Purpose: To evaluate systemic oxidative stress by comparing serum 8-hydroxy-2′-deoxyguanosine (8-OHdG), coenzyme Q10 (CoQ10), malondialdehyde (MDA), and 25-hydroxyvitamin D (25(OH)D) levels between primary open-angle glaucoma (POAG) patients and healthy controls. Methods: This prospective case-control study included 37 POAG patients and 35 age-matched controls. Serum levels were measured via enzyme-linked immunosorbent assay. Nonparametric tests (Mann-Whitney U-test and Spearman correlations) and multivariate linear regression adjusting for age and sex were used. Results: POAG patients showed significantly higher MDA (3.01 vs. 2.46 nmol/mL, p = 0.021) and 8-OHdG (9.34 vs. 6.52 ng/mL, p < 0.001), but lower CoQ10 (7.28 vs. 8.98 ng/mL, p < 0.001) and 25(OH)D (15.02 vs. 17.45 ng/mL, p = 0.013). MDA and 8-OHdG showed a strong positive correlation (rho = 0.855, p < 0.001). CoQ10 and 8-OHdG showed a moderate positive correlation (rho = 0.466, p = 0.004). No significant correlation was found between 25(OH)D and 8-OHdG (rho = –0.118, p = 0.488). After adjusting for age and sex, POAG remained independently associated with lower CoQ10 (p < 0.001). No oxidative marker correlated with intraocular pressure, visual field mean deviation, or retinal nerve fiber layer thickness in POAG patients (all p > 0.05). Conclusions POAG patients exhibit systemic oxidative imbalance with elevated oxidative damage and reduced antioxidant capacity. The positive CoQ10–8-OHdG correlation may suggest a compensatory relationship. This imbalance is associated with POAG but does not correlate with clinical severity cross-sectionally, suggesting it reflects a systemic disease component rather than a direct severity marker.

BACKGROUND AND OBJECTIVES: We have intended to investigate the influence of the timing of invasive procedures on all-cause mortality, recurrent myocardial infarction (MI), re-hospitalization due to cardiac causes and left ventricular function over a 3-month period among patients with Non-ST-elevation myocardial infarction (NSTEMI). SUBJECTS AND METHODS: A total of 131 NSTEMI patients with moderate-high Thrombolysis in Myocardial Infarction risk scores, who had been admitted to our department between July 2011-December 2011 were included in our study. They had been randomized into 2 groups according to the timing of the percutaneous coronary intervention (PCI). Patient undergoing PCI in the first 24 hours of hospitalization were named the "Early Invasive Group" and those undergoing PCI between 24-72 hours of hospitalization were named the "Delayed Invasive Group". All patients were followed up for 3 months. RESULTS: Third month left ventricular ejection fraction (LVEF) values were higher in the early invasive group (59.9+/-6.0% vs. 54.1+/-8.7%; p<0.001). Recurrent MI rates were lower in the early invasive group (2.9% vs. 14.5%; p=0.016). Similarly, hospitalization rates due to cardiac events were lower in the early invasive group (8.7% vs. 30.6%; p=0.001). All cause mortality appeared to be lower in the early invasive group, although not to a statistically significant degree (0% vs. 4.8%; p=0.065). CONCLUSION: The early invasive strategy appears to be more effective for the reduction of recurrent MI, re-hospitalization due to cardiac events, and the preservation of 3rd month LVEF in patients with moderate-high risk NSTEMI when compared to a delayed invasive strategy.
Hospitalization ; Humans ; Mortality ; Myocardial Infarction* ; Percutaneous Coronary Intervention* ; Prognosis ; Stroke Volume ; Ventricular Function, Left