Objective To evaluate the clinical effect of 3D printing-assisted percutaneous screw fixation in treating unstable pelvic fracture.Methods A total of 80 patients with unstable pelvic fractures,who received treatment at the Lianyungang Municipal First People's Hospital of China from January 2022 to January 2023,were enrolled in this study.According to the surgical methods,the patients were divided into percutaneous screw fixation group(n=47,receiving 3D printing-assisted percutaneous screw fixation)and open reduction group(n=33,receiving open reduction with steel plate internal fixation).The intraoperative blood loss,time spent for surgery,total hospitalization time,fracture healing time,levels of serum creatine kinase(CK),myoglobin(Myo),lactate dehydrogenase(LDH)levels,and incidence of surgical complications were compared between the two groups.Results In the percutaneous screw fixation group,the time spent for surgery[(62.96±19.31)min vs(100.07±26.71)min],intraoperative blood loss[(112.71±25.43)mL vs(230.65±30.29)mL],total hospitalization time[(11.04±2.35)days vs(15.16±2.58)days]and fracture healing time[(102.18±9.74)days vs(113.42±11.52)days]were remarkably higher than those in the open reduction group(all P＜0.01);the postoperative 3-month total effective rate was 95.74％,which was significantly higher than 80.00％in the open reduction group(P＜0.05);and the excellent rate of fracture reduction quality was higher than that in the open reduction group(P＜0.05).The postoperative one-,3-and 6-month Majeed scores in the percutaneous screw fixation group were strikingly higher than those in the open reduction group(all P＜0.05).No statistically significant differences in the preoperative levels of CK,Myo and LHD existed between the two groups(all P＞0.05),while the postoperative levels of CK,Myo and LHD in the percutaneous screw fixation group were prominently lower than those in the open reduction group(all P＜0.05).The difference in the incidence of postoperative complications between the two groups was not statistically significant(P＞0.05).Conclusion For the treatment of unstable pelvic fracture,3D printing-assisted percutaneous screw fixation is superior to open reduction with plate internal fixation in achieving better clinical results,reducing surgical injury,and shortening postoperative recovery time.

Objective To reduce the thrombosis probability and hemolysis risk of the meglev left ventricular assist device (LVAD), so as to increase the efficiency of blood supply. Methods The influences of the pump outlet diameter, exit angle, fillet size between the outlet and the inner wall of the pump, as well as gap between the rotor and the shell on internal flow field of the pump were studied by using the computational fluid dynamics (CFD) method, so as to optimize the internal structure and improve the hydrodynamic performance of the pump. Results Compared with pump of the previous generation, the maximum wall shear stress (WSS) of the pump inner wall, the maximum WSS of the pump rotor, the area with WSS >200 Pa were reduced by 23.6%, 47.4%, 76.2%, respectively, while the outlet flow was increased by 14.4%. Conclusions For the meglev LVAD of the new generation, its internal blood flow tended to be smooth, and the hemodynamic performance of blood flow was improved comprehensively. The research findings provide references for optimization design of the meglev LVAD and related experimental researches in the future.

Background and purpose:As one of the most fatal malignant tumors in China, the morbidity and mortality of lung cancer remain high. Early diagnosis and normative treatment is the key to improve the prognosis of lung cancer. The aim of this study was to explore the practice of early lung cancer screening with low-dose spiral computed tomography (CT) based on the current situation in community health service, with integration of superior resources of med-ical institutions at all levels in Shanghai.Methods:From Aug. 2013 to Aug. 2014, we screened high-risk population in selected communities of Minhang District, Shanghai, for early diagnosis of lung cancer with low-dose spiral CT combined with multidisciplinary comprehensive treatment models including minimally invasive surgery, exploring the medical service network covering prevention, diagnosis, treatment, rehabilitation and follow-up.Results:Screening population is 11 332 (male 7 144, female 4 188); Twenty-nine cases with pathological diagnosis of malignant tumor, including 27 cases of pri-mary lung cancer, 1 case of lung metastasis, 1 case of breast cancer. The morbidity of primary lung cancer is 238.26×10-5. There were 22 cases of Stage 0-Ⅰ lung cancer accounting for 81.48% of all diagnosed primary lung cancer.Conclusion:Based on community health service, screening with low-dose spiral CT could improve the early diagnosis rate of lung can-cer with feasibility and validity, which could be applicable in qualified eligible medical center and community in China.

