Post-stroke cognitive impairment(PSCI) is one of the common complications in stroke patients, mainly manifested as impairments in memory, attention, and orientation. Adenosine monophosphate-activated protein kinase(AMPK), as a crucial intracellular energy sensor, has attracted extensive research attention in the field of PSCI in recent years. This paper provides a comprehensive review of the research progress on AMPK-related signaling pathways and their roles in PSCI, with a focus on exploring action mechanisms of AMPK in processes such as oxidative stress, neuroinflammation, autophagy, and apoptosis. Additionally, it summarizes the prospects and challenges of AMPK as a potential target for improving PSCI, aiming to offer new theoretical foundations for the clinical prevention and treatment of PSCI.

To explore the law and characteristics of adverse events of medical devices and to provide research methods and basis for reducing the recurrence of similar adverse events, we collect medical devices safety information from five representative countries in the world, and make statistics and analysis on the types of events, the types of management and the causes of events. The results show that among 136 serious adverse events, the top three causes of recall are product design factors, software factors, and component defects. In order to reduce the application risk of medical devices, it is suggested that product designers, operating users and medical institutions should correctly implement the monitoring and evaluation system of medical devices.
Equipment Safety ; Equipment and Supplies/adverse effects* ; Product Surveillance, Postmarketing ; Software