Heart failure,as a global public health challenge,is experiencing an increasingly severe disease burden.Given the close relationship be-tween the Nitric Oxide-Soluble Guanylate Cyclase-Cyclic Guanosine Monophosphate(NO-sGC-cGMP)signaling pathway and heart failure,this study,through a comprehensive search and review of re-cent literature on the NO-sGC-cGMP pathway and heart failure,aims to outline the mechanism of ac-tion of this signaling pathway and its connection with heart failure,in order to explore new avenues for the treatment of heart failure.

Heart failure,as a global public health challenge,is experiencing an increasingly severe disease burden.Given the close relationship be-tween the Nitric Oxide-Soluble Guanylate Cyclase-Cyclic Guanosine Monophosphate(NO-sGC-cGMP)signaling pathway and heart failure,this study,through a comprehensive search and review of re-cent literature on the NO-sGC-cGMP pathway and heart failure,aims to outline the mechanism of ac-tion of this signaling pathway and its connection with heart failure,in order to explore new avenues for the treatment of heart failure.

Objective To explore the risk factors of postoperative early recurrence in patients with non-small cell lung cancer(NSCLC)and establish a new Nomogram model.Methods The clin-icopathological materials of 236 NSCLC patients with surgical resection in Fuyang Hospital Affiliated to Anhui Medical University and Fuyang City People's Hospital Affiliated to Anhui Medical University from January to August 2021 were retrospectively analyzed,and all the patients were randomly divided into a modeling group(n=165)and a validation group(n=71)with a ratio of 7 to 3.The independ-ent risk factors of postoperative recurrence for NSCLC patients were determined by the univariate and multivariate Cox regression analyses,and a Nomogram model was constructed.The consistency index(C-index),calibration curve and receiver operating characteristics(ROC)curve were used to evalu-ate the predictive ability of the Nomogram model.Results The early recurrence rate of 236 NSCLC patients after surgery was 17.4％(41/236).Univariate and multivariate Cox analyses indicated that lymph node metastasis(HR=2.342,95％CI,1.214 to 4.517,P=0.011),pleural invasion(HR=2.738,95％CI,1.443 to 5.196,P=0.002),vascular invasion(HR=3.526,95％CI,1.802 to 6.899,P＜0.001)and serum D-dimer level(HR=3.656,95％CI,1.265 to 10.561,P=0.017)were the independent predictors of early recurrence and metastasis for NSCLC patients.Based on the above four variables,a Nomogram model was constructed,and the result showed that the C-index of this model in the modeling group and validation group were 0.769(95％CI,0.661 to 0.879)and 0.790(95％CI,0.682 to 0.897)respectively;the area under the curve(AUC)of this model in predicting recurrence free survival(RFS)for patients in the modeling group at 1 year and 2 years was 0.817 and 0.792 respectively,while the AUC for patients in the validation group at 1 year and 2 years was 0.782 and 0.771 respectively.The calibration curve indicated that the predicted probability of this model was consistent with the actual recurrence risk in both groups.Conclusion This Nomo-gram model has good predictive value for early postoperative recurrence of NSCLC,and is of great sig-nificance for assisting clinical doctors in accurately identifying high-risk recurrence populations.

Objective To explore the risk factors of postoperative early recurrence in patients with non-small cell lung cancer(NSCLC)and establish a new Nomogram model.Methods The clin-icopathological materials of 236 NSCLC patients with surgical resection in Fuyang Hospital Affiliated to Anhui Medical University and Fuyang City People's Hospital Affiliated to Anhui Medical University from January to August 2021 were retrospectively analyzed,and all the patients were randomly divided into a modeling group(n=165)and a validation group(n=71)with a ratio of 7 to 3.The independ-ent risk factors of postoperative recurrence for NSCLC patients were determined by the univariate and multivariate Cox regression analyses,and a Nomogram model was constructed.The consistency index(C-index),calibration curve and receiver operating characteristics(ROC)curve were used to evalu-ate the predictive ability of the Nomogram model.Results The early recurrence rate of 236 NSCLC patients after surgery was 17.4％(41/236).Univariate and multivariate Cox analyses indicated that lymph node metastasis(HR=2.342,95％CI,1.214 to 4.517,P=0.011),pleural invasion(HR=2.738,95％CI,1.443 to 5.196,P=0.002),vascular invasion(HR=3.526,95％CI,1.802 to 6.899,P＜0.001)and serum D-dimer level(HR=3.656,95％CI,1.265 to 10.561,P=0.017)were the independent predictors of early recurrence and metastasis for NSCLC patients.Based on the above four variables,a Nomogram model was constructed,and the result showed that the C-index of this model in the modeling group and validation group were 0.769(95％CI,0.661 to 0.879)and 0.790(95％CI,0.682 to 0.897)respectively;the area under the curve(AUC)of this model in predicting recurrence free survival(RFS)for patients in the modeling group at 1 year and 2 years was 0.817 and 0.792 respectively,while the AUC for patients in the validation group at 1 year and 2 years was 0.782 and 0.771 respectively.The calibration curve indicated that the predicted probability of this model was consistent with the actual recurrence risk in both groups.Conclusion This Nomo-gram model has good predictive value for early postoperative recurrence of NSCLC,and is of great sig-nificance for assisting clinical doctors in accurately identifying high-risk recurrence populations.