ObjectiveTo find out whether there is any difference in the monitoring results of mosq-ovitraps placed in different orientations in multi-storey residential areas, so as to provide a scientific basis for routine and emergency monitoring of Aedes albopictus with mosq-ovitraps in residential areas. MethodsFrom July 6th to October 26th 2023, one mosquito ovitrap was set up in each of the 4 orientations of east, south, west and north around the buildings in a multi-storey residential area in Jinhui Town, Fengxian District, Shanghai. Data was collected and recorded 72 hours after placement. The chi-square test was used to compare the mosquito ovitrap indices (MOIs) of two independent samples, and the Kruskal⁃Wallis H test was used to compare the MOIs of multiple independent samples. ResultsAfter 16 weeks of surveillance, 997 mosquito ovitraps were recovered, of which 211 were positive, with the mosquito ovitrap index (MOI) of 21.16% and the Aedes albopictus density index of 1.03 mosquitoes·ovitrap^-1. The MOIs were higher in September (24.22%) and October (23.96%), and the MOIs in the west, south and north within the two months were all above 20.00%. From July to October, the MOIs in the east, west, south and north were 20.70%, 22.20%, 25.50% and 16.20%, respectively, and the difference in MOIs among the 4 orientations was not statistically significant (χ²=6.647, P=0.084). Stratified analysis by month showed that in August, the south side of the multi-storey residential areas had the highest MOI (31.30%), the north side had the lowest MOI (1.30%), and there was a statistically significant difference in MOI in the east, west, south and north (χ²=25.986, P<0.001). In October, the MOI in the west was the highest (33.30%) and the MOI in the east was the lowest (6.30%), the difference in MOIs of the 4 orientations was statistically significant (χ²=12.007, P=0.007). The MOIs in the south side of the building in the outskirts of the residential area from the 1st week in July to the 4th week in October was lower (19.20%) than that in the south side of the inner building (31.70%), and the difference in MOI was statistically significant (χ²=5.118, P=0.024). ConclusionThe study of MOI in different orientations in a multi-storey residential area is a preliminary exploration based on field work, and the results show that there is a difference in MOIs in different orientations during the peak breeding period of mosquitoes. Further indicators such as temperature, humidity and wind speed in different orientations can be collected to explore the influencing factors of MOIs.

Background Kurtosis reflecting noise's temporal structure is an effective metric for evaluating noise-induced hearing loss (NIHL), and its threshold is still unclear. Objective To explore the energy range of kurtosis and the threshold of NIHL induced by kurtosis in this energy rangeMethods Using cross-sectional design, 4631 noise-exposed workers in manufacturing industry were selected. The hearing loss and noise exposure data of each worker were collected. Logistic regression model was used to establish the dose-response relationship between noise exposure and hearing loss and estimate the range of energy effects. Restricted cubic spline model was utilized to analyze the dose-response relationship curves of kurtosis to noise-induced hearing loss (NIHI) and high-frequency noise-induced hearing loss (HFNIHL) under different 8 h equivalent sound levels (L_{EX,8 h}), as well as to estimate the kurtosis effect threshold. Results The logistic regression model analysis showed that the prevalence of NIHI and HFNIHL increased significantly with increase of L_{EX,8 h} for steady noise; when L_{EX,8 h} of non-steady noise was 80-100 dB(A), the risk of hearing loss increased with an increase in kurtosis (P<0.05). The restricted cubic spline model showed that when L_{EX,8 h} of non-steady noise was 0-80 dB(A) or >100 dB(A), there was no significant relationship between kurtosis and NIHI or HFNIHL. When L_{EX,8 h} was 80-100 dB(A), there was a significant nonlinear dose-response relationship between kurtosis and NIHL or HFNIHL (P <0.001), and kurtosis > 28.08 exerted effect in elevating NIHI or HFNIHL. Conclusion The effect threshold of kurtosis on NIHL is 28.08 when non-steady noise levels are in the range of 80-100 dB(A). The effect threshold of kurtosis needs further verification.

Strengthening comprehensive quality and safety management is great significance in improving the level of medical services,ensuring patient safety and enhancing medical efficiency.On the basis of discussing the significance and role of building a smart medical quality management system,it has sorted out the key paths of data integration and sharing,data analysis and mining,intelligent decision-making support,operation optimisation and efficiency enhancement,information security and privacy protection,talent cultivation and digital literacy enhancement,and put forward the suggestions to jointly promote the construction of the management system from the aspects of policy guidance,multi-party collaboration,and technological innovation.

