Objective:To investigate the incidence of mild cognitive impairment(MCI)and malnutrition among centenarians, as well as to explore the relationship between cognitive impairment and nutritional status.Methods:A cross-sectional study was conducted between November and December 2023, involving 121 elderly individuals aged ≥ 100 years in the Baoshan District of Shanghai.The survey collected general information and included the Ascertain Dementia 8-item Questionnaire(AD8), the Mini Nutritional Assessment Short-Form(MNA-SF), and anthropometric nutritional measurements such as waist circumference(WC), hip circumference(HC), arm circumference(AC), calf circumference(CC), and grip strength.The prevalence of MCI and malnutrition among centenarians was calculated, and the correlation between MCI and MNA-SF scores, along with anthropometric nutritional measurement indicators, was analyzed.Results:The age range of centenarians was between 100 and 105 years, with an average age of 101.0±3.5 years.The majority of centenarians were female(76.9%), illiterate(58.7%), and lived with family members(73.6%).All participants had medical insurance(100%).Most had no history of long-term smoking 118(97.5%), long-term alcohol consumption 108(89.3%), long-term use of health supplements 109(90.1%), long-term tea or coffee habits 114(94.2%), chronic medical conditions 84(69.4%), or family history of dementia 102(84.3%).Additionally, 62(51.2%)reported their health status over the past year as general.According to the AD8 screening results, the negative and positive detection rates of MCI in centenarians were 79(65.3%)and 47(34.7%), respectively.Based on the MNA-SF scoring results, the detection rates of normal nutrition, malnutrition risk, and malnutrition among centenarians were 36(29.8%), 61(50.4%), and 24(19.8%), respectively.There was a statistically significant difference in AC between the non-MCI group and the MCI group among centenarians( t=0.01, P=0.03).The AD8 scores of centenarians were significantly negatively correlated with AC, CC, and MNA-SF scores( r=-0.20, r=-0.26, r=-0.29; all P<0.05). Conclusions:The cognitive function of centenarians is associated with their nutritional status, indicating that higher cognitive abilities correlate with better nutritional status.

Objective:To investigate the incidence of mild cognitive impairment(MCI)and malnutrition among centenarians, as well as to explore the relationship between cognitive impairment and nutritional status.Methods:A cross-sectional study was conducted between November and December 2023, involving 121 elderly individuals aged ≥ 100 years in the Baoshan District of Shanghai.The survey collected general information and included the Ascertain Dementia 8-item Questionnaire(AD8), the Mini Nutritional Assessment Short-Form(MNA-SF), and anthropometric nutritional measurements such as waist circumference(WC), hip circumference(HC), arm circumference(AC), calf circumference(CC), and grip strength.The prevalence of MCI and malnutrition among centenarians was calculated, and the correlation between MCI and MNA-SF scores, along with anthropometric nutritional measurement indicators, was analyzed.Results:The age range of centenarians was between 100 and 105 years, with an average age of 101.0±3.5 years.The majority of centenarians were female(76.9%), illiterate(58.7%), and lived with family members(73.6%).All participants had medical insurance(100%).Most had no history of long-term smoking 118(97.5%), long-term alcohol consumption 108(89.3%), long-term use of health supplements 109(90.1%), long-term tea or coffee habits 114(94.2%), chronic medical conditions 84(69.4%), or family history of dementia 102(84.3%).Additionally, 62(51.2%)reported their health status over the past year as general.According to the AD8 screening results, the negative and positive detection rates of MCI in centenarians were 79(65.3%)and 47(34.7%), respectively.Based on the MNA-SF scoring results, the detection rates of normal nutrition, malnutrition risk, and malnutrition among centenarians were 36(29.8%), 61(50.4%), and 24(19.8%), respectively.There was a statistically significant difference in AC between the non-MCI group and the MCI group among centenarians( t=0.01, P=0.03).The AD8 scores of centenarians were significantly negatively correlated with AC, CC, and MNA-SF scores( r=-0.20, r=-0.26, r=-0.29; all P<0.05). Conclusions:The cognitive function of centenarians is associated with their nutritional status, indicating that higher cognitive abilities correlate with better nutritional status.

