1.Prevalence and outcome of sarcopenia in patients with inflammatory bowel disease: a follow-up study
Vikram DHARAP ; Devendra DESAI ; Philip ABRAHAM ; Tarun GUPTA ; Pavan DHOBLE ; Nirad MEHTA ; Jagdish MODHE
Intestinal Research 2026;24(1):141-150
Background/Aims:
Sarcopenia is implicated in inflammatory bowel disease (IBD) complications and surgical outcomes. This study aimed to investigate the prevalence and follow-up of sarcopenia in patients with IBD.
Methods:
Consecutive consenting patients with IBD aged > 18 years were included. Patients with associated sarcopenic diseases were excluded. All had measurements of anthropometry, body mass index (BMI), mid-arm muscle circumference, muscle strength, physical performance, and muscle mass (on computed tomography scan). They were followed up for up to 12 months, and incidence of flares, fractures, and surgery was noted.
Results:
Of 157 patients screened, 35 refused participation; 5 with associated sarcopenic diseases were excluded. Of 117 patients (median age, 41 years; interquartile range, 18–81 years; 65 men), 73 had ulcerative colitis, 42 Crohn’s disease, and 2 IBD-unclassified. Forty (34.2%) had probable sarcopenia; 47 (40.2%) had sarcopenia (29 ulcerative colitis and 18 Crohn’s disease) including 10 (8.5%) with severe sarcopenia. Ten (21.3%) were in disease remission. Of factors associated with sarcopenia in univariate analysis, only BMI was significant in multivariate analysis. Ninety-nine patients followed up for a median of 7 months (interquartile range, 2–12 months). Freedom from flares was 5.3% in patients with sarcopenia and 46.1% in those without (P= 0.004). Three patients (1 with sarcopenia, 2 without) required surgery.
Conclusions
Sarcopenia was present in 40% of patients with IBD; one-fifth of these had severe sarcopenia. One-fifth were in remission. Low BMI correlated with sarcopenia. More patients with sarcopenia had disease flare. Screening for sarcopenia should be considered in patients with IBD.
2.Quality of life after prosthodontic rehabilitation in patients with bilateral total maxillectomy due to COVID-19-associated mucormycosis of the maxilla
Gunjan CHOUKSEY ; Vikas GUPTA ; Rupali CHOURE ; Abhijit P. PAKHARE ; Aman DEV ; Bhimsen KUMAR
Archives of Craniofacial Surgery 2024;25(6):285-291
Background:
Coronavirus disease 2019 (COVID-19)-associated mucormycosis of the maxilla emerged as a significant concern in India during the second wave of the pandemic, necessitating surgical interventions such as maxillectomy. This study investigated the quality of life following prosthodontic rehabilitation with interim obturators in patients who underwent bilateral total maxillectomy due to COVID-19-associated mucormycosis of the jaws.
Methods:
The study was conducted using questionnaire-based interviews administered by a single investigator employing the Oral Health Impact Profile-14 (OHIP-14) and Obturator Functioning Scale (OFS) questionnaires. Responses were evaluated on a Likert scale. All statistical analyses were performed using SPSS version 21.0 for Windows. A significance level of 5% was applied to all tests. The Wilcoxon signed-rank and chi-square tests were utilized to compare categorical and quantitative variables across groups. Responses to the questionnaires were recorded on numerical Likert scales ranging from 1 to 5 for OFS and 0 to 4 for OHIP-14. The mean OHIP-14 and OFS scores were compared between the pre-rehabilitation and post-rehabilitation stages.
Results:
A comparison between the pre-rehabilitation and post-rehabilitation scores from the OHIP-14 questionnaire revealed a significant difference (p= 0.001). The OFS results indicated significant improvements across all domains following the use of obturators.
Conclusion
Interim obturators play a vital role in improving speech, swallowing, and mastication during the recovery period for patients who have undergone bilateral total maxillectomy. Despite the altered anatomy resulting from the resection, patients adapted effectively and exhibited improvements in their social, psychological, and mental health.