Strengthening comprehensive quality and safety management is great significance in improving the level of medical services,ensuring patient safety and enhancing medical efficiency.On the basis of discussing the significance and role of building a smart medical quality management system,it has sorted out the key paths of data integration and sharing,data analysis and mining,intelligent decision-making support,operation optimisation and efficiency enhancement,information security and privacy protection,talent cultivation and digital literacy enhancement,and put forward the suggestions to jointly promote the construction of the management system from the aspects of policy guidance,multi-party collaboration,and technological innovation.

Objective:To analyze the clinical data and genetic characteristics of a child with CLN1 neuronal ceroid lipofuscinosis in conjunct with hereditary hyperferritinemia cataract syndrome (HHCS).Methods:A child who was admitted to the PICU of the First Affiliated Hospital of Zhengzhou University in November 2020 was selected as the study subject. Clinical data of the child was collected. Genetic testing was carried out for the child, and the result was analyzed in the light of literature review to explore the clinical and genetic characteristics to facilitate early identification.Results:The patient, a 3-year-old male, had mainly presented with visual impairment, progressive cognitive and motor regression, and epilepsy. Cranial magnetic resonance imaging revealed deepened sulci in bilateral cerebral hemispheres, and delayed myelination. The activity of palmitoyl protein thioesterase was low (8.4 nmol/g/min, reference range: 132.2 ~ 301.4 nmol/g/min), whilst serum ferritin was increased (2 417.70 ng/mL, reference range: 30 ~ 400 ng/mL). Fundoscopy has revealed retinal pigment degeneration. Whole exome sequencing revealed that he has harbored c. 280A>C and c. 124-124+ 3delG compound heterozygous variants of the PPT1 gene, which were respectively inherited from his father and mother. Neither variant has been reported previously. The child has also harbored a heterozygous c. -160A>G variant of the FTL gene, which was inherited from his father. Based on the clinical phenotype and results of genetic testing, the child was diagnosed as CLN1 and HHCS. Conclusion:The compound heterozygous variants of the PPT1 gene probably underlay the disorders in this child. For children with CLN1 and rapidly progressing visual impairment, ophthalmological examination should be recommended, and detailed family history should be taken For those suspected for HHCS, genetic testing should be performed to confirm the diagnosis.

Strengthening comprehensive quality and safety management is great significance in improving the level of medical services,ensuring patient safety and enhancing medical efficiency.On the basis of discussing the significance and role of building a smart medical quality management system,it has sorted out the key paths of data integration and sharing,data analysis and mining,intelligent decision-making support,operation optimisation and efficiency enhancement,information security and privacy protection,talent cultivation and digital literacy enhancement,and put forward the suggestions to jointly promote the construction of the management system from the aspects of policy guidance,multi-party collaboration,and technological innovation.

Strengthening comprehensive quality and safety management is great significance in improving the level of medical services,ensuring patient safety and enhancing medical efficiency.On the basis of discussing the significance and role of building a smart medical quality management system,it has sorted out the key paths of data integration and sharing,data analysis and mining,intelligent decision-making support,operation optimisation and efficiency enhancement,information security and privacy protection,talent cultivation and digital literacy enhancement,and put forward the suggestions to jointly promote the construction of the management system from the aspects of policy guidance,multi-party collaboration,and technological innovation.

Strengthening comprehensive quality and safety management is great significance in improving the level of medical services,ensuring patient safety and enhancing medical efficiency.On the basis of discussing the significance and role of building a smart medical quality management system,it has sorted out the key paths of data integration and sharing,data analysis and mining,intelligent decision-making support,operation optimisation and efficiency enhancement,information security and privacy protection,talent cultivation and digital literacy enhancement,and put forward the suggestions to jointly promote the construction of the management system from the aspects of policy guidance,multi-party collaboration,and technological innovation.

Strengthening comprehensive quality and safety management is great significance in improving the level of medical services,ensuring patient safety and enhancing medical efficiency.On the basis of discussing the significance and role of building a smart medical quality management system,it has sorted out the key paths of data integration and sharing,data analysis and mining,intelligent decision-making support,operation optimisation and efficiency enhancement,information security and privacy protection,talent cultivation and digital literacy enhancement,and put forward the suggestions to jointly promote the construction of the management system from the aspects of policy guidance,multi-party collaboration,and technological innovation.