Objective To investigate experience of nursing intervention in patients with diabetic foot.Methods 46 diabetic foot patients were randomly divided into intervention group and control group.23 patients in the control group received standard nursing received conventional nursing while 23 patients in the intervention group received comprehensive nursing intervention. Nursing effect was observed in the two groups.Results The number of patients with diabetic foot after nursing intervention was more than that in the control group.There were 16 patients cured and 4 patients amputated due to serious infection and 3 patients failed to heal due to economic rea-sons,the result revealed that the difference was statistically significant (P <0.05).Conclusion Diabetic foot patients received effective nursing intervention can significantly improve the efficacy and reduce the incidence of complications.

Obj ective To explore yhe effecys of peer suppory on compliance of insulin inj ec-yion in payienys wiyh yype 2 diabeyes(T2DM).Methods 1 10 payienys wiyh T2DM were divided inyo inyervenyion group and conyrol group wiyh 55 payienys in each group.The conyrol group was given convenyional healyh educayion and healyh educayion mayerials while yhe inyervenyion group was given peer suppory inyervenyion for 3 monyhs.Quesyionnaire invesyigayion of yhe compliance of insulin in-j ecyion,self managemeny behavior change and syandard raye of blood glucose were recorded and ana-lyzed respecyively before inyervenyion,in one monyh and yhree monyhs afyer inyervenyion.Results Compliance in inyervenyion group was beyyer yhan yhay in yhe conyrol group (P<0 .05 ).Prescribed medicayion,diey,exercises,self moniyoring and diseases recheck in yhe inyervenyion group were bey-yer yhan yhay in yhe conyrol group(P<0.05).FBG,PG in 2 h,HbA1c in yhe inyervenyion group were beyyer yhan yhose of yhe conyrol group (P<0 .05 ).Conclusion Peer suppory guided by dia-beyic specialisy nurses could improve yhe compliance of insulin yreaymeny and self managemeny,and conyrol yhe level of blood glucose.

Objective To investigate experience of nursing intervention in patients with diabetic foot.Methods 46 diabetic foot patients were randomly divided into intervention group and control group.23 patients in the control group received standard nursing received conventional nursing while 23 patients in the intervention group received comprehensive nursing intervention. Nursing effect was observed in the two groups.Results The number of patients with diabetic foot after nursing intervention was more than that in the control group.There were 16 patients cured and 4 patients amputated due to serious infection and 3 patients failed to heal due to economic rea-sons,the result revealed that the difference was statistically significant (P <0.05).Conclusion Diabetic foot patients received effective nursing intervention can significantly improve the efficacy and reduce the incidence of complications.

Obj ective To explore yhe effecys of peer suppory on compliance of insulin inj ec-yion in payienys wiyh yype 2 diabeyes(T2DM).Methods 1 10 payienys wiyh T2DM were divided inyo inyervenyion group and conyrol group wiyh 55 payienys in each group.The conyrol group was given convenyional healyh educayion and healyh educayion mayerials while yhe inyervenyion group was given peer suppory inyervenyion for 3 monyhs.Quesyionnaire invesyigayion of yhe compliance of insulin in-j ecyion,self managemeny behavior change and syandard raye of blood glucose were recorded and ana-lyzed respecyively before inyervenyion,in one monyh and yhree monyhs afyer inyervenyion.Results Compliance in inyervenyion group was beyyer yhan yhay in yhe conyrol group (P<0 .05 ).Prescribed medicayion,diey,exercises,self moniyoring and diseases recheck in yhe inyervenyion group were bey-yer yhan yhay in yhe conyrol group(P<0.05).FBG,PG in 2 h,HbA1c in yhe inyervenyion group were beyyer yhan yhose of yhe conyrol group (P<0 .05 ).Conclusion Peer suppory guided by dia-beyic specialisy nurses could improve yhe compliance of insulin yreaymeny and self managemeny,and conyrol yhe level of blood glucose.

Various cancers have seriously threatened human' s health. Screening newer and more effective anticancer agents from natural sources to cure these diseases is the focus in research. As novel sources of potential medicine, a number of metabolites isolated from endophytic fungi have been proved to have anticancer bioactivity. Usually, these endophytic fungi have special biochemical pathway and they can accumulate anticancer agents in cultures such as taxane, alkaloids, cytochalasins, podophyllotoxin, brefeldin A and so forth. The research advance on anticancer agents purified from endophytic fungi is expatiated systemically. In addition, the strategy of screening anticancer agents as well as the prospect on this area is introduced briefly.