3.Quality of life after prosthodontic rehabilitation in patients with bilateral total maxillectomy due to COVID-19-associated mucormycosis of the maxilla
Gunjan CHOUKSEY ; Vikas GUPTA ; Rupali CHOURE ; Abhijit P. PAKHARE ; Aman DEV ; Bhimsen KUMAR
Archives of Craniofacial Surgery 2024;25(6):285-291
Background:
Coronavirus disease 2019 (COVID-19)-associated mucormycosis of the maxilla emerged as a significant concern in India during the second wave of the pandemic, necessitating surgical interventions such as maxillectomy. This study investigated the quality of life following prosthodontic rehabilitation with interim obturators in patients who underwent bilateral total maxillectomy due to COVID-19-associated mucormycosis of the jaws.
Methods:
The study was conducted using questionnaire-based interviews administered by a single investigator employing the Oral Health Impact Profile-14 (OHIP-14) and Obturator Functioning Scale (OFS) questionnaires. Responses were evaluated on a Likert scale. All statistical analyses were performed using SPSS version 21.0 for Windows. A significance level of 5% was applied to all tests. The Wilcoxon signed-rank and chi-square tests were utilized to compare categorical and quantitative variables across groups. Responses to the questionnaires were recorded on numerical Likert scales ranging from 1 to 5 for OFS and 0 to 4 for OHIP-14. The mean OHIP-14 and OFS scores were compared between the pre-rehabilitation and post-rehabilitation stages.
Results:
A comparison between the pre-rehabilitation and post-rehabilitation scores from the OHIP-14 questionnaire revealed a significant difference (p= 0.001). The OFS results indicated significant improvements across all domains following the use of obturators.
Conclusion
Interim obturators play a vital role in improving speech, swallowing, and mastication during the recovery period for patients who have undergone bilateral total maxillectomy. Despite the altered anatomy resulting from the resection, patients adapted effectively and exhibited improvements in their social, psychological, and mental health.
4.Occupational Nerve Injuries due to Metallic Foreign Bodies: A Case Series of Eighteen Patients
Gupta P ; Jindal M ; Garg S ; Garg K
Malaysian Orthopaedic Journal 2024;18(No.1):84-90
Introduction: Peripheral nerve injuries (PNIs) remain an
important health problem. PNIs mostly affect young men as
this age group is mostly involved in road traffic accidents
and other injuries at workplace. PNI can occur from foreign
bodies like metal chips while working in industries using
lathe machines. Among PNI’s, injuries to the ulnar nerve, the
brachial plexus and the median nerve are the most frequent
lesions encountered.
Materials and methods: This presentation is on a series of
18 cases of nerve injuries among industrial workers located
from finger level up to the arm excluding the brachial plexus
due to metallic foreign bodies entering while operating lathe
machines over a period of two years with patients being
followed-up over a one year period.
Results: Mean age in this series was 31.3 years with age
range 16-40 years and all were males. Two patients had more
than one nerve involvement and one patient had associated
vascular injury. All the patients showed functional
improvement. Most common nerve injured was median
nerve. Most common site for nerve injury was forearm.
Combined lesions most commonly involved the ulnar and
median nerves.
Conclusion: Social cost of traumatic peripheral nerve
injuries is significant since it has a higher incidence in
young, previously healthy, and economically active
people.
5.Quality of life after prosthodontic rehabilitation in patients with bilateral total maxillectomy due to COVID-19-associated mucormycosis of the maxilla
Gunjan CHOUKSEY ; Vikas GUPTA ; Rupali CHOURE ; Abhijit P. PAKHARE ; Aman DEV ; Bhimsen KUMAR
Archives of Craniofacial Surgery 2024;25(6):285-291
Background:
Coronavirus disease 2019 (COVID-19)-associated mucormycosis of the maxilla emerged as a significant concern in India during the second wave of the pandemic, necessitating surgical interventions such as maxillectomy. This study investigated the quality of life following prosthodontic rehabilitation with interim obturators in patients who underwent bilateral total maxillectomy due to COVID-19-associated mucormycosis of the jaws.
