Fluid resuscitation is vital in the treatment of diabetic ketoacidosis (DKA) patients. The purpose of this narrative review is to analyze the role of Plasmalyte in the fluid resuscitation of adult DKA patients. A thorough search was conducted in PubMed, MEDLINE, and Embase. Studies conducted between January 1, 2010, and March 31, 2023, were collected. Of 123 results, five pertinent randomized controlled trials were included. The close resemblance of Plasmalyte’s electrolyte composition to that of human plasma, and its role in the prevention of hyperchloremic metabolic acidosis are some of its key benefits in patients with diabetic ketoacidosis. Plasmalyte’s role in length of stay, time to resolution of diabetic ketoacidosis, and mortality in DKA patients varied among studies. Hence, further research on these topics is needed.