Objective To investigate the relationship between serum G protein-coupled estrogen receptor 1(GPER1),complement factor H(CFH)levels and pregnancy outcomes in patients with gestational diabetes mellitus(GDM).Methods A total of 120 patients with GDM(GDM group)and 60 healthy pregnant women(control group)were included in this study.According to the pregnancy outcome,GDM patients were divided into the adverse pregnancy outcome(APO)group(50 cases)and the non-APO group(70 cases).The basic data of GDM patients were collected.Fasting blood glucose,fasting insulin and blood lipids were measured,and homeostasis model assessment of insulin resistance index(HOMA-IR)was calculated.The serum levels of GPER1 and CFH were detected by enzyme-linked immunosorbent assay.Pearson correlation analysis was used to analyze the correlation between serum levels of GPER1,CFH and HOMA-IR in GDM patients.Multivariate unconditional Logistic regression and receiver operating characteristic(ROC)curve were used to analyze the relationship between serum GPER1 and CFH levels and APO in GDM patients and to predict energy efficiency.Results Compared with the control group,serum levels of GPER1 and CFH were increased in the GDM group(P<0.05).Serum GPER1 and CFH levels were positively correlated with HOMA-IR in GDM patients(r=0.722 and 0.714,respectively,P<0.001).Compared with the non-APO group,serum levels of GPER1 and CFH were increased in the APO group(P<0.05).Elevated levels of HOMA-IR,GPER1 and CFH were independent risk factors for APO in GDM patients(P<0.05).The combined prediction of serum GPER1 and CFH[AUC=0.887(95%CI:0.816-0.937)]was superior to serum GPER1[AUC=0.789(95%CI:0.705-0.858)]and CFH[AUC=0.786(95%CI:0.701-0.856)]alone in predicting APO in GDM patients.Conclusion Serum levels of GPER1 and CFH in GDM patients are increased,which are closely related to the enhancement of insulin resistance and APO.The combination of the two has a higher predictive efficiency for APO.

Objective To investigate the relationship between serum G protein-coupled estrogen receptor 1(GPER1),complement factor H(CFH)levels and pregnancy outcomes in patients with gestational diabetes mellitus(GDM).Methods A total of 120 patients with GDM(GDM group)and 60 healthy pregnant women(control group)were included in this study.According to the pregnancy outcome,GDM patients were divided into the adverse pregnancy outcome(APO)group(50 cases)and the non-APO group(70 cases).The basic data of GDM patients were collected.Fasting blood glucose,fasting insulin and blood lipids were measured,and homeostasis model assessment of insulin resistance index(HOMA-IR)was calculated.The serum levels of GPER1 and CFH were detected by enzyme-linked immunosorbent assay.Pearson correlation analysis was used to analyze the correlation between serum levels of GPER1,CFH and HOMA-IR in GDM patients.Multivariate unconditional Logistic regression and receiver operating characteristic(ROC)curve were used to analyze the relationship between serum GPER1 and CFH levels and APO in GDM patients and to predict energy efficiency.Results Compared with the control group,serum levels of GPER1 and CFH were increased in the GDM group(P<0.05).Serum GPER1 and CFH levels were positively correlated with HOMA-IR in GDM patients(r=0.722 and 0.714,respectively,P<0.001).Compared with the non-APO group,serum levels of GPER1 and CFH were increased in the APO group(P<0.05).Elevated levels of HOMA-IR,GPER1 and CFH were independent risk factors for APO in GDM patients(P<0.05).The combined prediction of serum GPER1 and CFH[AUC=0.887(95%CI:0.816-0.937)]was superior to serum GPER1[AUC=0.789(95%CI:0.705-0.858)]and CFH[AUC=0.786(95%CI:0.701-0.856)]alone in predicting APO in GDM patients.Conclusion Serum levels of GPER1 and CFH in GDM patients are increased,which are closely related to the enhancement of insulin resistance and APO.The combination of the two has a higher predictive efficiency for APO.