Methods:
The study was conducted using questionnaire-based interviews administered by a single investigator employing the Oral Health Impact Profile-14 (OHIP-14) and Obturator Functioning Scale (OFS) questionnaires. Responses were evaluated on a Likert scale. All statistical analyses were performed using SPSS version 21.0 for Windows. A significance level of 5% was applied to all tests. The Wilcoxon signed-rank and chi-square tests were utilized to compare categorical and quantitative variables across groups. Responses to the questionnaires were recorded on numerical Likert scales ranging from 1 to 5 for OFS and 0 to 4 for OHIP-14. The mean OHIP-14 and OFS scores were compared between the pre-rehabilitation and post-rehabilitation stages.
Results:
A comparison between the pre-rehabilitation and post-rehabilitation scores from the OHIP-14 questionnaire revealed a significant difference (p= 0.001). The OFS results indicated significant improvements across all domains following the use of obturators.
Conclusion
Interim obturators play a vital role in improving speech, swallowing, and mastication during the recovery period for patients who have undergone bilateral total maxillectomy. Despite the altered anatomy resulting from the resection, patients adapted effectively and exhibited improvements in their social, psychological, and mental health.
6.Intra-articular Steroid alone vs Hydrodilatation with intraarticular Steroid in Frozen Shoulder - A Randomised Control Trial
Swaroop S ; Gupta P ; Patnaik S ; Reddy SS
Malaysian Orthopaedic Journal 2023;17(No.1):34-39
Introduction: Various non-operative treatment modalities
have been advocated for a frozen shoulder. In the present
study we compared the efficacy of single intra-articular
steroid injection vs hydrodilatation with intra-articular
steroids for frozen shoulder (FS) in the frozen phase.
Materials and methods: This was a prospective,
randomised control trial (RCT) done at a tertiary care centre.
A total of 108 participants were randomised into two groupsone group received intra-articular steroid with
hydrodilatation (HDS) and other group received intraarticular steroid injection only (S). Shoulder Pain and
Disability Index (SPADI) scores were taken, and statistical
analysis was done to measure the outcome at two weeks, six
weeks and three-month intervals after the injection.
Result: There was significant improvement in symptoms at
each interval for both the groups (p=0.0). There was no
statistically significant difference in the SPADI score
between the two groups at two weeks post injection,
however at six weeks (p=0.04) and 3 months (p=0.001)
significant difference in the SPADI score was demonstrated
with better scores in group S. The mean duration of analgesia
required in group HDS was 5.17 days (S.D.=1.73) and for
group S was 4.28 days (S.D.=1.01), with a statistical
significance (p=0.002).
Conclusion: Better clinical results were obtained at six
weeks and three months with the group receiving
corticosteroid only and also had a lesser requirement of
analgesia post-intervention. Thus, intra-articular steroid
injection only seems to be a more desirable method of
management during the frozen phase of FS than that of
hydrodilatation with intra-articular steroid injection.
7.COVID-19 vaccination uptake and adverse events following COVID-19 immunization in pregnant women in Northern India: a prospective, comparative, cohort study
Aravind P. GANDHI ; JS THAKUR ; Madhu GUPTA ; Soundappan KATHIRVEL ; Kapil GOEL ; Tarundeep SINGH
Journal of Rural Medicine 2022;17(4):228-235
Objectives: The most commonly used vaccine in India, Covishield, is a recombinant adenovirus vector vaccine for which safety data in pregnant women are not available. The present study was conducted to assess the uptake of COVID-19 vaccines and monitor adverse events following COVID-19 immunization among pregnant women in northern India.Patients and Methods: A prospective cohort study was conducted among pregnant women registered with the antenatal clinics in Chandigarh Union Territory (U.T.) in northern India. The study included 247 pregnant women and a comparative group of age-matched, non-pregnant women (247) who received the first dose of the COVID-19 vaccine and were followed up by telephone interviews for adverse events following immunization at three time points until 28 days after vaccination. Multivariate regression (logistic and linear) was used for the adjusted analysis, with adverse events following immunization and the duration of adverse events following immunization as the outcomes.Results: The COVID-19 vaccination uptake rate was 66.8% among the pregnant women. The 28-day incidence rate of adverse events following immunization among the pregnant women was 76.5%. The overall 28-day incidence of adverse events following immunization in pregnant women did not differ significantly from that of non-pregnant women (P=0.153).Conclusion: The Covishield vaccine is safe for pregnant women in India. Further follow-up of the cohort for feto-maternal outcomes needs to be conducted with an adequate sample size to confirm the overall safety profile of the vaccine.
