognosis at 90 d after discharge,with one patient death and one patient with an mRS score of 3.Fifteen patients(88.2％)had a good prognosis(3 cases with an mRS score of 2,5 cases with an mRS score of 1,and 7 cases with an mRS score of 0).Conclusions Severe CVST patients often present with seizures,impaired consciousness,involvement of multiple venous sinuses,ischemic stroke,and hemorrhagic stroke.Early identification,and active anticoagulation or endovascular therapy are crucial to improve the prognosis and reduce the disability and mortality rates of this disease.

Objective:To compare the efficacies of endovascular therapy (EVT) and standard medical therapy in acute ischemic stroke (AIS) patients aged ≥85 years, and analyze the independent influencing factors for poor prognosis of AIS patients after EVT.Methods:Sixty-nine AIS patients aged ≥85 years admitted to Department of Neurology, Xi'an Third Hospital from January 2018 to April 2024, including 40 accepted EVT and 28 accepted standard medicinal therapy, were enrolled. Modified Rankin scale (mRS) was used to evaluate the prognosis of the patients 90 days after onset. General data, prognosis and complications between the EVT group and standard medical therapy group were compared. General data, treatment processes and complications between patients with good prognosis and poor prognosis in the EVT group were compared. Multivariate Logistic regression was used to analyze the independent influencing factors for poor prognosis in AIS patients after EVT.Results:Compared with the standard medical therapy, the EVT group had significantly lower NIHSS score at discharge, greater improvement in NIHSS score (NIHSS score at admission-NIHSS score at discharge), lower mRS score 90 days after onset, higher good prognosis rate, lower mortality rate within 90 days of onset, and longer hospital stay ( P<0.05). In the EVT group, 11 patients (27.5%) had good prognosis and 29 patients (72.5%) had poor prognosis 90 days after onset. Compared with the good prognosis group, the poor prognosis group had significantly higher blood glucose level and lower Alberta Stroke Program Early CT Score (ASPECT) on admission ( P<0.05). Multivariate Logistic regression analysis showed that blood glucose on admission ( OR=2.363, 95% CI: 1.134-4.928, P=0.022) and ASPECT score on admission ( OR=0.273, 95% CI: 0.088-0.854, P=0.026) were independent influencing factors for poor prognosis in AIS patients after EVT. Conclusion:AIS patients aged ≥85 years received EVT have better prognosis compared with those accepted standard medical therapy; these patients with high glucose level and low ASPECT score on admission have poor prognosis.

Objective:To study the high-performance liquid chromatographic(HPLC) fingerprints of different germplasms of Flos Carthami. Methods: HPLC was applied in chromatographic separation of 36 different germplasms of Flos Carthami collected from 11 provinces of China.The chromatography condition was: Agilent Zorbax C_(18) column(4.6 mm?250 mm,5 mm);mobile phase: CAN,0.5% H_3PO_4(from 1090 to 8020);running time: 60 min;flow speed: 1.0 ml/min;detection wavelength: 265 nm;and temperature: 20℃.The data were processed by Chromatographic Fingerprint Station designed by Department of Pharmaceutical Analysis,School of Pharmacy,Second Military Medical University.Different germplasms of Flos Carthami were subjected to cluster analysis and their similarity was also evaluated.Results: The different germplasms of Flos Carthami in this study were grouped into 2 chemical types.Samples from northwest of China were of high similarity;samples from the middle China were of high similarity to those from South China.The similarity of some germplasms of Flos Carthami was significantly different.Conclusion: The chemical components of different germplasms of Flos Carthami are obviously different from each other;selection of germplasm is very important in quality control of Flos Carthami.