Objective To investigate the relationships of serum levels of Xenin-25 and activin A with pregnancy outcomes in patients with gestational diabetes mellitus(GDM).Methods A total of 269 pregnant women with GDM admitted to our hospital between December 2020 and February 2023 were enrolled.Serum levels of Xenin-25 and activin A were measured,and pregnancy outcomes were recorded.Based on pregnancy outcomes,patients were divided into poor pregnancy outcome group(91 cases)and good pregnancy outcome group(178 cases).The influencing factors of adverse preg-nancy outcomes of GDM patients and the predictive value of Xenin-25 and activin A for GDM preg-nancy outcomes were analyzed.Results The poor pregnancy outcome group had higher age,pre-pregnancy body mass index(BMI),proportion of adverse obstetric history,as well as levels of fasting plasma glucose(FPG),glycated hemoglobin(HbA1c),and activin A compared to the good preg-nancy outcome group,and serum level of Xenin-25 was lower in the poor pregnancy outcome group(P＜0.05).High HbA1c and high activin A levels were identified as risk factors for pregnancy out-comes in GDM patients,while high Xenin-25 was a protective factor for pregnancy outcomes(P＜0.05).The areas under the curve(AUCs)for predicting adverse pregnancy outcomes in GDM pa-tients using Xenin-25 and activin A were 0.895 and 0.865,respectively,while the AUC for com-bined prediction was 0.981,which was higher than that of Xenin-25 or activin A alone(P＜0.05).Conclusion Xenin-25 and activin A in GDM patients are associated with adverse pregnancy outcomes and can serve as biomarkers for predicting pregnancy outcomes.

A 74-year-old male patient was treated with pemetrexed on the basis of erlotinib for lung adenocarcinoma. For the first time, pemetrexed 800 mg dissolved in 0.9% sodium chloride 100 ml was given by intravenous injection. On the 3rd day after the treatment, the patient developed generalized skin rash, and then ulceration of oral mucosa and skin ulceration of perianal and scrotal area gradually appeared. The patient was diagnosed with exfoliative dermatitis. On the 6th day after the treatment, the patient developed diarrhea, which was gradually aggravated with the increased frequency from 3 to 4 times to 10 to 12 times daily. On the 9th day, after the treatment the patient developed myelosuppression (grade IV), with white blood cell count (WBC) 0.6×10 9/L, neutrophils count 0.1×10 9/L, red blood cell count (RBC) 2.04×10 12/L, hemoglobin (Hb) 65 g/L, and platelet count (PLT) 77×10 9/L. Despite the active treatments with anti-allergy, antidiarrheal, and blood cell regeneration stimulating drugs, the patient′s myelosuppression was aggravated. On the 15th day after the treatment, laboratory tests showed WBC 0.1×10 9/L, neutrophil count 0, RBC 2.53×10 12/L, Hb 80 g/L, and PLT 1×10 9/L. The patient′s treatment was given up at the request of his family members and the patient died on the 18th day after the treatment.

A 74-year-old male patient was treated with pemetrexed on the basis of erlotinib for lung adenocarcinoma. For the first time, pemetrexed 800 mg dissolved in 0.9% sodium chloride 100 ml was given by intravenous injection. On the 3rd day after the treatment, the patient developed generalized skin rash, and then ulceration of oral mucosa and skin ulceration of perianal and scrotal area gradually appeared. The patient was diagnosed with exfoliative dermatitis. On the 6th day after the treatment, the patient developed diarrhea, which was gradually aggravated with the increased frequency from 3 to 4 times to 10 to 12 times daily. On the 9th day, after the treatment the patient developed myelosuppression (grade IV), with white blood cell count (WBC) 0.6×10 9/L, neutrophils count 0.1×10 9/L, red blood cell count (RBC) 2.04×10 12/L, hemoglobin (Hb) 65 g/L, and platelet count (PLT) 77×10 9/L. Despite the active treatments with anti-allergy, antidiarrheal, and blood cell regeneration stimulating drugs, the patient′s myelosuppression was aggravated. On the 15th day after the treatment, laboratory tests showed WBC 0.1×10 9/L, neutrophil count 0, RBC 2.53×10 12/L, Hb 80 g/L, and PLT 1×10 9/L. The patient′s treatment was given up at the request of his family members and the patient died on the 18th day after the treatment.

Objective To investigate the status and influencing factors of quality of life among middle-aged and elderly patients with knee osteoarthritis (KOA) in rural area of Tangshan city. Methods 216 KOA patients were investigated with the demographic data questionnaire,the Numerical Rating Scale (NRS), the Arthritis Impact Measurement Scale 2 short form (AIMS2-SF) and the Western Ontario and McMaster Universities (WOMAC) Osteoarthritis index. Results The score of AIMS2-SF was (73.10±14.72) and the average score of each dimension was in the middle level. WOMAC Osteoarthritis index, levels of pain, economic status and marital status were the main predictors of their quality of life. Conclusion The quality of life of middle-aged and elderly patients with KOA in the rural area of Tangshan city was in the middle level and interventions targeted at the influencing factors should be enhanced to improve the quality of life.