Purpose: The purpose of this study was to compare the positive outcomes of fixed night shift, such as fatigue recovery experiences, work-life balance, and retention intentions, among nurses who had experienced both rotating shifts and fixed night shift. Methods: A single-cohort pre-post study design was used to compare the fatigue recovery experience, work-life balance, and retention intentions of nurses who have experienced fixed night shift. The study included 59 nurses working at a single university hospital in Seoul from September 1, 2023, to December 31, 2023. Data were analyzed using frequency and percentage, mean and standard deviation, t-test and ANOVA, paired t-test using the R statistical program. Results: The results revealed that acute and chronic fatigue levels decreased among nurses of night shifts during fatigue recovery assessment.However, the inter-shift recovery score did not improve, indicating that nurses' fatigue recovery was insufficient. Work-life balance scores increased, particularly in the area of work-leisure balance. Retention intention also improved among nurses of fixed night shift, but this was not statistically significant. Conclusion Based on the results of this study, the successful establishment of a fixed night shift system will reduce the turnover rate of the next generation of nurses and create a medical environment where nurses can spend more time on direct patient nursing care. Furthermore, we hope to improve the quality of life of nurses and improve the health outcomes of patients.

Purpose: The purpose of this study was to compare the positive outcomes of fixed night shift, such as fatigue recovery experiences, work-life balance, and retention intentions, among nurses who had experienced both rotating shifts and fixed night shift. Methods: A single-cohort pre-post study design was used to compare the fatigue recovery experience, work-life balance, and retention intentions of nurses who have experienced fixed night shift. The study included 59 nurses working at a single university hospital in Seoul from September 1, 2023, to December 31, 2023. Data were analyzed using frequency and percentage, mean and standard deviation, t-test and ANOVA, paired t-test using the R statistical program. Results: The results revealed that acute and chronic fatigue levels decreased among nurses of night shifts during fatigue recovery assessment.However, the inter-shift recovery score did not improve, indicating that nurses' fatigue recovery was insufficient. Work-life balance scores increased, particularly in the area of work-leisure balance. Retention intention also improved among nurses of fixed night shift, but this was not statistically significant. Conclusion Based on the results of this study, the successful establishment of a fixed night shift system will reduce the turnover rate of the next generation of nurses and create a medical environment where nurses can spend more time on direct patient nursing care. Furthermore, we hope to improve the quality of life of nurses and improve the health outcomes of patients.

Purpose: The purpose of this study was to compare the positive outcomes of fixed night shift, such as fatigue recovery experiences, work-life balance, and retention intentions, among nurses who had experienced both rotating shifts and fixed night shift. Methods: A single-cohort pre-post study design was used to compare the fatigue recovery experience, work-life balance, and retention intentions of nurses who have experienced fixed night shift. The study included 59 nurses working at a single university hospital in Seoul from September 1, 2023, to December 31, 2023. Data were analyzed using frequency and percentage, mean and standard deviation, t-test and ANOVA, paired t-test using the R statistical program. Results: The results revealed that acute and chronic fatigue levels decreased among nurses of night shifts during fatigue recovery assessment.However, the inter-shift recovery score did not improve, indicating that nurses' fatigue recovery was insufficient. Work-life balance scores increased, particularly in the area of work-leisure balance. Retention intention also improved among nurses of fixed night shift, but this was not statistically significant. Conclusion Based on the results of this study, the successful establishment of a fixed night shift system will reduce the turnover rate of the next generation of nurses and create a medical environment where nurses can spend more time on direct patient nursing care. Furthermore, we hope to improve the quality of life of nurses and improve the health outcomes of patients.

Purpose: The purpose of this study was to compare the positive outcomes of fixed night shift, such as fatigue recovery experiences, work-life balance, and retention intentions, among nurses who had experienced both rotating shifts and fixed night shift. Methods: A single-cohort pre-post study design was used to compare the fatigue recovery experience, work-life balance, and retention intentions of nurses who have experienced fixed night shift. The study included 59 nurses working at a single university hospital in Seoul from September 1, 2023, to December 31, 2023. Data were analyzed using frequency and percentage, mean and standard deviation, t-test and ANOVA, paired t-test using the R statistical program. Results: The results revealed that acute and chronic fatigue levels decreased among nurses of night shifts during fatigue recovery assessment.However, the inter-shift recovery score did not improve, indicating that nurses' fatigue recovery was insufficient. Work-life balance scores increased, particularly in the area of work-leisure balance. Retention intention also improved among nurses of fixed night shift, but this was not statistically significant. Conclusion Based on the results of this study, the successful establishment of a fixed night shift system will reduce the turnover rate of the next generation of nurses and create a medical environment where nurses can spend more time on direct patient nursing care. Furthermore, we hope to improve the quality of life of nurses and improve the health outcomes of patients.