8.Optimal Management of Asymptomatic Carotid Stenosis: Counterbalancing the Benefits with the Potential Risks
Kosmas I. PARASKEVAS ; Dimitri P. MIKHAILIDIS ; Hediyeh BARADARAN ; Alun H. DAVIES ; Hans-Henning ECKSTEIN ; Gianluca FAGGIOLI ; Jose Fernandes e FERNANDES ; Ajay GUPTA ; Mateja K. JEZOVNIK ; Stavros K. KAKKOS ; Niki KATSIKI ; M. Eline KOOI ; Gaetano LANZA ; Christos D. LIAPIS ; Ian M. LOFTUS ; Antoine MILLON ; Andrew N. NICOLAIDES ; Pavel POREDOS ; Rodolfo PINI ; Jean-Baptiste RICCO ; Tatjana RUNDEK ; Luca SABA ; Francesco SPINELLI ; Francesco STILO ; Sherif SULTAN ; Clark J. ZEEBREGTS ; Seemant CHATURVEDI
Journal of Stroke 2022;24(1):163-165
9.Correction to “Prevalence and Associated Factors of Hypertension Subtypes Among the Adult Population in Nepal: Evidence from Demographic and Health Survey Data” Osong Public Health Res Perspect 2019;10(6):327–36
Rajat Das GUPTA ; Animesh TALUKDER ; Shams Shabab HAIDER ; Mohammad Rifat HAIDER
Osong Public Health and Research Perspectives 2022;13(1):80-80
10.Comparison of Bone-Patellar Tendon-Bone Graft, Semitendinosus–Gracilis Graft and Semitendinosus–Gracilis with Preserved Tibial Insertion Graft in Anterior Cruciate Ligament Reconstruction in Sports Persons
Soni A ; Gupta RK ; Raghav M ; Masih GD ; Bansal P
Malaysian Orthopaedic Journal 2021;15(No.2):12-17
Introduction: Bone-patellar tendon-bone (BPTB) and
semitendinosus–gracilis (STG) are the commonest grafts
used for ACL reconstruction. However even after having
been debated for years, there is no consensus about the ideal
graft. Moreover, the literature is deficient about STG graft
with preserved tibial insertion (STGPI) which preserves the
proprioception. Our aim is to compare the outcome of BPTB,
free STG and STGPI grafts after ACL reconstruction in
professional sports persons. We compared the outcome in
terms of mechanical stability, functional outcome, return to
sports activity and degenerative changes.
Materials and Methods: Professional sports persons aged
between 16-50 years operated for ACL tear using BPTB, free
STG and STGPI grafts with minimum follow-up of two
years were identified from hospital records. Patients with
associated knee injuries were excluded. Patients, divided in
three groups according to graft used, were compared in terms
of mechanical stability (arthrometric examination KT-1000
score), functional outcome (Lysholm Score), return to sports
activity (Tegner score and difference in thigh circumference)
and degenerative changes (KL grading).
Results: BPTB graft group was found to be better than free
STG and STGPI graft groups in terms of KT-1000 score.
There was no statistically significant difference among the
groups in terms of Lysholm score, Tegner score, difference in
thigh circumference and KL grading.
Conclusion: BPTB graft is better than free STG and STGPI
grafts in terms of knee stability. When compared for patient
reported outcome, return to sports activity, osteoarthritic
changes and graft failure there is no significant difference
among the three types of grafts.


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