OBJECTIVETo study the value of clinical application and distribution character of regional pulmonary ventilation of patients with various type of pneumoconiosis.

METHODS132 patients with various type of pneumoconiosis were observed by electric impedance pneumograph(EIPV) and routine lung function test. The results were compared with the measured value of 100 healthy cases.

RESULTSThe regional pulmonary ventilation of the three kinds of pneumoconiosis(founder's pneumoconiosis, silicosis and asbestosis) was increased in both side of upper pulmonary region and decreased in both of lower pulmonary region. The ventilation distribution showed that the right pulmonary ventilation increased predominantly, accounted for 53.03% (70/132) of total lung ventilation. There was significant difference(P < 0.01) compared with the normal healthy men's EIPV, but no difference(P > 0.05) among various type of pneumoconiosis. There was also no difference(P > 0.05) between pneumoconiosis patients with normal ventilation function and various type of ventilation obstacle of pneumoconiosis. One silicosis patient complicated by atelectasis of the left upper lobe, another silicosis patient complicated by lung cancer and their EIPV accorded with their chest X-rays.

CONCLUSIONEIPV could not be measured by routine lung function test. It may be the supplement to latter parameter and as a substitute for radio imaging of pulmonary ventilation in pneumoconiosis complicated by other regional pulmonary disorder.

Electric Impedance ; Humans ; Pneumoconiosis ; diagnosis ; physiopathology ; Pulmonary Ventilation ; Respiratory Function Tests

Objective　To investigate the cold preservation effect on rat livers of a modified storage method with self-made HYD solution. Methods　The vascular bed of rat livers was expanded with an additional 20 to 40?ml self-made HYD solution/100?g liver. After resection of the liver, the extra HYD solution (expressed as % liver weight) was entrapped via portal infusion by tying off the supra- and infra-hepatic inferior vena cava. Forty rats were randomly divided into four groups including control group with conventional storage method, and 20%, 30% and 40% groups according to the amount of extra HYD solution. We compared the preservation effect of the modified storage method with that of the conventional storage method using an isolated perfused rat liver model. Results　Bile production and all the indices of hepatic microcirculation including portal perfusion pressure, endothelin-1 in the effluent, trypan blue distribution time and histology were significantly superior in the modified method groups compared to those in the control group (P<0.05). The contents of dihydroxybenzoic acid (DHBA) in the modified method groups were significantly lower than those in the control group (P<0.05). Liver enzymes activities in the 30% group were markedly lower than those in the control group (P<0.05). The preservation effect on rat liver in the 30% group was the best among the modified method groups. Conclusion　The modified cold storage method is effective and may have potential for clinical application in liver preservation.

Objective To find out current distribution of Oncomelania snails and Schistosoma infection in snails in Zhejiang Province, so as to improve the project of schistosomiasis control. Methods Investigation spots were selected by stratified cluster sampling method, 100 villages of 34 counties were selected from 7 106 villages of 55 counties as survey spots. Synchronously systematic and environmental samplings were used for the survey. Snails were dissected to determine the infection status and spots with sham snails were set to assess the quality of the survey. Results The result showed that snails were found in 223 strips, 1 572 frames and 73 300 m 2 area in 32 villages of 21 counties. Snails were found in an area covering 72 640 m 2 in 29 villages of 18 counties in hilly region, which accounted for 99.1% of total snail habitats. The significantly larger area with snails was revealed in hilly region than that in water network region (t=3.04, P