Objective To explore the value of CT-guided needle positioning in preoperative localization of pulmonary ground glass nodules(GGN).Methods Clinical data of 110 patients with pulmonary GGN treated in the Wuxi Hospital from March 2017 to December 2021 were collected.Before thoracoscopic surgery,CT-guided needle positioning was conducted,and the accuracy and effectiveness of positioning were observed.Results The lesions were located in the lateral side of the lungs in 72 patients and in the middle lateral sides of the lungs in 38 patients,with the puncture success rates being 93.06%and 86.84%,respectively(P<0.01).The positioning time,incidence of complications,surgical time,extubation time and hospital stay in patients with the lesions located in lateral lungs were lower than those located in middle lateral lungs.Postoperative pathological results were taken as the gold standard,and the sensitivity,specificity,and accuracy of CT-guided needle positioning were 90.20%,75.00%,and 89.09%,respectively.Conclusion Preoperative CT-guided needle positioning can help to shorten the localization time of operation,surgical time and extubation time,and reduce complications.