PURPOSE: Programmed death-1 (PD-1)/PD-1 ligand (PD-L1) axis blockades have revolutionized the treatment of advanced non-small cell lung cancer (NSCLC). We assessed the effect of platinum-based chemotherapy on tumor PD-L1 expression and its clinical implications. MATERIALS AND METHODS: We used immunohistochemistry to retrospectively evaluate the percentage of tumor cells with membranous PD-L1 staining (tumor proportion score) in paired tumor specimens obtained before and after platinum-based neoadjuvant chemotherapy (NACT) in 86 patients with NSCLC. We analyzed the correlation between the change in PD-L1 tumor proportion score and clinicopathologic characteristics, response to NACT, and survival. RESULTS: The PD-L1 tumor proportion score increased in a significant proportion of patients with NSCLC after platinum-based NACT (Wilcoxon signed-rank test, p=0.002). That pattern was consistent across clinically defined subgroups except for patients with partial response to NACT. Tumors from 26 patients (30.2%) were PD-L1‒negative before NACT but PD-L1-positive after NACT, whereas the reverse pattern occurred in six patients (7%) (McNemar’s test, p < 0.001). Increase in PD-L1 tumor proportion score was significantly associated with lack of response to NACT (Fisher exact test, p=0.015). There was a tendency, albeit not statistically significant, for patients with an increase in PD-L1 tumor proportion score to have shorter survival. CONCLUSION: Tumor PD-L1 expression increased after platinum-based NACT in a significant proportion of patients with NSCLC. Increase in tumor PD-L1 expression may predict poor clinical outcome.
Carcinoma, Non-Small-Cell Lung ; Drug Therapy ; Humans ; Immunohistochemistry ; Neoadjuvant Therapy ; Platinum ; Prognosis ; Retrospective Studies

PURPOSE: The aim of this study is to estimate total sugar intake and identify major food sources of total sugar intake in the diet of the Korean population. METHODS: Dietary intake data of 33,745 subjects aged one year and over from the KNHANES 2008-2011 were used in the analysis. Information on dietary intake was obtained by one day 24-hour recall method in KNHANES. A database for total sugar content of foods reported in the KNHANES was established using Release 25 of the U.S. Department of Agriculture National Nutrient Database for Standard Reference, a total sugar database from the Ministry of Food and Drug Safety, and information from nutrition labeling of processed foods. With this database, total sugar intake of each subject was estimated from dietary intake data using SAS. RESULTS: Mean total sugar intake of Koreans was 61.4 g/person/day, corresponding to 12.8% of total daily energy intake. More than half of this amount (35.0 g/day, 7.1% of daily energy intake) was from processed foods. The top five processed food sources of total sugar intake for Koreans were granulated sugar, carbonated beverages, coffee, breads, and fruit and vegetable drinks. Compared to other age groups, total sugar intake of adolescents and young adults was much higher (12 to 18 yrs, 69.6 g/day and 19 to 29 yrs, 68.4 g/day) with higher beverage intake that beverage-driven sugar amounted up to 25% of total sugar intake. CONCLUSION: This study revealed that more elaborated and customized measures are needed for control of sugar intake of different subpopulation groups, even though current total sugar intake of Koreans was within the range (10-20% of daily energy intake) recommended by Dietary Reference Intakes for Koreans. In addition, development of a more reliable database on total sugar and added sugar content of foods commonly consumed by Koreans is warranted.
Adolescent ; Agriculture ; Asian Continental Ancestry Group ; Beverages ; Bread ; Carbonated Beverages ; Coffee ; Diet ; Energy Intake ; Food Labeling ; Fruit ; Humans ; Korea ; Nutrition Surveys* ; Recommended Dietary Allowances ; Vegetables ; Young Adult

OBJECTIVE: We intended to know how the cryoprotectant ethylene glycol (EG) would affect the outcome of the embryo development when used in slow freezing method. And to know if there is any difference in the outcome of frozen-thawed embryos according to freezing methods and the timing. METHODS: We used 5-6 weeks old ICR female mice and T6 containing 0.4% BSA for basic culture media. The embryos at the developmental stages of 1-cell, 8-cell and blastocyst were cryopreserved respectively by slow freezing method using EG, propylene glycol (PROH), and glycerol as a cryoprotectant. We also compared the results of slow freezing and vitrification methods with the same cryoprotectant, EG. And finally, we evaluated the quality of blastocysts by counting the cell numbers in each group. RESULTS: The post-thaw embryo development were better in EG group when they were frozen at 1-cell and blastocyst stage (P<0.05). Although there were no differences in the recovery rate, the survival rate in vitrification group was significantly higher (P<0.05). Post-thaw embryo development to morula and blastocyst were better in vitrification group when frozen at 1-cell embryo (P<0.05), not at 8-cell and blastocyst group. The cell counts of blastocyst derived from 1-cell stage frozen EG group were significantly increased than that of PROH-glycerol groups (P<0.05), however, there was no difference between the two freezing methods. CONCLUSION: These results suggest that EG may be advantageous comparing with the conventional cryoprotectants, PROH and glycerol in slow freezing method for mouse embryo cryopreservation. In terms of freezing method, vitrification is better than slow freezing.
Animals ; Blastocyst ; Cell Count ; Cryopreservation ; Culture Media ; Embryonic Development ; Embryonic Structures* ; Ethylene Glycol* ; Female ; Freezing* ; Glycerol ; Humans ; Mice* ; Morula ; Pregnancy ; Propylene Glycol ; Survival Rate ; Vitrification

No abstract available.
Biopsy* ; Pleural Effusion*

No abstract available.
Anesthesia, Local* ; Diagnosis* ; Pneumothorax* ; Thoracoscopy*

No abstract available.
Hamartoma*