Objective To explore the effects of MOTOmed intelligent training combined with standing balance training on the recovery of lower limb motor function and balance in stroke patients with hemiplegia.Methods A total of 124 patients with post-stroke hemiplegia who received rehabilitation care in the Sixth People's Hospital of Nantong from May 2022 to May 2024 were selected as research objects.They were assigned to observation group(62 cases)or control group(62 cases)using a random number table.The control group received MOTOmed intelligent training,and the observation group received MOTOmed intelligent training combined with standing balance training.After 2 months of rehabilitation,the lower limb motor function(Fugl-Meyer assessment lower extremity subscale[FMA-LE]score,time up and go test[TUGT],balance function,postural stability[length and area of center of gravity movement,average trajectory error,completion time],quality of life(stroke specific quality of life[SS-QOL]),and self-care ability(Barthel index[BI])were compared between the two groups.Results After interventions,the FMA-LE scores of the observation group and control group were 19.41±5.72 and 16.08±4.41,respectively;the TUGT result was(40.06±12.35)s and(45.13±10.97)s;the station balance scores were 2.83±0.71 and 2.57±0.63;the walking function balance scores were 2.91±0.43 and 2.75±0.41;the lengths of center of gravity movement were(246.05±45.63)mm and(279.61±42.01)mm;the area of center of gravity movement was(92.75±22.16)mm2 and(102.36±27.84)mm2;the average trajectory error was(21.14±5.06)%and(25.78±5.42)%;the completion time of the tests was(79.24±5.06)s and(82.87±6.73)s;the SS-QOL scores were 138.91±32.05 and 125.65±34.83;BI was 51.24±7.91 and 46.05±6.63.There were significant differences in these indexes between the two groups(all P<0.05).Conclusion MOTOmed intelligent training combined with standing balance training can promote the recovery of lower limb motor function,improve lower limb motor balance,and enhance the quality of life of stroke patients with hemiplegia.

There are many abnormal signaling pathways in the occurrence, development and microenvironment of liver cancer. The abnormal activation or inhibition of cell signaling pathway can regulate cell proliferation, apoptosis and migration, and then affect inflammation, angiogenesis and tumor migration. Experimental studies have shown that Traditional Chinese medicine (TCM) can prevent and treat hepatocellular carcinoma by intervention with the transduction of related signaling pathways, which mainly includes hedgehog signaling pathway, IL-6/STAT3 signaling pathway, NF-κB signaling pathway, PI3K/Akt/mTOR signaling pathway, MAPK signaling pathway, toll-like receptor signaling pathway and Wnt signaling pathway. At present stage, TCM has a definite effect on the prevention and treatment of liver cancer, but the specific mechanism has not been fully elucidated, and the regulation of TCM on liver cancer related signaling pathways still needs further exploration.

OBJECTIVETo evaluate the biomechanical effects of intracellular changes on the voltage-gated sodium channels (VGSCs) on trigeminal ganglion neuron (TRGN).

METHODSTRGN cells were acutely isolated from the neonatal SD rats. The voltage-dependent currents of the VGSCs on these neurons were elicited and analyzed by whole-cell patch-clamp recordings and the intracellular anisotonicity stimuli was established by adjusting the content of pipette solution. The effects of hypo-(260 mOsm) and hypertonic (350 mOsm) osmolarity on the activation and inactivation kinetics of VGSCs on TRGN were evaluated, compared with the normal intracellular environment.

RESULTSThe results demonstrated that intracellular hypotonic stimuli could influence both the activation and inactivation characteristics of VGSCs currents, including the membrane potential at half inactivation (V0.5) of the G-V and inactivation curves had obvious statistics significance (P<0.05) between hypotonicity (260mOsm) and isotonicity (306mOsm). However, only inactivation properties changed under intracellular hypertonic effects, including inactivation rate and k value.

CONCLUSIONIt suggests that the kinetics of VGSCs on TRGN can be modulated both by intracellular hypo- and hypertonic with different characteristics.

Animals ; Cells, Cultured ; Membrane Potentials ; Neurons ; Osmolar Concentration ; Patch-Clamp Techniques ; Rats ; Rats, Sprague-Dawley ; Sodium Channels ; Trigeminal Ganglion